Showing entry for Prostaglandin E synthase 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013549
Protein NameProstaglandin E synthase 3
Uniport IdQ15185
GenePTGES3
Gene Id10728
DomainCS
Pfam PF04969  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00590 Arachidonic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051085 chaperone cofactor-dependent protein refolding
Biological Process GO:0051131 chaperone-mediated protein complex assembly
Biological Process GO:0019371 cyclooxygenase pathway
Biological Process GO:0042327 positive regulation of phosphorylation
Biological Process GO:0051973 positive regulation of telomerase activity
Biological Process GO:0001516 prostaglandin biosynthetic process
Biological Process GO:0006457 protein folding
Biological Process GO:0050821 protein stabilization
Biological Process GO:1900034 regulation of cellular response to heat
Biological Process GO:0007165 signal transduction
Biological Process GO:1905323 telomerase holoenzyme complex assembly
Biological Process GO:0000723 telomere maintenance
Biological Process GO:0007004 telomere maintenance via telomerase
Biological Process GO:0006805 xenobiotic metabolic process
molecular function GO:0051087 chaperone binding
molecular function GO:0070182 DNA polymerase binding
molecular function GO:0051879 Hsp90 protein binding
molecular function GO:0050220 prostaglandin-E synthase activity
molecular function GO:0003720 telomerase activity
molecular function GO:0051082 unfolded protein binding
cellular component GO:0101031 chaperone complex
cellular component GO:0000781 chromosome, telomeric region
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
cellular component GO:0005697 telomerase holoenzyme complex
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-211859 Biological oxidations
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-HSA-2262752 Cellular responses to stress
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-3371511 HSF1 activation
R-HSA-3371556 Cellular response to heat stress
R-HSA-3371568 Attenuation phase
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-556833 Metabolism of lipids
R-HSA-5663205 Infectious disease
R-HSA-8937144 Aryl hydrocarbon receptor signalling
R-HSA-8939211 ESR-mediated signaling
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-8978868 Fatty acid metabolism
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-9679191 Potential therapeutics for SARS
R-HSA-9679506 SARS-CoV Infections
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003504 BXGD000202 Aortic Valve Insufficiency Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0010418 BXGD000671 Cryptosporidiosis Digestive System Diseases; Infections; Animal Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024198 BXGD001743 Lyme Disease Infections
C0026499 BXGD001905 Monosomy Pathological Conditions, Signs and Symptoms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0149504 BXGD003322 Encephalopathy, Toxic Nervous System Diseases; Chemically-Induced Disorders
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0154659 BXGD003725 Toxic Encephalitis Nervous System Diseases; Chemically-Induced Disorders
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205698 BXGD004109 Undifferentiated carcinoma Neoplasms
C0206161 BXGD004167 Reticulocyte count (procedure)
C0206682 BXGD004237 Follicular thyroid carcinoma Neoplasms
C0235032 BXGD004715 Neurotoxicity Syndromes Nervous System Diseases; Chemically-Induced Disorders
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0268318 BXGD005896 Cholestasis of pregnancy Digestive System Diseases; Female Urogenital Diseases and Pregnancy Complications
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0457334 BXGD008888 Acute monoblastic leukemia Neoplasms
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0920296 BXGD011464 Developmental reading disorder Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3711376 BXGD019383 Isodicentric Chromosome 15 Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002616 Copper 63.55
BXGC0012243 Ukonan D 151.16
BXGC0027544 Gedunin 482.23
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein