adisease

Showing entry for Sleeplessness

General Disease Information
BXGD Id	BXGD011412
Disease Name	Sleeplessness
Disease CUI Id	C0917801
MeSH Codes	C10 F03
Disease Class Name	Nervous System Diseases; Mental Disorders
Semantic Type	Sign or Symptom
Human Phenotype Ontology Id	HP:0000707
Human Phenotype Ontology Term	Abnormality of the nervous system
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
F7VJQ1	BXGT003310	Alternative prion protein	5621	reviewed
O00255	BXGT003903	Menin	4221	reviewed
O43181	BXGT004576	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	4724	reviewed
O43464	BXGT004595	Serine protease HTRA2, mitochondrial	27429	reviewed
O43612	BXGT004605	Orexin	3060	reviewed
O43614	BXGT004606	Orexin receptor type 2	3062	reviewed	G-protein coupled receptor
O60260	BXGT004864	E3 ubiquitin-protein ligase parkin	5071	reviewed	Enzyme
O75251	BXGT005107	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	374291	reviewed
O75628	BXGT005140	GTP-binding protein REM 1	28954	reviewed
O94760	BXGT005328	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	23576	reviewed	Enzyme
O94811	BXGT005336	Tubulin polymerization-promoting protein	11076	reviewed	Cellular structure
O95363	BXGT005375	Phenylalanine--tRNA ligase, mitochondrial	10667	reviewed	Enzyme
O95865	BXGT005404	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2	23564	reviewed	Enzyme
P00390	BXGT005526	Glutathione reductase, mitochondrial	2936	reviewed	Enzyme
P01011	BXGT005715	Alpha-1-antichymotrypsin	12	reviewed	Enzyme modulator
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01833	BXGT005788	Polymeric immunoglobulin receptor	5284	reviewed
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P04156	BXGT006156	Major prion protein	5621	reviewed
P04181	BXGT006165	Ornithine aminotransferase, mitochondrial	4942	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P07202	BXGT006565	Thyroid peroxidase	7173	reviewed	Enzyme
P08397	BXGT006768	Porphobilinogen deaminase	3145	reviewed	Enzyme
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08684	BXGT006812	Cytochrome P450 3A4	1576	reviewed	Enzyme
P08842	BXGT006830	Steryl-sulfatase	412	reviewed	Enzyme
P08913	BXGT006841	Alpha-2A adrenergic receptor	150	reviewed	G-protein coupled receptor
P09466	BXGT006892	Glycodelin	5047	reviewed	Enzyme
P09936	BXGT006943	Ubiquitin carboxyl-terminal hydrolase isozyme L1	7345	reviewed	Enzyme
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P11712	BXGT007738	Cytochrome P450 2C9	1559	reviewed
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P21333	BXGT008638	Filamin-A	2316	reviewed
P22303	BXGT008751	Acetylcholinesterase	43	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P25325	BXGT009038	3-mercaptopyruvate sulfurtransferase	4357	reviewed	Enzyme
P28223	BXGT009239	5-hydroxytryptamine receptor 2A	3356	reviewed	G-protein coupled receptor
P28472	BXGT009260	Gamma-aminobutyric acid receptor subunit beta-3	2562	reviewed	Ion channel
P29274	BXGT009327	Adenosine receptor A2a	135	reviewed	G-protein coupled receptor
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P35372	BXGT009823	Mu-type opioid receptor	4988	reviewed	G-protein coupled receptor
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P35916	BXGT009881	Vascular endothelial growth factor receptor 3	2324	reviewed	Kinase
P36551	BXGT009927	Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial	1371	reviewed	Enzyme
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P41145	BXGT010225	Kappa-type opioid receptor	4986	reviewed	G-protein coupled receptor
P41252	BXGT010245	Isoleucine--tRNA ligase, cytoplasmic	3376	reviewed	Enzyme
P48039	BXGT010607	Melatonin receptor type 1A	4543	reviewed	G-protein coupled receptor
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P48728	BXGT010654	Aminomethyltransferase, mitochondrial	275	reviewed
P49286	BXGT010691	Melatonin receptor type 1B	4544	reviewed	G-protein coupled receptor
P49683	BXGT010726	Prolactin-releasing peptide receptor	2834	reviewed	G-protein coupled receptor
P49711	BXGT010728	Transcriptional repressor CTCF	10664	reviewed	Transcription factor
P49841	BXGT010750	Glycogen synthase kinase-3 beta	2932	reviewed	Kinase
P53667	BXGT011008	LIM domain kinase 1	3984	reviewed	Kinase
P55211	BXGT011111	Caspase-9	842	reviewed	Enzyme
P63261	BXGT011512	Actin, cytoplasmic 2	71	reviewed	Cellular structure
P78504	BXGT011844	Protein jagged-1	182	reviewed
P80188	BXGT011882	Neutrophil gelatinase-associated lipocalin	3934	reviewed	Enzyme
Q02779	BXGT012670	Mitogen-activated protein kinase kinase kinase 10	4294	reviewed	Kinase
Q06710	BXGT012887	Paired box protein Pax-8	7849	reviewed
Q13509	BXGT013366	Tubulin beta-3 chain	10381	reviewed	Cellular structure
Q14203	BXGT013455	Dynactin subunit 1	1639	reviewed	Chaperone
Q15078	BXGT013534	Cyclin-dependent kinase 5 activator 1	8851	reviewed	Enzyme modulator
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q5S007	BXGT015650	Leucine-rich repeat serine/threonine-protein kinase 2	120892	reviewed	Kinase
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q8IVA8	BXGT018342	Glutamate decarboxylase 1 (Brain, 67kDa)	2571	unreviewed
Q8N159	BXGT018496	N-acetylglutamate synthase, mitochondrial	162417	reviewed
Q8NBP7	BXGT018541	Proprotein convertase subtilisin/kexin type 9	255738	reviewed	Enzyme
Q92854	BXGT019385	Semaphorin-4D	10507	reviewed	Signaling
Q96EN8	BXGT019649	Molybdenum cofactor sulfurase	55034	reviewed
Q99259	BXGT019915	Glutamate decarboxylase 1	2571	reviewed	Enzyme
Q99497	BXGT019926	Protein/nucleic acid deglycase DJ-1	11315	reviewed	Enzyme
Q9BXM7	BXGT020172	Serine/threonine-protein kinase PINK1, mitochondrial	65018	reviewed	Kinase
Q9BY08	BXGT020177	Emopamil-binding protein-like	84650	reviewed	Enzyme
Q9NP58	BXGT021143	ATP-binding cassette sub-family B member 6, mitochondrial	10058	reviewed	Transporter
Q9UJS0	BXGT021727	Calcium-binding mitochondrial carrier protein Aralar2	10165	reviewed	Transporter
Q9UNS1	BXGT022882	Protein timeless homolog	8914	reviewed
P17752	BXGT023118	Tryptophan 5-hydroxylase 1	7166	reviewed
O95399	BXGT024237	Urotensin-2	10911	reviewed
O43613	BXGT025666	Orexin receptor type 1	3061	reviewed	G-protein coupled receptor
P35250	BXGT025854	Replication factor C subunit 2	5982	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}