Showing entry for cGMP-inhibited 3',5'-cyclic phosphodiesterase B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013345
Protein NamecGMP-inhibited 3',5'-cyclic phosphodiesterase B
Uniport IdQ13370
GenePDE3B
Gene Id5140
DomainPDEase_I
Pfam PF00233  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04371 Apelin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04914 Progesterone-mediated oocyte maturation
5. Organismal Systems 5.2 Endocrine system hsa04922 Glucagon signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04923 Regulation of lipolysis in adipocytes
5. Organismal Systems 5.2 Endocrine system hsa04924 Renin secretion
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001525 angiogenesis
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0016525 negative regulation of angiogenesis
Biological Process GO:0043951 negative regulation of cAMP-mediated signaling
Biological Process GO:0007162 negative regulation of cell adhesion
Biological Process GO:0033629 negative regulation of cell adhesion mediated by integrin
Biological Process GO:0050995 negative regulation of lipid catabolic process
molecular function GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
molecular function GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
molecular function GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0043422 protein kinase B binding
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005794 Golgi apparatus
cellular component GO:0032045 guanyl-nucleotide exchange factor complex
cellular component GO:0016021 integral component of membrane
cellular component GO:0016020 membrane
Reactome
Pathway Id Pathway Name
R-HSA-109703 PKB-mediated events
R-HSA-109703 PKB-mediated events
R-HSA-109704 PI3K Cascade
R-HSA-109704 PI3K Cascade
R-HSA-112399 IRS-mediated signalling
R-HSA-112399 IRS-mediated signalling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-165160 PDE3B signalling
R-HSA-165160 PDE3B signalling
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-2428924 IGF1R signaling cascade
R-HSA-2428924 IGF1R signaling cascade
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418555 G alpha (s) signalling events
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-74752 Signaling by Insulin receptor
R-HSA-74752 Signaling by Insulin receptor
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9607240 FLT3 Signaling
R-HSA-9607240 FLT3 Signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005890 BXGD000345 Body Height
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011859 BXGD000754 Lipoatrophic Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020550 BXGD001429 Hyperthyroidism Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028945 BXGD002099 oligodendroglioma Neoplasms
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0152171 BXGD003552 Idiopathic pulmonary hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0202236 BXGD004086 Triglycerides measurement
C0221032 BXGD004374 Familial generalized lipodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0334634 BXGD007144 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0409959 BXGD008400 Osteoarthritis, Knee Musculoskeletal Diseases
C0523979 BXGD009227 Vitamin D3 measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0751396 BXGD010425 Well Differentiated Oligodendroglioma Neoplasms
C0871470 BXGD011316 Systolic Pressure
C0919758 BXGD011440 Vitamin D measurement
C1136382 BXGD011717 Sclerocystic Ovaries Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1836694 BXGD014150 Striatal Degeneration, Autosomal Dominant Pathological Conditions, Signs and Symptoms
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3714619 BXGD019418 Insulin resistance syndrome Nutritional and Metabolic Diseases
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000202 Papaverine 339.39
BXGC0000204 Theophylline 180.16
BXGC0001502 Caffeine 194.19
BXGC0002588 Magnesium 24.31
BXGC0036634 Cgmp 345.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein