Showing entry for WD repeat-containing protein 48


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018786
Protein NameWD repeat-containing protein 48
Uniport IdQ8TAF3
GeneWDR48
Gene Id57599
DomainDUF3337; WD40
Pfam PF11816   PF00400  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03460 Fanconi anemia pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0042769 DNA damage response, detection of DNA damage
Biological Process GO:0000724 double-strand break repair via homologous recombination
Biological Process GO:0048568 embryonic organ development
Biological Process GO:0048872 homeostasis of number of cells
Biological Process GO:0036297 interstrand cross-link repair
Biological Process GO:0035264 multicellular organism growth
Biological Process GO:0050679 positive regulation of epithelial cell proliferation
Biological Process GO:1903003 positive regulation of protein deubiquitination
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:1902525 regulation of protein monoubiquitination
Biological Process GO:0072520 seminiferous tubule development
Biological Process GO:0007338 single fertilization
Biological Process GO:0048705 skeletal system morphogenesis
Biological Process GO:0043588 skin development
Biological Process GO:0007283 spermatogenesis
Biological Process GO:0016032 viral process
molecular function GO:0043130 ubiquitin binding
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005770 late endosome
cellular component GO:0005764 lysosome
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex
R-HSA-1643685 Disease
R-HSA-392499 Metabolism of proteins
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5688426 Deubiquitination
R-HSA-5689880 Ub-specific processing proteases
R-HSA-597592 Post-translational protein modification
R-HSA-6783310 Fanconi Anemia Pathway
R-HSA-73893 DNA Damage Bypass
R-HSA-73894 DNA Repair
R-HSA-9671555 Signaling by PDGFR in disease
R-HSA-9673766 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007766 BXGD000478 Intracranial Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0008497 BXGD000549 Choriocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0015625 BXGD001006 Fanconi Anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0023269 BXGD001627 leiomyosarcoma Neoplasms
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024314 BXGD001767 Lymphoproliferative Disorders Immune System Diseases; Hemic and Lymphatic Diseases
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0027651 BXGD002009 Neoplasms Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0037579 BXGD002694 Soft Tissue Neoplasms Neoplasms
C0037772 BXGD002703 Spastic Paraplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0206180 BXGD004170 Ki-1+ Anaplastic Large Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0221023 BXGD004369 Cyclic neutropenia Hemic and Lymphatic Diseases
C0231687 BXGD004509 Spastic gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278607 BXGD006548 Adult Leiomyosarcoma Neoplasms
C0278622 BXGD006551 Adult Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0279986 BXGD006705 Childhood Leiomyosarcoma Neoplasms
C0279987 BXGD006706 Childhood Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0334121 BXGD006996 Inflammatory Myofibroblastic Tumor Pathological Conditions, Signs and Symptoms
C0334463 BXGD007076 Malignant Fibrous Histiocytoma Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0730328 BXGD009959 Central Serous Chorioretinopathy Eye Diseases
C0751690 BXGD010553 Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C1275293 BXGD012076 Lymphomatoid papulosis type A (CD-30 positive type) Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332182 BXGD012495 Adult Anaplastic Large Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332942 BXGD012558 Childhood Anaplastic Large Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1739135 BXGD013733 Progression of prostate cancer
C1838391 BXGD014313 Limb hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1849134 BXGD015010 Impaired vibration sensation in the lower limbs
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2749625 BXGD017629 Motor axonal neuropathy
C3160738 BXGD018472 FANCONI ANEMIA, COMPLEMENTATION GROUP D2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3469521 BXGD018910 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0034256 Rottlerin 516.18
BXGC0045812 Trifluoperazine 407.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein