Showing entry for Pick Disease of the Brain


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD004815
Disease NamePick Disease of the Brain
Disease CUI IdC0236642
MeSH Codes C10   F03  
Disease Class NameNervous System Diseases; Mental Disorders
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
F7VJQ1 BXGT003310 Alternative prion protein 5621 reviewed
O14578 BXGT004072 Citron Rho-interacting kinase 11113 reviewed Kinase
O15409 BXGT004166 Forkhead box protein P2 93986 reviewed
O43612 BXGT004605 Orexin 3060 reviewed
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O94907 BXGT005340 Dickkopf-related protein 1 22943 reviewed
O95819 BXGT005398 Mitogen-activated protein kinase kinase kinase kinase 4 9448 reviewed Kinase
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02654 BXGT005911 Apolipoprotein C-I 341 reviewed
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P03951 BXGT006117 Coagulation factor XI 2160 reviewed Enzyme
P04156 BXGT006156 Major prion protein 5621 reviewed
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P05090 BXGT006311 Apolipoprotein D 347 reviewed
P05107 BXGT006316 Integrin beta-2 3689 reviewed Receptor
P06276 BXGT006430 Cholinesterase 590 reviewed
P06493 BXGT006445 Cyclin-dependent kinase 1 983 reviewed Kinase
P07737 BXGT006663 Profilin-1 5216 reviewed
P08047 BXGT006720 Transcription factor Sp1 6667 reviewed Nucleic acid binding
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P09651 BXGT006913 Heterogeneous nuclear ribonucleoprotein A1 3178 reviewed
P0CG47 BXGT007467 Polyubiquitin-B 7314 reviewed Nucleic acid binding
P10636 BXGT007596 Microtubule-associated protein tau 4137 reviewed
P12277 BXGT007789 Creatine kinase B-type 1152 reviewed Kinase
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15336 BXGT008109 Cyclic AMP-dependent transcription factor ATF-2 1386 reviewed Transcription factor
P19440 BXGT008481 Glutathione hydrolase 1 proenzyme 2678 reviewed Enzyme
P21397 BXGT008644 Amine oxidase [flavin-containing] A 4128 reviewed
P22626 BXGT008787 Heterogeneous nuclear ribonucleoproteins A2/B1 3181 reviewed
P23246 BXGT008840 Splicing factor, proline- and glutamine-rich 6421 reviewed Nucleic acid binding
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P30041 BXGT009393 Peroxiredoxin-6 9588 reviewed Enzyme
P30542 BXGT009436 Adenosine receptor A1 134 reviewed G-protein coupled receptor
P31645 BXGT009558 Sodium-dependent serotonin transporter 6532 reviewed Transporter
P32119 BXGT009600 Peroxiredoxin-2 7001 reviewed Enzyme
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35858 BXGT009876 Insulin-like growth factor-binding protein complex acid labile subunit 3483 reviewed Receptor
P36222 BXGT009914 Chitinase-3-like protein 1 1116 reviewed
P36544 BXGT009926 Neuronal acetylcholine receptor subunit alpha-7 89832 reviewed
P36955 BXGT009946 Pigment epithelium-derived factor 5176 reviewed Enzyme modulator
P37840 BXGT010015 Alpha-synuclein 6622 reviewed Transporter
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P40199 BXGT010166 Carcinoembryonic antigen-related cell adhesion molecule 6 4680 reviewed
P42263 BXGT010295 Glutamate receptor 3 2892 reviewed Ion channel
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P42575 BXGT010318 Caspase-2 835 reviewed Enzyme
P42658 BXGT010327 Dipeptidyl aminopeptidase-like protein 6 1804 reviewed Enzyme
P42858 BXGT010341 Huntingtin 3064 reviewed
P43681 BXGT010407 Neuronal acetylcholine receptor subunit alpha-4 1137 reviewed Ion channel
P45983 BXGT010494 Mitogen-activated protein kinase 8 5599 reviewed Kinase
P45984 BXGT010495 Mitogen-activated protein kinase 9 5601 reviewed Kinase
P46108 BXGT010509 Adapter molecule crk 1398 reviewed
P47870 BXGT010591 Gamma-aminobutyric acid receptor subunit beta-2 2561 reviewed Ion channel
P48730 BXGT010656 Casein kinase I isoform delta 1453 reviewed Kinase
P49763 BXGT010737 Placenta growth factor 5228 reviewed Signaling
P49768 BXGT010740 Presenilin-1 5663 reviewed Enzyme
P49792 BXGT010743 E3 SUMO-protein ligase RanBP2 5903 reviewed Enzyme modulator
P49810 BXGT010747 Presenilin-2 5664 reviewed Enzyme
P49841 BXGT010750 Glycogen synthase kinase-3 beta 2932 reviewed Kinase
P50135 BXGT010776 Histamine N-methyltransferase 3176 reviewed
P52758 BXGT010951 2-iminobutanoate/2-iminopropanoate deaminase 10247 reviewed
P55072 BXGT011103 Transitional endoplasmic reticulum ATPase 7415 reviewed
P55786 BXGT011125 Puromycin-sensitive aminopeptidase 9520 reviewed Enzyme
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P60953 BXGT011342 Cell division control protein 42 homolog 998 reviewed Enzyme modulator
P62826 BXGT011463 GTP-binding nuclear protein Ran 5901 reviewed Enzyme modulator
P78330 BXGT011833 Phosphoserine phosphatase 5723 reviewed Enzyme
P78344 BXGT011835 Eukaryotic translation initiation factor 4 gamma 2 1982 reviewed Nucleic acid binding
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 1020 reviewed Kinase
Q00653 BXGT012541 Nuclear factor NF-kappa-B p100 subunit 4791 reviewed Transcription factor
Q06787 BXGT012890 Synaptic functional regulator FMR1 2332 reviewed Nucleic acid binding
Q06830 BXGT012894 Peroxiredoxin-1 5052 reviewed Enzyme
Q08170 BXGT012962 Serine/arginine-rich splicing factor 4 6429 reviewed Nucleic acid binding
Q12840 BXGT013269 Kinesin heavy chain isoform 5A 3798 reviewed Cellular structure
Q13148 BXGT013318 TAR DNA-binding protein 43 23435 reviewed
Q13155 BXGT013320 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 7965 reviewed
Q13501 BXGT013365 Sequestosome-1 8878 reviewed
Q13509 BXGT013366 Tubulin beta-3 chain 10381 reviewed Cellular structure
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 5300 reviewed
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1859 reviewed Kinase
Q14203 BXGT013455 Dynactin subunit 1 1639 reviewed Chaperone
Q14315 BXGT013460 Filamin-C 2318 reviewed
Q15233 BXGT013552 Non-POU domain-containing octamer-binding protein 4841 reviewed Nucleic acid binding
Q15303 BXGT013557 Receptor tyrosine-protein kinase erbB-4 2066 reviewed Kinase
Q15366 BXGT013559 Poly(rC)-binding protein 2 5094 reviewed Enzyme
Q16539 BXGT013634 Mitogen-activated protein kinase 14 1432 reviewed Kinase
Q5S007 BXGT015650 Leucine-rich repeat serine/threonine-protein kinase 2 120892 reviewed Kinase
Q96HC4 BXGT019671 PDZ and LIM domain protein 5 10611 reviewed Cellular structure
Q96QK1 BXGT019720 Vacuolar protein sorting-associated protein 35 55737 reviewed Transporter
Q99497 BXGT019926 Protein/nucleic acid deglycase DJ-1 11315 reviewed Enzyme
Q99523 BXGT019929 Sortilin 6272 reviewed Transporter
Q99558 BXGT019934 Mitogen-activated protein kinase kinase kinase 14 9020 reviewed Kinase
Q99574 BXGT019936 Neuroserpin 5274 reviewed Enzyme modulator
Q99700 BXGT019949 Ataxin-2 6311 reviewed Nucleic acid binding
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 10280 reviewed
Q9HCE7 BXGT020532 E3 ubiquitin-protein ligase SMURF1 57154 reviewed Enzyme
Q9NZJ5 BXGT021275 Eukaryotic translation initiation factor 2-alpha kinase 3 9451 reviewed Kinase
Q9UHD2 BXGT021697 Serine/threonine-protein kinase TBK1 29110 reviewed Kinase
Q9UKA9 BXGT021740 Polypyrimidine tract-binding protein 2 58155 reviewed
Q9UM47 BXGT021772 Neurogenic locus notch homolog protein 3 4854 reviewed
Q9Y468 BXGT022270 Lethal(3)malignant brain tumor-like protein 1 26013 reviewed Epigenetic regulator
P09622 BXGT023116 Dihydrolipoyl dehydrogenase, mitochondrial 1738 reviewed Enzyme
O14966 BXGT024179 Ras-related protein Rab-7L1 8934 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease