Showing entry for Inactive serine/threonine-protein kinase VRK3



                       
General Target Information
BXGT IdBXGT018341
Protein NameInactive serine/threonine-protein kinase VRK3
Uniport IdQ8IV63
GeneVRK3
Gene Id51231
DomainPkinase; zinc_ribbon_2
Pfam PF00069   PF13240  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0070373 negative regulation of ERK1 and ERK2 cascade
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0032516 positive regulation of phosphoprotein phosphatase activity
molecular function GO:0005524 ATP binding
molecular function GO:0019903 protein phosphatase binding
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-166520 Signaling by NTRKs
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-198725 Nuclear Events (kinase and transcription factor activation)
R-HSA-198753 ERK/MAPK targets
R-HSA-202670 ERKs are inactivated
R-HSA-448424 Interleukin-17 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases
R-HSA-450294 MAP kinase activation
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-975871 MyD88 cascade initiated on plasma membrane
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0200635 BXGD004041 Lymphocyte Count measurement
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C2986658 BXGD018234 Diffuse Intrinsic Pontine Glioma
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000933 (-)-Arctigenin 372.41
BXGC0001940 Daphnetin 178.14
BXGC0002071 Apigenin 270.24
BXGC0005624 Genistein 270.24
BXGC0005683 Quercetin 302.24
BXGC0007052 Olomoucine 298.34
BXGC0012706 4-hydroxy-5-nitrophenyl acetic acid 197.03
BXGC0013582 Curcumin 368.13
BXGC0020911 Debromohymenialdisine 245.09
BXGC0042870 Piceatannol 244.07
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0051995 Wedelolactone 314.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein