Showing entry for Plexin-D1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022275
Protein NamePlexin-D1
Uniport IdQ9Y4D7
GenePLXND1
Gene Id23129
DomainPlexin_cytopl; PSI; Sema; TIG; TIG_plexin
Pfam PF08337   PF01437   PF01403   PF01833   PF17960  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001525 angiogenesis
Biological Process GO:0035904 aorta development
Biological Process GO:0001569 branching involved in blood vessel morphogenesis
Biological Process GO:0003279 cardiac septum development
Biological Process GO:0060976 coronary vasculature development
Biological Process GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching
Biological Process GO:0043542 endothelial cell migration
Biological Process GO:0001822 kidney development
Biological Process GO:0007162 negative regulation of cell adhesion
Biological Process GO:0003151 outflow tract morphogenesis
Biological Process GO:0050772 positive regulation of axonogenesis
Biological Process GO:0032092 positive regulation of protein binding
Biological Process GO:0007221 positive regulation of transcription of Notch receptor target
Biological Process GO:0045765 regulation of angiogenesis
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0043087 regulation of GTPase activity
Biological Process GO:0071526 semaphorin-plexin signaling pathway
Biological Process GO:1902287 semaphorin-plexin signaling pathway involved in axon guidance
Biological Process GO:0007416 synapse assembly
molecular function GO:0019904 protein domain specific binding
molecular function GO:0017154 semaphorin receptor activity
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0030027 lamellipodium
cellular component GO:0031258 lamellipodium membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0002116 semaphorin receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-157118 Signaling by NOTCH
R-HSA-162582 Signal Transduction
R-HSA-373755 Semaphorin interactions
R-HSA-416700 Other semaphorin interactions
R-HSA-422475 Axon guidance
R-HSA-9012852 Signaling by NOTCH3
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003886 BXGD000238 Arthrogryposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005741 BXGD000328 Blepharitis Eye Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0005890 BXGD000345 Body Height
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0010038 BXGD000643 Corneal Opacity Eye Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0012236 BXGD000772 DiGeorge Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015469 BXGD000996 Facial paralysis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Stomatognathic Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027962 BXGD002064 Melanocytic nevus Neoplasms
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0041207 BXGD002898 Truncus Arteriosus, Persistent Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205682 BXGD004105 Waist-Hip Ratio
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0221060 BXGD004384 Mobius Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Stomatognathic Diseases
C0221352 BXGD004444 Syndactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0240340 BXGD005031 Microdontia (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0240379 BXGD005033 Open mouth (finding)
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0265594 BXGD005553 Congenital absence of hand Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266009 BXGD005604 Congenital absence of breast Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0271623 BXGD006222 Hypogonadotropic hypogonadism Endocrine System Diseases
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0424448 BXGD008529 Mask-like facies Nervous System Diseases
C0426868 BXGD008591 Absence of hand
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0541794 BXGD009262 Skeletal muscle atrophy
C0562350 BXGD009476 Hip circumference
C0678230 BXGD009750 Congenital Epicanthus
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0853240 BXGD010969 Mobius II syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Stomatognathic Diseases
C1135196 BXGD011694 Heart Failure, Diastolic Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1658953 BXGD013486 tumor vasculature
C1836192 BXGD014092 Aplasia/Hypoplasia involving the metacarpal bones
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1853246 BXGD015323 Eversion of lower lip
C1854301 BXGD015391 Motor delay Mental Disorders
C1858430 BXGD015792 Death in infancy
C1861975 BXGD016095 Cafe au lait spots, multiple Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C2674608 BXGD017250 Feeding difficulties in infancy
C2749463 BXGD017620 Aplasia/Hypoplasia of the radius
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3179508 BXGD018554 Aplasia/Hypoplasia of the thumb Musculoskeletal Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4021655 BXGD020723 Abnormality of the sense of smell
C4021776 BXGD020772 Abnormality of the voice
C4023916 BXGD021275 Aplasia/Hypoplasia of the tongue
C4024202 BXGD021303 Reduced number of teeth
C4024213 BXGD021304 Aplasia of the pectoralis major muscle
C4025662 BXGD021716 Abnormality of the ulna
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002692 Arsenic 77.95
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein