protein

Showing entry for Pappalysin-1

General Target Information
BXGT Id	BXGT013327
Protein Name	Pappalysin-1
Uniport Id	Q13219
Gene	PAPPA
Gene Id	5069
Domain	Laminin_G_3; Peptidase_M43; Sushi
Pfam	PF05572 PF00084
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0044267	cellular protein metabolic process
Biological Process	GO:0007565	female pregnancy
Biological Process	GO:0032354	response to follicle-stimulating hormone
Biological Process	GO:0051384	response to glucocorticoid
molecular function	GO:0004222	metalloendopeptidase activity
molecular function	GO:0008237	metallopeptidase activity
molecular function	GO:0008270	zinc ion binding
cellular component	GO:0005576	extracellular region
cellular component	GO:0005615	extracellular space

Reactome

Pathway Id	Pathway Name
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-392499	Metabolism of proteins

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0000768	BXGD000007	Congenital Abnormality	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000786	BXGD000010	Spontaneous abortion	Female Urogenital Diseases and Pregnancy Complications
C0002793	BXGD000130	Anaplasia	Pathological Conditions, Signs and Symptoms; Neoplasms
C0002895	BXGD000152	Anemia, Sickle Cell	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0002962	BXGD000160	Angina Pectoris	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0002965	BXGD000162	Angina, Unstable	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850	BXGD000225	Arteriosclerosis	Cardiovascular Diseases
C0003869	BXGD000234	Arthritis, Infectious	Infections; Musculoskeletal Diseases
C0003962	BXGD000244	Ascites	Pathological Conditions, Signs and Symptoms
C0004153	BXGD000260	Atherosclerosis	Cardiovascular Diseases
C0004943	BXGD000297	Behcet Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0005612	BXGD000317	Birth Weight	Pathological Conditions, Signs and Symptoms
C0005890	BXGD000345	Body Height
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007131	BXGD000441	Non-Small Cell Lung Carcinoma	Neoplasms; Respiratory Tract Diseases
C0007222	BXGD000454	Cardiovascular Diseases	Cardiovascular Diseases
C0007787	BXGD000487	Transient Ischemic Attack	Nervous System Diseases; Cardiovascular Diseases
C0007820	BXGD000491	Cerebrovascular Disorders	Nervous System Diseases; Cardiovascular Diseases
C0008031	BXGD000511	Chest Pain	Pathological Conditions, Signs and Symptoms
C0008626	BXGD000559	Congenital chromosomal disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0010054	BXGD000647	Coronary Arteriosclerosis	Cardiovascular Diseases
C0010068	BXGD000648	Coronary heart disease	Cardiovascular Diseases
C0011603	BXGD000734	Dermatitis	Skin and Connective Tissue Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013080	BXGD000797	Down Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013537	BXGD000853	Eclampsia	Female Urogenital Diseases and Pregnancy Complications
C0014175	BXGD000904	Endometriosis	Female Urogenital Diseases and Pregnancy Complications
C0015934	BXGD001026	Fetal Growth Retardation	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0018206	BXGD001186	granulosa cell tumor	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0018790	BXGD001221	Cardiac Arrest	Cardiovascular Diseases
C0018798	BXGD001223	Congenital Heart Defects	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018799	BXGD001224	Heart Diseases	Cardiovascular Diseases
C0018801	BXGD001226	Heart failure	Cardiovascular Diseases
C0018802	BXGD001227	Congestive heart failure	Cardiovascular Diseases
C0019693	BXGD001346	HIV Infections	Infections; Immune System Diseases
C0020492	BXGD001404	Hyperostosis	Musculoskeletal Diseases
C0020507	BXGD001413	Hyperplasia	Pathological Conditions, Signs and Symptoms
C0021361	BXGD001499	Female infertility	Female Urogenital Diseases and Pregnancy Complications
C0021390	BXGD001503	Inflammatory Bowel Diseases	Digestive System Diseases
C0022661	BXGD001572	Kidney Failure, Chronic	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024141	BXGD001740	Lupus Erythematosus, Systemic	Skin and Connective Tissue Diseases; Immune System Diseases
C0025202	BXGD001832	melanoma	Neoplasms
C0027051	BXGD001963	Myocardial Infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0029400	BXGD002134	Osteitis	Musculoskeletal Diseases
C0029925	BXGD002181	Ovarian Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032051	BXGD002326	Placental Insufficiency	Female Urogenital Diseases and Pregnancy Complications
C0032460	BXGD002355	Polycystic Ovary Syndrome	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0037369	BXGD002691	Smoking	Behavior and Behavior Mechanisms
C0038013	BXGD002725	Ankylosing spondylitis	Musculoskeletal Diseases
C0038279	BXGD002744	Sterility, Postpartum	Female Urogenital Diseases and Pregnancy Complications
C0039103	BXGD002791	Synovitis	Musculoskeletal Diseases
C0041408	BXGD002923	Turner Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0042870	BXGD003008	Vitamin D Deficiency	Nutritional and Metabolic Diseases
C0085110	BXGD003126	Severe Combined Immunodeficiency	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0085207	BXGD003140	Gestational Diabetes	Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085652	BXGD003224	Pyoderma Gangrenosum	Skin and Connective Tissue Diseases
C0086666	BXGD003305	Myocardial Preinfarction Syndrome	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151744	BXGD003469	Myocardial Ischemia	Cardiovascular Diseases
C0152095	BXGD003537	Patau syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Cardiovascular Diseases
C0152096	BXGD003538	Complete trisomy 18 syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0155626	BXGD003806	Acute myocardial infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0155877	BXGD003830	Allergic asthma	Respiratory Tract Diseases; Immune System Diseases
C0162836	BXGD003990	Hidradenitis Suppurativa	Infections; Skin and Connective Tissue Diseases
C0220620	BXGD004299	Gastrointestinal Carcinoid Tumor	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0220810	BXGD004346	Congenital defects
C0242339	BXGD005150	Dyslipidemias	Nutritional and Metabolic Diseases
C0242379	BXGD005157	Malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0263445	BXGD005307	Acne fulminans	Skin and Connective Tissue Diseases
C0268318	BXGD005896	Cholestasis of pregnancy	Digestive System Diseases; Female Urogenital Diseases and Pregnancy Complications
C0269102	BXGD006053	Endometrioma	Female Urogenital Diseases and Pregnancy Complications
C0272002	BXGD006292	alpha^0^ Thalassemia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0279702	BXGD006685	Conventional (Clear Cell) Renal Cell Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0333693	BXGD006964	Triploidy syndrome	Pathological Conditions, Signs and Symptoms
C0340288	BXGD007316	Stable angina	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0341858	BXGD007425	Endometriosis of uterus	Female Urogenital Diseases and Pregnancy Complications
C0341869	BXGD007427	Subfertility, Female	Female Urogenital Diseases and Pregnancy Complications
C0343751	BXGD007641	Asymptomatic human immunodeficiency virus infection	Infections; Immune System Diseases
C0376634	BXGD008006	Craniofacial Abnormalities	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0400966	BXGD008266	Non-alcoholic Fatty Liver Disease	Digestive System Diseases
C0410422	BXGD008426	Chronic multifocal osteomyelitis	Infections; Musculoskeletal Diseases
C0424678	BXGD008537	Lean body mass
C0489786	BXGD009018	Height
C0520679	BXGD009101	Sleep Apnea, Obstructive	Respiratory Tract Diseases; Nervous System Diseases
C0523465	BXGD009209	Serum albumin measurement
C0524988	BXGD009253	Schnitzler Syndrome	Immune System Diseases
C0553580	BXGD009399	Ewings sarcoma	Neoplasms
C0577631	BXGD009535	Carotid Atherosclerosis	Nervous System Diseases; Cardiovascular Diseases
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0684249	BXGD009790	Carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0742343	BXGD010061	Acute Chest Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0812413	BXGD010847	Malignant Pleural Mesothelioma	Neoplasms; Respiratory Tract Diseases
C0849748	BXGD010890	caruncle	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0852036	BXGD010934	Pregnancy associated hypertension	Female Urogenital Diseases and Pregnancy Complications; Cardiovascular Diseases
C0853879	BXGD010982	Invasive carcinoma of breast	Neoplasms; Skin and Connective Tissue Diseases
C0917730	BXGD011406	Female sterility	Female Urogenital Diseases and Pregnancy Complications
C0919267	BXGD011426	ovarian neoplasm	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948008	BXGD011499	Ischemic stroke	Nervous System Diseases; Cardiovascular Diseases
C0948089	BXGD011504	Acute Coronary Syndrome	Cardiovascular Diseases
C1140680	BXGD011718	Malignant neoplasm of ovary	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955	BXGD012005	Tumor Cell Invasion
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1306460	BXGD012362	Primary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C1395512	BXGD012989	Placental dysfunction
C1519383	BXGD013237	Smoking Behaviors	Behavior and Behavior Mechanisms
C1519689	BXGD013245	Tumor Promotion	Pathological Conditions, Signs and Symptoms; Neoplasms
C1536220	BXGD013341	ST segment elevation myocardial infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1561643	BXGD013363	Chronic Kidney Diseases	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1658953	BXGD013486	tumor vasculature
C1692886	BXGD013495	Arthritis, Bacterial	Infections; Musculoskeletal Diseases
C1858361	BXGD015784	Pyogenic Arthritis, Pyoderma Gangrenosum and Acne	Infections; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C1956346	BXGD016627	Coronary Artery Disease	Cardiovascular Diseases
C2316810	BXGD017030	Chronic kidney disease stage 5	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2711227	BXGD017478	Steatohepatitis	Digestive System Diseases
C3267073	BXGD018613	Autoinflammatory disease
C3890737	BXGD020025	Autoinflammatory Syndrome	Pathological Conditions, Signs and Symptoms
C3891815	BXGD020034	Arthritis, Suppurative	Infections; Musculoskeletal Diseases
C4317091	BXGD022722	Trisomy 18 Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4521042	BXGD023055	Complete Trisomy 21 Syndrome	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4703473	BXGD023650	Atherosclerotic lesion	Cardiovascular Diseases
C4721610	BXGD023760	Carcinoma, Ovarian Epithelial	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0002953	2-Phenethyl isothiocyanate		163.24

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}