Showing entry for Histone-lysine N-methyltransferase SETMAR


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT015014
Protein NameHistone-lysine N-methyltransferase SETMAR
Uniport IdQ53H47
GeneSETMAR
Gene Id6419
DomainHTH_48; Pre-SET; SET; Transposase_1
Pfam PF17906   PF05033   PF00856   PF01359  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00310 Lysine degradation
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0000737 DNA catabolic process, endonucleolytic
Biological Process GO:0000729 DNA double-strand break processing
Biological Process GO:0015074 DNA integration
Biological Process GO:0006303 double-strand break repair via nonhomologous end joining
Biological Process GO:0097676 histone H3-K36 dimethylation
Biological Process GO:0010452 histone H3-K36 methylation
Biological Process GO:0051568 histone H3-K4 methylation
Biological Process GO:0044774 mitotic DNA integrity checkpoint
Biological Process GO:0071157 negative regulation of cell cycle arrest
Biological Process GO:2001251 negative regulation of chromosome organization
Biological Process GO:0090305 nucleic acid phosphodiester bond hydrolysis
Biological Process GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
Biological Process GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining
Biological Process GO:0031297 replication fork processing
molecular function GO:0003677 DNA binding
molecular function GO:0044547 DNA topoisomerase binding
molecular function GO:0003690 double-stranded DNA binding
molecular function GO:0004519 endonuclease activity
molecular function GO:0046975 histone methyltransferase activity (H3-K36 specific)
molecular function GO:0042800 histone methyltransferase activity (H3-K4 specific)
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0003697 single-stranded DNA binding
molecular function GO:0000014 single-stranded DNA endodeoxyribonuclease activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0005730 nucleolus
cellular component GO:0005634 nucleus
cellular component GO:0035861 site of double-strand break
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0005699 BXGD000325 Blast Phase Pathological Conditions, Signs and Symptoms; Neoplasms; Hemic and Lymphatic Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023269 BXGD001627 leiomyosarcoma Neoplasms
C0023440 BXGD001646 Acute Erythroblastic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0242621 BXGD005183 Isochromosomes Pathological Conditions, Signs and Symptoms
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0278134 BXGD006498 Absence of sensation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278607 BXGD006548 Adult Leiomyosarcoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0279986 BXGD006705 Childhood Leiomyosarcoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0334121 BXGD006996 Inflammatory Myofibroblastic Tumor Pathological Conditions, Signs and Symptoms
C0334634 BXGD007144 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0396060 BXGD008181 Congenital laryngeal adductor palsy Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0549297 BXGD009367 Auricular swelling Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0557874 BXGD009444 Global developmental delay
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751691 BXGD010554 Perineurioma Neoplasms; Nervous System Diseases
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1609538 BXGD013444 Latent Tuberculosis Infections
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1719494 BXGD013655 PERIODONTITIS, LOCALIZED AGGRESSIVE Stomatognathic Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3711376 BXGD019383 Isodicentric Chromosome 15 Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C3840085 BXGD019794 Disorder of Achilles tendon
C4529962 BXGD023178 Fatty Liver Disease
C4707793 BXGD023723 Isochromosomy Yp
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein