Showing entry for Nuclear receptor coactivator 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013598
Protein NameNuclear receptor coactivator 1
Uniport IdQ15788
GeneNCOA1
Gene Id8648
DomainDUF1518; HLH; NCOA_u2; Nuc_rec_co-act; PAS; PAS_11; SRC-1
Pfam PF07469   PF00010   PF08815   PF00989   PF08832  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04919 Thyroid hormone signaling pathway
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05224 Breast cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0015721 bile acid and bile salt transport
Biological Process GO:0032870 cellular response to hormone stimulus
Biological Process GO:1904017 cellular response to Thyroglobulin triiodothyronine
Biological Process GO:0021549 cerebellum development
Biological Process GO:0021987 cerebral cortex development
Biological Process GO:0044849 estrous cycle
Biological Process GO:0021766 hippocampus development
Biological Process GO:0043967 histone H4 acetylation
Biological Process GO:0021854 hypothalamus development
Biological Process GO:0060713 labyrinthine layer morphogenesis
Biological Process GO:0007595 lactation
Biological Process GO:0008584 male gonad development
Biological Process GO:0060179 male mating behavior
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0045925 positive regulation of female receptivity
Biological Process GO:0045666 positive regulation of neuron differentiation
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0000435 positive regulation of transcription from RNA polymerase II promoter by galactose
Biological Process GO:2001038 regulation of cellular response to drug
Biological Process GO:0019216 regulation of lipid metabolic process
Biological Process GO:0002155 regulation of thyroid hormone mediated signaling pathway
Biological Process GO:0032355 response to estradiol
Biological Process GO:0032570 response to progesterone
Biological Process GO:0032526 response to retinoic acid
molecular function GO:0017162 aryl hydrocarbon receptor binding
molecular function GO:0003682 chromatin binding
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0019899 enzyme binding
molecular function GO:0030331 estrogen receptor binding
molecular function GO:0004402 histone acetyltransferase activity
molecular function GO:0035257 nuclear hormone receptor binding
molecular function GO:0016922 nuclear receptor binding
molecular function GO:0030374 nuclear receptor transcription coactivator activity
molecular function GO:0033142 progesterone receptor binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0046983 protein dimerization activity
molecular function GO:0047485 protein N-terminus binding
molecular function GO:0046965 retinoid X receptor binding
molecular function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function GO:0003713 transcription coactivator activity
cellular component GO:0005829 cytosol
cellular component GO:0043005 neuron projection
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1368082 RORA activates gene expression
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-1592230 Mitochondrial biogenesis
R-HSA-159418 Recycling of bile acids and salts
R-HSA-162582 Signal Transduction
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-192105 Synthesis of bile acids and bile salts
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-194068 Bile acid and bile salt metabolism
R-HSA-1989781 PPARA activates gene expression
R-HSA-1989781 PPARA activates gene expression
R-HSA-211859 Biological oxidations
R-HSA-211897 Cytochrome P450 - arranged by substrate type
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-211976 Endogenous sterols
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-2990846 SUMOylation
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-3214847 HATs acetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-392499 Metabolism of proteins
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-400253 Circadian Clock
R-HSA-4839726 Chromatin organization
R-HSA-556833 Metabolism of lipids
R-HSA-556833 Metabolism of lipids
R-HSA-597592 Post-translational protein modification
R-HSA-8939211 ESR-mediated signaling
R-HSA-8957322 Metabolism of steroids
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-9024446 NR1H2 and NR1H3-mediated signaling
R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
R-HSA-9623433 NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0002893 BXGD000150 Refractory anemias Hemic and Lymphatic Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010051 BXGD000646 Coronary Aneurysm Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014173 BXGD000903 Endometrial Hyperplasia Female Urogenital Diseases and Pregnancy Complications
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0017638 BXGD001132 Glioma Neoplasms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024232 BXGD001751 Lymphatic Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0024668 BXGD001795 Mammary Neoplasms, Experimental Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025261 BXGD001843 Memory Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0026277 BXGD001899 Mixed Salivary Gland Tumor Neoplasms
C0026691 BXGD001917 Mucocutaneous Lymph Node Syndrome Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079773 BXGD003100 Lymphoma, T-Cell, Cutaneous Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0156344 BXGD003851 Endometriosis of ovary Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202236 BXGD004086 Triglycerides measurement
C0206643 BXGD004208 Neoplasms, Fibrous Tissue Neoplasms
C0206655 BXGD004218 Alveolar rhabdomyosarcoma Neoplasms
C0206656 BXGD004219 Embryonal Rhabdomyosarcoma Neoplasms
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0279613 BXGD006651 Childhood Alveolar Rhabdomyosarcoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0334070 BXGD006986 Maturation defect
C0334616 BXGD007140 Malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation Neoplasms; Nervous System Diseases
C0344460 BXGD007674 Carcinoma ex pleomorphic adenoma Neoplasms; Stomatognathic Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935 BXGD009674 Tumor Initiation Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677936 BXGD009737 Refractory cancer Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0856169 BXGD011096 Endothelial dysfunction
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1512981 BXGD013196 Mammary Tumorigenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1707444 BXGD013586 Columnar Cell Change of the Breast
C1740827 BXGD013746 CLL progression
C1842937 BXGD014546 AURAL ATRESIA, CONGENITAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C2940786 BXGD018184 Thyroid Hormone Resistance Syndrome Endocrine System Diseases
C3495917 BXGD019012 Advanced breast cancer
C3839747 BXGD019783 Uterine tumor resembling ovarian sex cord tumor Neoplasms
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4049938 BXGD021956 Physical Activity Measurement
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4722330 BXGD023801 Generalized Thyroid Hormone Resistance Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000759 Arabinan 243.22
BXGC0002144 Tetradecanoic acid 228.37
BXGC0005624 Genistein 270.24
BXGC0024985 (-)-Demecolcine 371.17
BXGC0033960 3-Hydroxybenzo[C]Chromen-6-One 212.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein