Showing entry for Focal glomerulosclerosis


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD001143
Disease NameFocal glomerulosclerosis
Disease CUI IdC0017668
MeSH Codes C13   C12  
Disease Class NameFemale Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0000119  
Human Phenotype Ontology TermAbnormality of the genitourinary system
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00151 BXGT003885 PDZ and LIM domain protein 1 9124 reviewed Cellular structure
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O14791 BXGT004101 Apolipoprotein L1 8542 reviewed Transporter
O14936 BXGT004114 Peripheral plasma membrane protein CASK 8573 reviewed Kinase
O15123 BXGT004130 Angiopoietin-2 285 reviewed Signaling
O15230 BXGT004138 Laminin subunit alpha-5 3911 reviewed Enzyme modulator
O15550 BXGT004179 Lysine-specific demethylase 6A 7403 reviewed Epigenetic regulator
O43707 BXGT004616 Alpha-actinin-4 81 reviewed
O43826 BXGT004629 Glucose-6-phosphate exchanger SLC37A4 2542 reviewed Transporter
O60462 BXGT004876 Neuropilin-2 8828 reviewed
O60494 BXGT004879 Cubilin 8029 reviewed
O60603 BXGT004887 Toll-like receptor 2 7097 reviewed
O75844 BXGT005156 CAAX prenyl protease 1 homolog 10269 reviewed Enzyme
O95470 BXGT005382 Sphingosine-1-phosphate lyase 1 8879 reviewed
P00450 BXGT005544 Ceruloplasmin 1356 reviewed Enzyme
P00747 BXGT005639 Plasminogen 5340 reviewed Enzyme
P00749 BXGT005641 Urokinase-type plasminogen activator 5328 reviewed Enzyme
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P01011 BXGT005715 Alpha-1-antichymotrypsin 12 reviewed Enzyme modulator
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01189 BXGT005742 Pro-opiomelanocortin 5443 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01909 BXGT005815 HLA class II histocompatibility antigen, DQ alpha 1 chain 3117 reviewed Immune response
P02452 BXGT005878 Collagen alpha-1(I) chain 1277 reviewed
P02462 BXGT005881 Collagen alpha-1(IV) chain 1282 reviewed
P02545 BXGT005889 Prelamin-A/C 4000 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02751 BXGT005943 Fibronectin 2335 reviewed Signaling
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P04054 BXGT006136 Phospholipase A2 5319 reviewed Enzyme
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05556 BXGT006368 Integrin beta-1 3688 reviewed Receptor
P06850 BXGT006511 Corticoliberin 1392 reviewed Signaling
P06858 BXGT006515 Lipoprotein lipase 4023 reviewed Enzyme
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C 5788 reviewed Enzyme
P08603 BXGT006798 Complement factor H 3075 reviewed
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P10276 BXGT007553 Retinoic acid receptor alpha 5914 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P14678 BXGT008038 Small nuclear ribonucleoprotein-associated proteins B and B' 6628 reviewed Nucleic acid binding
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15941 BXGT008176 Mucin-1 4582 reviewed
P16070 BXGT008186 CD44 antigen 960 reviewed
P16109 BXGT008194 P-selectin 6403 reviewed
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P17643 BXGT008323 5,6-dihydroxyindole-2-carboxylic acid oxidase 7306 reviewed Enzyme
P19099 BXGT008456 Cytochrome P450 11B2, mitochondrial 1585 reviewed
P19174 BXGT008467 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 5335 reviewed Enzyme
P19544 BXGT008494 Wilms tumor protein 7490 reviewed Nucleic acid binding
P25942 BXGT009079 Tumor necrosis factor receptor superfamily member 5 958 reviewed
P26447 BXGT009114 Protein S100-A4 6275 reviewed Calcium-binding protein
P27169 BXGT009161 Serum paraoxonase/arylesterase 1 5444 reviewed
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P29400 BXGT009343 Collagen alpha-5(IV) chain 1287 reviewed
P29475 BXGT009353 Nitric oxide synthase, brain 4842 reviewed
P29965 BXGT009388 CD40 ligand 959 reviewed Signaling
P30556 BXGT009441 Type-1 angiotensin II receptor 185 reviewed G-protein coupled receptor
P31639 BXGT009556 Sodium/glucose cotransporter 2 6524 reviewed Transporter
P33681 BXGT009739 T-lymphocyte activation antigen CD80 941 reviewed
P35228 BXGT009800 Nitric oxide synthase, inducible 4843 reviewed
P35579 BXGT009852 Myosin-9 4627 reviewed
P35580 BXGT009853 Myosin-10 4628 reviewed
P35613 BXGT009856 Basigin 682 reviewed
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P41597 BXGT010268 C-C chemokine receptor type 2 729230 reviewed
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P46108 BXGT010509 Adapter molecule crk 1398 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P46937 BXGT010554 Transcriptional coactivator YAP1 10413 reviewed Enzyme modulator
P47736 BXGT010579 Rap1 GTPase-activating protein 1 5909 reviewed Enzyme modulator
P48023 BXGT010604 Tumor necrosis factor ligand superfamily member 6 356 reviewed Signaling
P50052 BXGT010768 Type-2 angiotensin II receptor 186 reviewed G-protein coupled receptor
P50281 BXGT010788 Matrix metalloproteinase-14 4323 reviewed Enzyme
P51795 BXGT010891 H(+)/Cl(-) exchange transporter 5 1184 reviewed Ion channel
P54802 BXGT011081 Alpha-N-acetylglucosaminidase 4669 reviewed
P55085 BXGT011104 Proteinase-activated receptor 2 2150 reviewed G-protein coupled receptor
P55211 BXGT011111 Caspase-9 842 reviewed Enzyme
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P60953 BXGT011342 Cell division control protein 42 homolog 998 reviewed Enzyme modulator
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P61158 BXGT011364 Actin-related protein 3 10096 reviewed Cellular structure
P61769 BXGT011383 Beta-2-microglobulin 567 reviewed Immune response
P62736 BXGT011452 Actin, aortic smooth muscle 59 reviewed Cellular structure
P62987 BXGT011478 Ubiquitin-60S ribosomal protein L40 7311 reviewed Nucleic acid binding
P63000 BXGT011481 Ras-related C3 botulinum toxin substrate 1 5879 reviewed Enzyme modulator
P63104 BXGT011499 14-3-3 protein zeta/delta 7534 reviewed Chaperone
P80188 BXGT011882 Neutrophil gelatinase-associated lipocalin 3934 reviewed Enzyme
P98155 BXGT012226 Very low-density lipoprotein receptor 7436 reviewed
Q01118 BXGT012570 Sodium channel protein type 7 subunit alpha 6332 reviewed Ion channel
Q06418 BXGT012875 Tyrosine-protein kinase receptor TYRO3 7301 reviewed Kinase
Q06710 BXGT012887 Paired box protein Pax-8 7849 reviewed
Q07075 BXGT012917 Glutamyl aminopeptidase 2028 reviewed Enzyme
Q07812 BXGT012940 Apoptosis regulator BAX 581 reviewed Signaling
Q07817 BXGT012941 Bcl-2-like protein 1 598 reviewed Signaling
Q09013 BXGT013023 Myotonin-protein kinase 1760 reviewed Kinase
Q12965 BXGT013285 Unconventional myosin-Ie 4643 reviewed Cellular structure
Q13085 BXGT013309 Acetyl-CoA carboxylase 1 31 reviewed
Q13155 BXGT013320 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 7965 reviewed
Q13418 BXGT013351 Integrin-linked protein kinase 3611 reviewed Kinase
Q13563 BXGT013377 Polycystin-2 5311 reviewed Ion channel
Q13621 BXGT013383 Solute carrier family 12 member 1 6557 reviewed Transporter
Q14108 BXGT013440 Lysosome membrane protein 2 950 reviewed Receptor
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14145 BXGT013448 Kelch-like ECH-associated protein 1 9817 reviewed
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16539 BXGT013634 Mitogen-activated protein kinase 14 1432 reviewed Kinase
Q16566 BXGT013639 Calcium/calmodulin-dependent protein kinase type IV 814 reviewed Kinase
Q16611 BXGT013644 Bcl-2 homologous antagonist/killer 578 reviewed Signaling
Q16827 BXGT013675 Receptor-type tyrosine-protein phosphatase O 5800 reviewed
Q8WXF7 BXGT019011 Atlastin-1 51062 reviewed Enzyme modulator
Q96AX1 BXGT019620 Vacuolar protein sorting-associated protein 33A 65082 reviewed Transporter
Q96D42 BXGT019636 Hepatitis A virus cellular receptor 1 26762 reviewed
Q96D53 BXGT019637 Atypical kinase COQ8B, mitochondrial 79934 reviewed Kinase
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q96I59 BXGT019675 Probable asparagine--tRNA ligase, mitochondrial 79731 reviewed Enzyme
Q96JY6 BXGT019684 PDZ and LIM domain protein 2 64236 reviewed Cellular structure
Q96QV1 BXGT019722 Hedgehog-interacting protein 64399 reviewed
Q99653 BXGT019945 Calcineurin B homologous protein 1 11261 reviewed
Q9GZX6 BXGT020428 Interleukin-22 50616 reviewed
Q9P212 BXGT021297 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 51196 reviewed Enzyme
Q9Y251 BXGT022215 Heparanase 10855 reviewed Enzyme
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
Q01995 BXGT022678 Transgelin 6876 reviewed Cellular structure
P00738 BXGT022874 Haptoglobin 3240 reviewed Enzyme
Q01955 BXGT023255 Collagen alpha-3(IV) chain 1285 reviewed
P21926 BXGT024578 CD9 antigen 928 reviewed
Q92729 BXGT025605 Receptor-type tyrosine-protein phosphatase U 10076 reviewed Enzyme
P11836 BXGT025994 B-lymphocyte antigen CD20 931 reviewed Receptor
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease