Showing entry for Calcium-binding mitochondrial carrier protein Aralar2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021727
Protein NameCalcium-binding mitochondrial carrier protein Aralar2
Uniport IdQ9UJS0
GeneSLC25A13
Gene Id10165
DomainMito_carr
Pfam PF00153  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0015810 aspartate transmembrane transport
Biological Process GO:0006754 ATP biosynthetic process
Biological Process GO:0045333 cellular respiration
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0015813 L-glutamate transmembrane transport
Biological Process GO:0043490 malate-aspartate shuttle
Biological Process GO:0006839 mitochondrial transport
Biological Process GO:0051592 response to calcium ion
molecular function GO:0005347 ATP transmembrane transporter activity
molecular function GO:0005509 calcium ion binding
molecular function GO:0042802 identical protein binding
molecular function GO:0015183 L-aspartate transmembrane transporter activity
molecular function GO:0005313 L-glutamate transmembrane transporter activity
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-1268020 Mitochondrial protein import
R-HSA-1430728 Metabolism
R-HSA-70263 Gluconeogenesis
R-HSA-70326 Glucose metabolism
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-71387 Metabolism of carbohydrates
R-HSA-8963693 Aspartate and asparagine metabolism
R-HSA-9609507 Protein localization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001125 BXGD000024 Acidosis, Lactic Nutritional and Metabolic Diseases
C0001807 BXGD000077 Aggressive behavior Behavior and Behavior Mechanisms
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0006114 BXGD000371 Cerebral Edema Nervous System Diseases
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0008372 BXGD000535 Intrahepatic Cholestasis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009421 BXGD000608 Comatose Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009676 BXGD000619 Confusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0011206 BXGD000703 Delirium Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0011253 BXGD000706 Delusions Behavior and Behavior Mechanisms
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013144 BXGD000800 Drowsiness Mental Disorders
C0013528 BXGD000851 Echolalia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014394 BXGD000914 Enuresis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017181 BXGD001103 Gastrointestinal Hemorrhage Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0018524 BXGD001200 Hallucinations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0019151 BXGD001290 Hepatic Encephalopathy Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019214 BXGD001307 Hepatosplenomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Hemic and Lymphatic Diseases
C0020433 BXGD001379 Hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0020639 BXGD001457 Hypoproteinemia Hemic and Lymphatic Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0022354 BXGD001540 Jaundice, Obstructive Pathological Conditions, Signs and Symptoms
C0023380 BXGD001640 Lethargy Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0025521 BXGD001876 Inborn Errors of Metabolism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0027613 BXGD002004 Neonatal hepatitis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Infections
C0027651 BXGD002009 Neoplasms Neoplasms
C0028081 BXGD002070 Night sweats
C0030286 BXGD002201 Pancreatic Diseases Digestive System Diseases
C0030305 BXGD002206 Pancreatitis Digestive System Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0149904 BXGD003383 Cholestatic hepatitis Digestive System Diseases
C0151691 BXGD003460 Decreased HDL cholesterol concentration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0151849 BXGD003486 Alkaline phosphatase raised Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0151872 BXGD003493 Prothrombin time increased Hemic and Lymphatic Diseases
C0162275 BXGD003924 Ketonuria Nutritional and Metabolic Diseases
C0175683 BXGD003998 Citrullinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0220994 BXGD004357 Hyperammonemia Pathological Conditions, Signs and Symptoms
C0231255 BXGD004489 Decreased body mass index Pathological Conditions, Signs and Symptoms
C0232462 BXGD004542 Decrease in appetite Digestive System Diseases; Nervous System Diseases; Mental Disorders
C0232766 BXGD004562 Asterixis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0232939 BXGD004568 Primary physiologic amenorrhea Pathological Conditions, Signs and Symptoms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0235971 BXGD004795 Elevated alpha-fetoprotein
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0239981 BXGD005011 Hypoalbuminemia Hemic and Lymphatic Diseases
C0268307 BXGD005892 Conjugated hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0268312 BXGD005894 Progressive intrahepatic cholestasis (disorder) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0268457 BXGD005952 Aminoacidemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0268483 BXGD005959 Tyrosinemias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268553 BXGD005981 Hyperlysinemias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0270217 BXGD006069 Perinatal jaundice due to inspissated bile syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0338831 BXGD007216 Manic Mental Disorders
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0456070 BXGD008863 Growth delay
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0549399 BXGD009376 Low density lipoprotein increased Nutritional and Metabolic Diseases
C0557874 BXGD009444 Global developmental delay
C0810364 BXGD010846 Cleft Lip with or without Cleft Palate
C0917801 BXGD011412 Sleeplessness Nervous System Diseases; Mental Disorders
C0949173 BXGD011572 Delayed menarche Endocrine System Diseases
C1314665 BXGD012386 Serum alkaline phosphatase raised
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1848701 BXGD014967 Elevated hepatic transaminase
C1848861 BXGD014978 Hyperthreoninemia
C1851959 BXGD015251 Fluctuations in consciousness
C1853942 BXGD015368 CITRULLINEMIA, TYPE II, NEONATAL-ONSET Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1859506 BXGD015904 Acute hyperammonemia Pathological Conditions, Signs and Symptoms
C1863844 BXGD016200 Adult-onset citrullinemia type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1867873 BXGD016473 Failure to thrive in infancy
C1963167 BXGD016686 Memory Impairment, CTCAE 3.0
C1997910 BXGD016864 Citrin deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2673558 BXGD017211 Increased urinary glycerol
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2830004 BXGD017804 Somnolence Pathological Conditions, Signs and Symptoms
C3887612 BXGD019905 Psychomotor Agitation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C4021982 BXGD020856 Abnormal eating behavior
C4023071 BXGD021096 Hypergalactosemia
C4023102 BXGD021107 Elevated plasma citrulline
C4048270 BXGD021897 Decreased antibody level in blood
C4048705 BXGD021907 Hypermethioninemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C4476869 BXGD022882 Elevated gamma-glutamyltransferase activity
C4477095 BXGD022922 Increased lactate dehydrogenase activity
C4551898 BXGD023434 Cholestasis, progressive familial intrahepatic 1 Digestive System Diseases
C4552810 BXGD023525 Irritability, CTCAE
C4553765 BXGD023551 Memory Impairment, CTCAE 5.0
C4688318 BXGD023585 Refractory Colorectal Carcinoma Digestive System Diseases; Neoplasms
C4721769 BXGD023765 Citrullinemia Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0006186 L-Aspartic acid 133.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein