Showing entry for Receptor-type tyrosine-protein phosphatase O


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013675
Protein NameReceptor-type tyrosine-protein phosphatase O
Uniport IdQ16827
GenePTPRO
Gene Id5800
Domainfn3; Y_phosphatase
Pfam PF00041   PF00102  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007411 axon guidance
Biological Process GO:0000902 cell morphogenesis
Biological Process GO:0072112 glomerular visceral epithelial cell differentiation
Biological Process GO:0032835 glomerulus development
Biological Process GO:0030032 lamellipodium assembly
Biological Process GO:0002548 monocyte chemotaxis
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0010812 negative regulation of cell-substrate adhesion
Biological Process GO:0003105 negative regulation of glomerular filtration
Biological Process GO:0010977 negative regulation of neuron projection development
Biological Process GO:0090260 negative regulation of retinal ganglion cell axon guidance
Biological Process GO:0035335 peptidyl-tyrosine dephosphorylation
Biological Process GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
Biological Process GO:0006470 protein dephosphorylation
Biological Process GO:0003093 regulation of glomerular filtration
Biological Process GO:0036060 slit diaphragm assembly
molecular function GO:0045296 cadherin binding
molecular function GO:0016791 phosphatase activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0004725 protein tyrosine phosphatase activity
molecular function GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
molecular function GO:0017147 Wnt-protein binding
cellular component GO:0016324 apical plasma membrane
cellular component GO:0030424 axon
cellular component GO:0043197 dendritic spine
cellular component GO:0070062 extracellular exosome
cellular component GO:0098982 GABA-ergic synapse
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0030426 growth cone
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0030027 lamellipodium
cellular component GO:0016328 lateral plasma membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-166520 Signaling by NTRKs
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9034015 Signaling by NTRK3 (TRKC)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0013604 BXGD000859 Edema Pathological Conditions, Signs and Symptoms
C0017668 BXGD001143 Focal glomerulosclerosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027697 BXGD002022 Nephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0033687 BXGD002415 Proteinuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085278 BXGD003150 Antiphospholipid Syndrome Immune System Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0239981 BXGD005011 Hypoalbuminemia Hemic and Lymphatic Diseases
C0268731 BXGD006029 Renal glomerular disease Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0302809 BXGD006852 Fulminant hepatitis Digestive System Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0403601 BXGD008298 Transplant glomerulopathy
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1709661 BXGD013630 Primary Focal Segmental Glomerulosclerosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1861403 BXGD016045 Variable expressivity
C1868672 BXGD016519 NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1868683 BXGD016526 B-CELL MALIGNANCY, LOW-GRADE
C1960398 BXGD016658 HER2-positive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C1969372 BXGD016775 Tubulointerstitial fibrosis
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3280100 BXGD018802 NEPHROTIC SYNDROME, TYPE 6
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein