Showing entry for Idiopathic pulmonary hypertension


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD003552
Disease NameIdiopathic pulmonary hypertension
Disease CUI IdC0152171
MeSH Codes C08   C14  
Disease Class NameRespiratory Tract Diseases; Cardiovascular Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00238 BXGT003900 Bone morphogenetic protein receptor type-1B 658 reviewed Kinase
O14641 BXGT004078 Segment polarity protein dishevelled homolog DVL-2 1856 reviewed Signaling
O15379 BXGT004159 Histone deacetylase 3 8841 reviewed Epigenetic regulator
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 8856 reviewed Nuclear receptor
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase 8654 reviewed
P00439 BXGT005539 Phenylalanine-4-hydroxylase 5053 reviewed
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P00742 BXGT005636 Coagulation factor X 2159 reviewed Enzyme
P00747 BXGT005639 Plasminogen 5340 reviewed Enzyme
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P01009 BXGT005714 Alpha-1-antitrypsin 5265 reviewed Enzyme modulator
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01042 BXGT005722 Kininogen-1 3827 reviewed Enzyme modulator
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P01920 BXGT005817 HLA class II histocompatibility antigen, DQ beta 1 chain 3119 reviewed Immune response
P02751 BXGT005943 Fibronectin 2335 reviewed Signaling
P04004 BXGT006125 Vitronectin 7448 reviewed
P04183 BXGT006166 Thymidine kinase, cytosolic 7083 reviewed Kinase
P04629 BXGT006239 High affinity nerve growth factor receptor 4914 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05362 BXGT006350 Intercellular adhesion molecule 1 3383 reviewed
P06733 BXGT006490 Alpha-enolase 2023 reviewed Enzyme
P08047 BXGT006720 Transcription factor Sp1 6667 reviewed Nucleic acid binding
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08246 BXGT006756 Neutrophil elastase 1991 reviewed Enzyme
P08603 BXGT006798 Complement factor H 3075 reviewed
P08865 BXGT006832 40S ribosomal protein SA 3921 reviewed Nucleic acid binding
P09038 BXGT006851 Fibroblast growth factor 2 2247 reviewed Signaling
P09429 BXGT006889 High mobility group protein B1 3146 reviewed Nucleic acid binding
P09917 BXGT006941 Arachidonate 5-lipoxygenase 240 reviewed Enzyme
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P12643 BXGT007830 Bone morphogenetic protein 2 650 reviewed Signaling
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P15151 BXGT008089 Poliovirus receptor 5817 reviewed
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16220 BXGT008206 Cyclic AMP-responsive element-binding protein 1 1385 reviewed
P17931 BXGT008356 Galectin-3 3958 reviewed Signaling
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 2321 reviewed Kinase
P21796 BXGT008690 Voltage-dependent anion-selective channel protein 1 7416 reviewed
P21802 BXGT008691 Fibroblast growth factor receptor 2 2263 reviewed Kinase
P22460 BXGT008774 Potassium voltage-gated channel subfamily A member 5 3741 reviewed Ion channel
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P24530 BXGT008975 Endothelin receptor type B 1910 reviewed G-protein coupled receptor
P25116 BXGT009025 Proteinase-activated receptor 1 2149 reviewed G-protein coupled receptor
P25440 BXGT009044 Bromodomain-containing protein 2 6046 reviewed Epigenetic regulator
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P28223 BXGT009239 5-hydroxytryptamine receptor 2A 3356 reviewed G-protein coupled receptor
P28300 BXGT009243 Protein-lysine 6-oxidase 4015 reviewed
P29274 BXGT009327 Adenosine receptor A2a 135 reviewed G-protein coupled receptor
P29275 BXGT009328 Adenosine receptor A2b 136 reviewed G-protein coupled receptor
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P31645 BXGT009558 Sodium-dependent serotonin transporter 6532 reviewed Transporter
P31946 BXGT009588 14-3-3 protein beta/alpha 7529 reviewed Chaperone
P32418 BXGT009635 Sodium/calcium exchanger 1 6546 reviewed Transporter
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P37023 BXGT009953 Serine/threonine-protein kinase receptor R3 94 reviewed Kinase
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P41595 BXGT010267 5-hydroxytryptamine receptor 2B 3357 reviewed G-protein coupled receptor
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P51692 BXGT010885 Signal transducer and activator of transcription 5B 6777 reviewed Nucleic acid binding
P53667 BXGT011008 LIM domain kinase 1 3984 reviewed Kinase
P55085 BXGT011104 Proteinase-activated receptor 2 2150 reviewed G-protein coupled receptor
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P62736 BXGT011452 Actin, aortic smooth muscle 59 reviewed Cellular structure
P69892 BXGT011647 Hemoglobin subunit gamma-2 3048 reviewed
Q07954 BXGT012950 Prolow-density lipoprotein receptor-related protein 1 4035 reviewed
Q08050 BXGT012958 Forkhead box protein M1 2305 reviewed
Q13363 BXGT013344 C-terminal-binding protein 1 1487 reviewed Transcription factor
Q13370 BXGT013345 cGMP-inhibited 3',5'-cyclic phosphodiesterase B 5140 reviewed
Q13485 BXGT013363 Mothers against decapentaplegic homolog 4 4089 reviewed Transcription factor
Q13873 BXGT013398 Bone morphogenetic protein receptor type-2 659 reviewed Kinase
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16790 BXGT013670 Carbonic anhydrase 9 768 reviewed
Q5Y7D3 BXGT015912 HLA class II histocompatibility antigen DQ beta chain 3119 unreviewed
Q76LX8 BXGT016870 A disintegrin and metalloproteinase with thrombospondin motifs 13 11093 reviewed Enzyme
Q8NER1 BXGT018556 Transient receptor potential cation channel subfamily V member 1 7442 reviewed Ion channel
Q92547 BXGT019355 DNA topoisomerase 2-binding protein 1 11073 reviewed
Q96RI1 BXGT019727 Bile acid receptor 9971 reviewed Nuclear receptor
Q99814 BXGT019965 Endothelial PAS domain-containing protein 1 2034 reviewed Transcription factor
Q9BYF1 BXGT020186 Angiotensin-converting enzyme 2 59272 reviewed Enzyme
Q9BYW2 BXGT020192 Histone-lysine N-methyltransferase SETD2 29072 reviewed Epigenetic regulator
Q9GZX6 BXGT020428 Interleukin-22 50616 reviewed
Q9HBA0 BXGT020516 Transient receptor potential cation channel subfamily V member 4 59341 reviewed Ion channel
Q9NPH5 BXGT021159 NADPH oxidase 4 50507 reviewed Enzyme
Q9P2K8 BXGT021302 eIF-2-alpha kinase GCN2 440275 reviewed
Q9Y4D1 BXGT022273 Disheveled-associated activator of morphogenesis 1 23002 reviewed
Q9UK05 BXGT023094 Growth/differentiation factor 2 2658 reviewed Signaling
O15198 BXGT024049 Mothers against decapentaplegic homolog 9 4093 reviewed Transcription factor
O14649 BXGT025486 Potassium channel subfamily K member 3 3777 reviewed Ion channel
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease