Showing entry for Filamin-C


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013460
Protein NameFilamin-C
Uniport IdQ14315
GeneFLNC
Gene Id2318
DomainCH; Filamin
Pfam PF00307   PF00630  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05132 Salmonella infection
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034329 cell junction assembly
Biological Process GO:0048747 muscle fiber development
molecular function GO:0003779 actin binding
molecular function GO:0030506 ankyrin binding
molecular function GO:0008092 cytoskeletal protein binding
molecular function GO:0042802 identical protein binding
cellular component GO:0043034 costamere
cellular component GO:0005737 cytoplasm
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0005925 focal adhesion
cellular component GO:0005886 plasma membrane
cellular component GO:0042383 sarcolemma
cellular component GO:0016528 sarcoplasm
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
R-HSA-1500931 Cell-Cell communication
R-HSA-446353 Cell-extracellular matrix interactions
R-HSA-446728 Cell junction organization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003507 BXGD000203 Aortic Valve Stenosis Cardiovascular Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004030 BXGD000246 Aspergillosis Infections
C0004031 BXGD000247 Aspergillosis, Allergic Bronchopulmonary Infections; Respiratory Tract Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007196 BXGD000453 Restrictive cardiomyopathy Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007760 BXGD000476 Cerebellar Diseases Nervous System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0014457 BXGD000915 Eosinophilia Hemic and Lymphatic Diseases
C0016522 BXGD001067 Foramen Ovale, Patent Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019825 BXGD001349 Hoarseness Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0022283 BXGD001533 Incontinentia Pigmenti Achromians Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023976 BXGD001724 Long QT Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0024232 BXGD001751 Lymphatic Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026267 BXGD001896 Mitral Valve Prolapse Syndrome Cardiovascular Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0026850 BXGD001942 Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027868 BXGD002053 Neuromuscular Diseases Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0032131 BXGD002330 Plasmacytoma Neoplasms; Immune System Diseases
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0042514 BXGD002989 Tachycardia, Ventricular Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085612 BXGD003204 Ventricular arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0149630 BXGD003334 Bicuspid aortic valve Cardiovascular Diseases
C0151636 BXGD003451 Premature ventricular contractions Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0153452 BXGD003647 Malignant neoplasm of gallbladder Digestive System Diseases; Neoplasms
C0221629 BXGD004467 Proximal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0231712 BXGD004519 Waddling gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235782 BXGD004769 Gallbladder Carcinoma Digestive System Diseases; Neoplasms
C0236642 BXGD004815 Pick Disease of the Brain Nervous System Diseases; Mental Disorders
C0239067 BXGD004961 Difficulty walking up stairs Pathological Conditions, Signs and Symptoms
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0264789 BXGD005428 Familial cardiomyopathy Cardiovascular Diseases
C0270960 BXGD006141 Congenital myopathy (disorder) Musculoskeletal Diseases; Nervous System Diseases
C0279565 BXGD006638 Invasive Lobular Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0340427 BXGD007329 Familial dilated cardiomyopathy Cardiovascular Diseases
C0340429 BXGD007330 Familial restrictive cardiomyopathy (disorder) Cardiovascular Diseases
C0348616 BXGD007876 Other restrictive cardiomyopathy Cardiovascular Diseases
C0349788 BXGD007956 Arrhythmogenic Right Ventricular Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0393524 BXGD008080 Cerebellar Ataxia, Late Onset Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0410189 BXGD008413 Muscular Dystrophy, Emery-Dreifuss Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0427055 BXGD008601 Facial Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Stomatognathic Diseases
C0520679 BXGD009101 Sleep Apnea, Obstructive Respiratory Tract Diseases; Nervous System Diseases
C0560346 BXGD009475 Difficulty running Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678230 BXGD009750 Congenital Epicanthus
C0686353 BXGD009833 Muscular Dystrophies, Limb-Girdle Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0751336 BXGD010392 Distal Muscular Dystrophies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0751651 BXGD010539 Mitochondrial Diseases Nutritional and Metabolic Diseases
C0850666 BXGD010901 Infection caused by Helicobacter pylori Infections
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0949658 BXGD011582 Cardiomyopathy, Hypertrophic, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306710 BXGD012372 Facial asymmetry Pathological Conditions, Signs and Symptoms
C1306759 BXGD012374 Eosinophilic disorder Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1527344 BXGD013275 Dysphonia Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1578482 BXGD013427 Valgus deformities of feet Musculoskeletal Diseases
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1834696 BXGD013989 Hyporeflexia of lower limbs
C1836050 BXGD014075 Filaminopathy, autosomal dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1836057 BXGD014076 Muscle fiber splitting
C1836150 BXGD014082 Gait imbalance
C1836450 BXGD014117 Distal lower limb muscle weakness
C1836451 BXGD014118 Distal lower limb amyotrophy
C1838993 BXGD014351 Episodic vomiting Pathological Conditions, Signs and Symptoms
C1839512 BXGD014380 Limited knee flexion
C1850830 BXGD015181 Exercise-induced myalgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1854494 BXGD015409 Slow progression
C1858033 BXGD015762 Asymmetry of the thorax
C1861861 BXGD016083 CARDIOMYOPATHY, FAMILIAL RESTRICTIVE, 1 (disorder) Cardiovascular Diseases
C1862133 BXGD016105 Decreased finger mobility Musculoskeletal Diseases
C1864716 BXGD016245 Intrinsic hand muscle atrophy
C1866010 BXGD016360 Proximal muscle weakness in lower limbs
C1866141 BXGD016379 Foot dorsiflexor weakness
C1869123 BXGD016553 Limb-girdle muscular dystrophy type 2A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C2678065 BXGD017398 Myofibrillar Myopathy Musculoskeletal Diseases; Nervous System Diseases
C3150620 BXGD018314 Distal upper limb muscle weakness
C3279722 BXGD018773 MYOPATHY, DISTAL, 4
C3279725 BXGD018774 Hip flexor weakness
C3714542 BXGD019413 Lymphoma, Diffuse Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4021264 BXGD020604 Abnormal ventricular septum morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4021581 BXGD020683 Distal upper limb amyotrophy
C4021779 BXGD020774 Abnormality of the calf musculature
C4021866 BXGD020823 obsolete Abnormal heart morphology
C4022157 BXGD020885 Muscle fiber cytoplasmatic inclusion bodies
C4022583 BXGD020924 Fatiguable weakness of proximal limb muscles
C4025831 BXGD021817 Abnormal peripheral nervous system morphology
C4310748 BXGD022647 CARDIOMYOPATHY, FAMILIAL RESTRICTIVE, 5
C4310749 BXGD022648 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 26
C4476982 BXGD022898 Two-raphe bicuspid aortic valve Cardiovascular Diseases
C4477022 BXGD022906 Finger flexor weakness
C4525297 BXGD023131 Stage 0 Gallbladder Cancer AJCC v8
C4525300 BXGD023132 Stage IIA Gallbladder Cancer AJCC v8
C4525301 BXGD023133 Stage IIB Gallbladder Cancer AJCC v8
C4525302 BXGD023134 Stage III Gallbladder Cancer AJCC v8
C4525305 BXGD023135 Stage IV Gallbladder Cancer AJCC v8
C4531288 BXGD023214 Abnormal morphology of left ventricular trabeculae
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002591 Potassium 39.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein