Showing entry for Potassium voltage-gated channel subfamily D member 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021735
Protein NamePotassium voltage-gated channel subfamily D member 3
Uniport IdQ9UK17
GeneKCND3
Gene Id3752
DomainBTB_2; DUF3399; Ion_trans; Shal-type
Pfam PF02214   PF11879   PF00520   PF11601  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061337 cardiac conduction
Biological Process GO:0086009 membrane repolarization
Biological Process GO:0086013 membrane repolarization during cardiac muscle cell action potential
Biological Process GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential
Biological Process GO:0097623 potassium ion export across plasma membrane
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:0006813 potassium ion transport
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:0086091 regulation of heart rate by cardiac conduction
Biological Process GO:0034765 regulation of ion transmembrane transport
Biological Process GO:0099625 ventricular cardiac muscle cell membrane repolarization
molecular function GO:0005250 A-type (transient outward) potassium channel activity
molecular function GO:0044325 ion channel binding
molecular function GO:0046872 metal ion binding
molecular function GO:0005249 voltage-gated potassium channel activity
cellular component GO:0030425 dendrite
cellular component GO:0043197 dendritic spine
cellular component GO:0098982 GABA-ergic synapse
cellular component GO:0016021 integral component of membrane
cellular component GO:0099060 integral component of postsynaptic specialization membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0042383 sarcolemma
cellular component GO:0008076 voltage-gated potassium channel complex
Reactome
Pathway Id Pathway Name
R-HSA-112316 Neuronal System
R-HSA-1296071 Potassium Channels
R-HSA-1296072 Voltage gated Potassium channels
R-HSA-397014 Muscle contraction
R-HSA-5576891 Cardiac conduction
R-HSA-5576894 Phase 1 - inactivation of fast Na+ channels
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012569 BXGD000777 Diplopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0023976 BXGD001724 Long QT Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0030252 BXGD002199 Palpitations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0030591 BXGD002247 Paroxysmal ventricular tachycardia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0037052 BXGD002662 Sick Sinus Syndrome Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0038644 BXGD002776 Sudden infant death syndrome Pathological Conditions, Signs and Symptoms
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039240 BXGD002804 Supraventricular tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042024 BXGD002949 Urinary Incontinence Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042510 BXGD002987 Ventricular Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085614 BXGD003205 First degree atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085615 BXGD003206 Right bundle branch block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0087012 BXGD003318 Ataxia, Spinocerebellar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0151564 BXGD003440 Cogwheel Rigidity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151723 BXGD003466 Hypomagnesemia Nutritional and Metabolic Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0155707 BXGD003813 Trifascicular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0234378 BXGD004661 Static Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234518 BXGD004683 Slurred speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235480 BXGD004751 Paroxysmal atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0264423 BXGD005389 Asthma, Occupational Respiratory Tract Diseases; Immune System Diseases; Occupational Diseases
C0264893 BXGD005433 Nodal rhythm disorder Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0270850 BXGD006117 Idiopathic generalized epilepsy Nervous System Diseases
C0270853 BXGD006119 Juvenile Myoclonic Epilepsy Nervous System Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0340489 BXGD007336 Lone atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0348626 BXGD007878 Other specified cardiac arrhythmias Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0393519 BXGD008078 Cerebellar Ataxia, Early Onset Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0393525 BXGD008081 Progressive cerebellar ataxia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0427190 BXGD008611 Ataxia, Truncal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0428908 BXGD008641 Sinus Node Dysfunction (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0429021 BXGD008645 P wave duration (observable entity)
C0429087 BXGD008647 Electrocardiogram: P-R interval
C0520806 BXGD009113 Unexplained sudden death Pathological Conditions, Signs and Symptoms
C0520886 BXGD009118 ST segment elevation (finding) Cardiovascular Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0563243 BXGD009479 Poor coordination Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700200 BXGD009879 Presyncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0750937 BXGD010259 Ataxia, Appendicular Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751837 BXGD010604 Gait Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0856863 BXGD011122 Broad-based gait
C1096063 BXGD011600 Drug Resistant Epilepsy Nervous System Diseases
C1142166 BXGD011736 Brugada Syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1305855 BXGD012348 Body mass index
C1399226 BXGD013003 Ectopic rhythm Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1720824 BXGD013686 Sudden Cardiac Arrest Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1837458 BXGD014233 Impaired smooth pursuit
C1843921 BXGD014620 Postural instability Nervous System Diseases
C1846367 BXGD014807 Spinocerebellar ataxia 19 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1853394 BXGD015333 Gaze-evoked horizontal nystagmus Eye Diseases; Nervous System Diseases
C1854372 BXGD015395 Impaired vibration sensation at ankles
C1854494 BXGD015409 Slow progression
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2585653 BXGD017139 Persistent atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2699541 BXGD017461 Cytokine Measurement
C2748542 BXGD017596 CARDIAC CONDUCTION DEFECT, NONSPECIFIC (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C2751898 BXGD017749 Ventricular Fibrillation, Paroxysmal Familial, 1 Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2931783 BXGD018061 Amelogenesis imperfecta nephrocalcinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Stomatognathic Diseases
C3150852 BXGD018342 EARLY REPOLARIZATION ASSOCIATED WITH VENTRICULAR FIBRILLATION
C3160712 BXGD018467 Palpitations, CTCAE
C3468561 BXGD018908 familial atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3715208 BXGD019451 AV Block First Degree by ECG Finding Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C4024768 BXGD021413 Intermittent microsaccadic pursuits
C4087347 BXGD022144 Autosomal dominant cerebellar ataxia
C4225340 BXGD022230 BRUGADA SYNDROME 9
C4551804 BXGD023411 Brugada Syndrome 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002043 Acacetin 284.26
BXGC0024988 Nifedipine 346.12
BXGC0042114 Solifenacin 362.2
BXGC0047867 Dalfampridine 94.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein