Showing entry for Low-density lipoprotein receptor-related protein 8


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013441
Protein NameLow-density lipoprotein receptor-related protein 8
Uniport IdQ14114
GeneLRP8
Gene Id7804
DomainFXa_inhibition; Ldl_recept_a; Ldl_recept_b
Pfam PF00057   PF00058  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0021541 ammon gyrus development
Biological Process GO:0071397 cellular response to cholesterol
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0021987 cerebral cortex development
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0006897 endocytosis
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0050804 modulation of chemical synaptic transmission
Biological Process GO:0032793 positive regulation of CREB transcription factor activity
Biological Process GO:1900006 positive regulation of dendrite development
Biological Process GO:0061003 positive regulation of dendritic spine morphogenesis
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0061098 positive regulation of protein tyrosine kinase activity
Biological Process GO:0006508 proteolysis
Biological Process GO:0038026 reelin-mediated signaling pathway
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0045088 regulation of innate immune response
Biological Process GO:0042493 response to drug
Biological Process GO:0001523 retinoid metabolic process
Biological Process GO:0007165 signal transduction
molecular function GO:0034185 apolipoprotein binding
molecular function GO:0005509 calcium ion binding
molecular function GO:0038024 cargo receptor activity
molecular function GO:0008035 high-density lipoprotein particle binding
molecular function GO:0019894 kinesin binding
molecular function GO:0005041 low-density lipoprotein particle receptor activity
molecular function GO:0038025 reelin receptor activity
molecular function GO:0004888 transmembrane signaling receptor activity
molecular function GO:0030229 very-low-density lipoprotein particle receptor activity
cellular component GO:0030424 axon
cellular component GO:0005901 caveola
cellular component GO:0030425 dendrite
cellular component GO:0005576 extracellular region
cellular component GO:0016021 integral component of membrane
cellular component GO:0016020 membrane
cellular component GO:0005875 microtubule associated complex
cellular component GO:0043025 neuronal cell body
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-2187338 Visual phototransduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418346 Platelet homeostasis
R-HSA-418594 G alpha (i) signalling events
R-HSA-432142 Platelet sensitization by LDL
R-HSA-6806667 Metabolism of fat-soluble vitamins
R-HSA-975634 Retinoid metabolism and transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0085278 BXGD003150 Antiphospholipid Syndrome Immune System Diseases
C0085409 BXGD003168 Polyendocrinopathies, Autoimmune Immune System Diseases; Endocrine System Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0333463 BXGD006954 Senile Plaques Pathological Conditions, Signs and Symptoms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0392885 BXGD008071 High density lipoprotein measurement
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1445957 BXGD013081 Serum total cholesterol measurement
C1611743 BXGD013456 Familial (FPAH)
C1832662 BXGD013867 MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO
C1867743 BXGD016470 Premature coronary artery atherosclerosis Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2936349 BXGD018109 Plaque, Amyloid Pathological Conditions, Signs and Symptoms
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein