Showing entry for Trifluoperazine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0045812
Compound NameTrifluoperazine
Structure
FormulaC21H24F3N3S
InchiKeyZEWQUBUPAILYHI-UHFFFAOYSA-N
SMILESCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F
InchiInChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3
IUPAC10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine
Molecular Weight407.16
Pubchem Id5566
Chembl IdCHEMBL422
Targets of Information Source
DrugBank DB00831
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 approved; investigational antagonist
Q9NYX4 BXGT021263 Neuron-specific vesicular protein calcyon reviewed - CALY approved; investigational antagonist
P35348 BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A approved; investigational antagonist
P0DP23 BXGT007520 Calmodulin-1 reviewed - CALM1 approved; investigational inhibitor
P63316 BXGT011517 Troponin C, slow skeletal and cardiac muscles reviewed Calcium-binding protein TNNC1 approved; investigational -
P26447 BXGT009114 Protein S100-A4 reviewed Calcium-binding protein S100A4 approved; investigational inhibitor
PDB TFP
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P62157 BXGT011410 Calmodulin reviewed CALM - - - - -
P0DP23 BXGT007520 Calmodulin-1 reviewed CALM1 - - - - -
P63316 BXGT011517 Troponin C, slow skeletal and cardiac muscles reviewed TNNC1 Calcium-binding protein - - - -
P26447 BXGT009114 Protein S100-A4 reviewed S100A4 Calcium-binding protein - - - -
P0DP29 BXGT007523 Calmodulin-1 reviewed Calm1 - - - - -
Binding DB 79181
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT022302 NADPH oxidase 1 reviewed NOX1 - >17000 - -
reviewed BXGT011358 Ubiquitin-conjugating enzyme E2 N reviewed UBE2N - >20000 - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 4400 - - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 44 - - -
reviewed BXGT009534 Histamine H1 receptor reviewed Hrh1 182 - - -
reviewed BXGT019575 D(1A) dopamine receptor reviewed DRD1 740 - - -
reviewed BXGT008560 D(2) dopamine receptor reviewed DRD2 2.1 - - -
reviewed BXGT015986 Sigma non-opioid intracellular receptor 1 reviewed SIGMAR1 345 - - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A >10000 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 14.08 - - -
reviewed BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A 23.8 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 2631.57 - - -
reviewed BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 666.66 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 2.63 - - -
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 62.5 - - -
reviewed BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A 24 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 2600 - - -
reviewed BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 660 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 2.6 - - -
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 62 - - -
reviewed BXGT026170 5-hydroxytryptamine receptor 7 reviewed HTR7 >10000 - - -
reviewed BXGT026170 5-hydroxytryptamine receptor 7 reviewed HTR7 1445.43 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 3.98 - - -
reviewed BXGT006838 5-hydroxytryptamine receptor 2C reviewed Htr2c 100 - - -
reviewed BXGT009532 5-hydroxytryptamine receptor 6 reviewed Htr6 66 - - -
reviewed BXGT009621 5-hydroxytryptamine receptor 7 reviewed Htr7 80 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 0.19 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 1.1 - - -
reviewed BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 32.2 - - -
reviewed BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 170 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 4 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 0.2 - - -
reviewed BXGT009461 D(4) dopamine receptor reviewed Drd4 19 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 135 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 0.96 - - -
reviewed BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 44 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 850 - - -
reviewed BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 197 - - -
reviewed BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 158 - - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 7.4 - - -
reviewed BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 0.45 - - -
reviewed BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C 378 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 0.41 - - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A 950 - - -
reviewed BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A 13 - - -
reviewed BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 118 - - -
reviewed BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 290.8 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 653.7 - - -
reviewed BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B 163.6 - - -
reviewed BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C 391.5 - - -
reviewed BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 1001 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 1.3 - - -
reviewed BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 63 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 - - 532 -
reviewed BXGT011846 DNA-dependent protein kinase catalytic subunit reviewed Kinase PRKDC - 100000 - -
reviewed BXGT009278 Trypanothione reductase reviewed TPR 23000 - - -
reviewed BXGT005957 Serum albumin reviewed Alb - - 1.4 -
reviewed BXGT007520 Calmodulin-1 reviewed CALM1 - - 1000 -
reviewed BXGT024595 Calmodulin-3 reviewed CALM3 - - 1000 -
reviewed BXGT007521 Calmodulin-2 reviewed CALM2 - - 1000 -
reviewed BXGT011410 Calmodulin reviewed CALM - - 3400 -
reviewed BXGT011410 Calmodulin reviewed CALM - - 5000 -
reviewed BXGT009838 Sodium channel protein type 1 subunit alpha reviewed Ion channel SCN1A - 5000 - -
reviewed BXGT008160 Alpha-1B adrenergic receptor reviewed Adra1b - 350 - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a - - 1043 -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 - 16 - -
reviewed BXGT008059 5-hydroxytryptamine receptor 2A reviewed Htr2a 5.2 - - -
reviewed BXGT008160 Alpha-1B adrenergic receptor reviewed Adra1b 29 - - -
reviewed BXGT008472 5-hydroxytryptamine receptor 1A reviewed Htr1a >1000 - - -
reviewed BXGT005616 Lysozyme C-1 reviewed Lyz1 - 9000 - -
reviewed BXGT006500 Beta-glucuronidase reviewed Gusb - 7800 - -
reviewed BXGT008472 5-hydroxytryptamine receptor 1A reviewed Htr1a 411 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 2.2 - - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 6500 - - -
reviewed BXGT013543 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase reviewed Enzyme EBP 8 - - -
reviewed BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed SIGMAR1 15 - - -
reviewed BXGT009627 C-8 sterol isomerase reviewed ERG2 500 - - -
reviewed BXGT009712 Pleiotropic ABC efflux transporter of multiple drugs reviewed PDR5 - 1400 - -
reviewed BXGT009278 Trypanothione reductase reviewed TPR - 72000 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 10900 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 6300 - -
reviewed BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 - 7200 - -
reviewed BXGT020177 Emopamil-binding protein-like reviewed Enzyme EBPL 3.9 - - -
CHEMBL CHEMBL422
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 129 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 '=' 6226 nM
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 31622 nM
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 '=' 12589 nM
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 '=' 10000 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 '=' 1000 nM
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Inhibition '>' 95 %
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 11220 nM
C8Z4T0 BXGT002647 Snq2p unreviewed - EC1118_1D0_2509g INH '=' 6 uM
P28565 BXGT009273 5-hydroxytryptamine receptor 1D reviewed - Htr1d Ki '>' 1000 nM
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki '>' 1000 nM
P30940 BXGT009484 5-hydroxytryptamine receptor 1F reviewed - Htr1f Ki '>' 1000 nM
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki '>' 1000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 6613 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 3719 nM
P40225 BXGT010168 Thrombopoietin reviewed - THPO Potency '=' 15848 nM
P01215 BXGT005743 Glycoprotein hormones alpha chain reviewed - CGA Potency - 14125 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 63095 nM
P33302 BXGT009712 Pleiotropic ABC efflux transporter of multiple drugs reviewed - PDR5 IC50 '=' 1400 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 19952 nM
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 7200 nM
Q8VCH6 BXGT018914 Delta(24)-sterol reductase reviewed - Dhcr24 Inhibition - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 7943 nM
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 23109 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Activity '=' 100 %
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki - - -
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Inhibition '=' 2 %
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 '=' 1995 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P00390 BXGT005526 Glutathione reductase, mitochondrial reviewed Enzyme GSR IC50 - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Activity '=' 91 %
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 199 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 35481 nM
P08482 BXGT006775 Muscarinic acetylcholine receptor M1 reviewed - Chrm1 Potency '=' 10000 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 10000 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 26679 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Potency - 25118 nM
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 58047 nM
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 1995 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 12589 nM
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 1412 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 16481 nM
P61169 BXGT011367 D(2) dopamine receptor reviewed - Drd2 IC50 '=' 16 nM
P61169 BXGT011367 D(2) dopamine receptor reviewed - Drd2 Bmax '=' 207 fM (mg of protein)-1
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 15848 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ki '=' 6500 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 10900 nM
P22310 BXGT008754 UDP-glucuronosyltransferase 1-4 reviewed - UGT1A4 Activity '=' 165 pm/min/mg
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 '=' 15848 nM
Q9Y5S8 BXGT022302 NADPH oxidase 1 reviewed - NOX1 IC50 '>' 17000 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 15848 nM
P32352 BXGT009627 C-8 sterol isomerase reviewed - ERG2 Ki '=' 500 nM
A3EZI9 BXGT001153 Genome polyprotein unreviewed - NS3 IC50 '=' 700 nM
P08908 BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A Activity '=' 76 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
P0DP23 BXGT007520 Calmodulin-1 reviewed - CALM1 Kd '=' 1000 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 25118 nM
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 31622 nM
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Inhibition '=' 73 %
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 1000 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 20596 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 35481 nM
P02769 BXGT005956 Serum albumin reviewed - ALB log K '=' 3 -
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 79432 nM
P22310 BXGT008754 UDP-glucuronosyltransferase 1-4 reviewed - UGT1A4 Activity - - -
P28593 BXGT009278 Trypanothione reductase reviewed - TPR Ki '=' 23000 nM
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 5173 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 '=' 350 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d IC50 '=' 350 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 '=' 350 nM
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
P14842 BXGT008059 5-hydroxytryptamine receptor 2A reviewed - Htr2a Ki '=' 5 nM
P08909 BXGT006838 5-hydroxytryptamine receptor 2C reviewed - Htr2c Ki '=' 5 nM
P30994 BXGT009493 5-hydroxytryptamine receptor 2B reviewed - Htr2b Ki '=' 5 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 630 nM
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 Potency '=' 11220 nM
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 - - -
P02770 BXGT005957 Serum albumin reviewed - Alb Kd '=' 14000 nM
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
P61169 BXGT011367 D(2) dopamine receptor reviewed - Drd2 Ki '=' 2 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 20587 nM
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki - - -
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 18105 nM
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 10000 nM
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki - - -
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 18887 nM
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 - - -
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 16353 nM
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 15848 nM
P06760 BXGT006500 Beta-glucuronidase reviewed - Gusb IC50 '=' 7800 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 - - -
Q15125 BXGT013543 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase reviewed Enzyme EBP Ki '=' 8 nM
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki '=' 15 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 56234 nM
P33302 BXGT009712 Pleiotropic ABC efflux transporter of multiple drugs reviewed - PDR5 INH '=' 8 uM
Q9NY46 BXGT021248 Sodium channel protein type 3 subunit alpha reviewed Ion channel SCN3A Inhibition '=' 79 %
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha reviewed Ion channel SCN2A Inhibition '=' 79 %
P35498 BXGT009838 Sodium channel protein type 1 subunit alpha reviewed Ion channel SCN1A Inhibition '=' 79 %
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki '=' 411 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 50118 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 14689 nM
P02769 BXGT005956 Serum albumin reviewed - ALB logKd '=' 4 -
P09217 BXGT006872 Protein kinase C zeta type reviewed - Prkcz IC50 '=' 30 ug.mL-1
Q9WTQ0 BXGT021929 Protein kinase C theta type reviewed - Prkcq IC50 '=' 30 ug.mL-1
Q64617 BXGT016127 Protein kinase C eta type reviewed - Prkch IC50 '=' 30 ug.mL-1
P09215 BXGT006870 Protein kinase C delta type reviewed - Prkcd IC50 '=' 30 ug.mL-1
P63319 BXGT011518 Protein kinase C gamma type reviewed - Prkcg IC50 '=' 30 ug.mL-1
P09216 BXGT006871 Protein kinase C epsilon type reviewed - Prkce IC50 '=' 30 ug.mL-1
P68403 BXGT011600 Protein kinase C beta type reviewed - Prkcb IC50 '=' 30 ug.mL-1
P05696 BXGT006379 Protein kinase C alpha type reviewed - Prkca IC50 '=' 30 ug.mL-1
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 12589 nM
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase reviewed Kinase AKT1 Inhibition - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Inhibition '>' 95 %
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Inhibition '>' 95 %
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 52673 nM
P14842 BXGT008059 5-hydroxytryptamine receptor 2A reviewed - Htr2a Kd '=' 1 nM
P08909 BXGT006838 5-hydroxytryptamine receptor 2C reviewed - Htr2c Kd '=' 1 nM
P30994 BXGT009493 5-hydroxytryptamine receptor 2B reviewed - Htr2b Kd '=' 1 nM
P14842 BXGT008059 5-hydroxytryptamine receptor 2A reviewed - Htr2a Bmax '=' 53 fM (mg of protein)-1
P08909 BXGT006838 5-hydroxytryptamine receptor 2C reviewed - Htr2c Bmax '=' 53 fM (mg of protein)-1
P30994 BXGT009493 5-hydroxytryptamine receptor 2B reviewed - Htr2b Bmax '=' 53 fM (mg of protein)-1
P35503 BXGT009840 UDP-glucuronosyltransferase 1-3 reviewed - UGT1A3 Activity '=' 0 pm/min/mg
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 '=' 7943 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 - - -
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 18887 nM
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 58047 nM
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Activity '=' 99 %
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Activity '=' 99 %
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 25118 nM
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
Q09GQ4 BXGT013044 ATP binding cassette transporter Abc1p unreviewed - ABC1 Activity - - -
Q9NY46 BXGT021248 Sodium channel protein type 3 subunit alpha reviewed Ion channel SCN3A IC50 '=' 5000 nM
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha reviewed Ion channel SCN2A IC50 '=' 5000 nM
P35498 BXGT009838 Sodium channel protein type 1 subunit alpha reviewed Ion channel SCN1A IC50 '=' 5000 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 891 nM
P00697 BXGT005616 Lysozyme C-1 reviewed - Lyz1 IC50 '=' 9000 nM
P09217 BXGT006872 Protein kinase C zeta type reviewed - Prkcz IC50 '=' 500000 nM
Q9WTQ0 BXGT021929 Protein kinase C theta type reviewed - Prkcq IC50 '=' 500000 nM
Q64617 BXGT016127 Protein kinase C eta type reviewed - Prkch IC50 '=' 500000 nM
P09215 BXGT006870 Protein kinase C delta type reviewed - Prkcd IC50 '=' 500000 nM
P63319 BXGT011518 Protein kinase C gamma type reviewed - Prkcg IC50 '=' 500000 nM
P09216 BXGT006871 Protein kinase C epsilon type reviewed - Prkce IC50 '=' 500000 nM
P68403 BXGT011600 Protein kinase C beta type reviewed - Prkcb IC50 '=' 500000 nM
P05696 BXGT006379 Protein kinase C alpha type reviewed - Prkca IC50 '=' 500000 nM
P28593 BXGT009278 Trypanothione reductase reviewed - TPR IC50 '=' 72000 nM
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Inhibition '>' 95 %
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 44668 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 19952 nM
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 1000 nM
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki '=' 5100 nM
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 20596 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 11220 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 12589 nM
P21918 BXGT008708 D(1B) dopamine receptor reviewed G-protein coupled receptor DRD5 Inhibition '=' 81 %
P61169 BXGT011367 D(2) dopamine receptor reviewed - Drd2 Kd '=' 0 nM
Q9HC16 BXGT020525 DNA dC->dU-editing enzyme APOBEC-3G reviewed Enzyme APOBEC3G Potency - 22387 nM
P43220 BXGT010367 Glucagon-like peptide 1 receptor reviewed G-protein coupled receptor GLP1R Potency - 8912 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 17782 nM
P62157 BXGT011410 Calmodulin reviewed - CALM Kd '=' 5000 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki - - -
Q99549 BXGT019932 M-phase phosphoprotein 8 reviewed Epigenetic regulator MPHOSPH8 Potency - 37685 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 1258 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 29092 nM
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
Q8TAF3 BXGT018786 WD repeat-containing protein 48 reviewed - WDR48 IC50 '=' 8000 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 IC50 '=' 8000 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 35481 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 15848 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 39810 nM
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short reviewed - GNAS Potency - 25118 nM
Q9BY08 BXGT020177 Emopamil-binding protein-like reviewed Enzyme EBPL Ki '=' 3 nM
P78527 BXGT011846 DNA-dependent protein kinase catalytic subunit reviewed Kinase PRKDC IC50 '=' 100000 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 31622 nM
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 15848 nM
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 15848 nM
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP reviewed - HSPA5 Potency - 52119 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 316 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 1995 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 6300 nM
Q8IBS5 BXGT018243 Calcium-dependent protein kinase 4 reviewed - CPK4 Ki '=' 150000 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 19952 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Activity - - -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 56234 nM
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 25118 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 4610 nM
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 16360 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 26608 nM
P43351 BXGT010380 DNA repair protein RAD52 homolog reviewed Nucleic acid binding RAD52 AC50 '=' 13000 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Activity '=' 96 %
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki '=' 29 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Ki '=' 29 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki '=' 29 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '<' 10000 nM
P62157 BXGT011410 Calmodulin reviewed - CALM Kd '=' 3400 nM
P21918 BXGT008708 D(1B) dopamine receptor reviewed G-protein coupled receptor DRD5 Inhibition '>' 95 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00903 Crotalaria assamica Crotalaria assamica Medicinal Plant
BXGF06266 Crotalaria pallida Crotalaria pallida Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease