Showing entry for 5-Hydroxy-3,3',4',6,7,8-hexamethoxyflavone


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0001403
Compound Name5-Hydroxy-3,3',4',6,7,8-hexamethoxyflavone
Structure
FormulaC21H22O9
InchiKeyJDVPHCLYMGBZLE-UHFFFAOYSA-N
SMILESCOC1=C(OC)C=C(C=C1)C1=C(OC)C(=O)C2=C(O)C(OC)=C(OC)C(OC)=C2O1
InchiInChI=1S/C21H22O9/c1-24-11-8-7-10(9-12(11)25-2)16-18(26-3)14(22)13-15(23)19(27-4)21(29-6)20(28-5)17(13)30-16/h7-9,23H,1-6H3
IUPAC2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy-4H-chromen-4-one
Molecular Weight418.39
Pubchem Id136417
Chembl IdCHEMBL422237
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50064899
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT008169 Lethal factor reviewed lef - - - >20000
reviewed BXGT007528 Botulinum neurotoxin type A reviewed botA - - - >20000
CHEMBL CHEMBL422237
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 28183 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 28183 nM
P62826 BXGT011463 GTP-binding nuclear protein Ran reviewed Enzyme modulator RAN Potency - 28183 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 20596 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 11577 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 14581 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 35481 nM
Q13148 BXGT013318 TAR DNA-binding protein 43 reviewed - TARDBP Potency - 35481 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 11220 nM
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 IC50 '>' 40000 nM
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B IC50 '>' 40000 nM
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A IC50 '>' 40000 nM
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E IC50 '>' 40000 nM
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C IC50 '>' 40000 nM
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B IC50 '>' 40000 nM
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB IC50 '>' 40000 nM
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 IC50 '>' 40000 nM
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A IC50 '>' 40000 nM
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A IC50 '>' 40000 nM
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 IC50 '>' 40000 nM
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A IC50 '>' 40000 nM
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C IC50 '>' 40000 nM
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 IC50 '>' 40000 nM
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B IC50 '>' 40000 nM
Q9BUF5 BXGT020135 Tubulin beta-6 chain reviewed Cellular structure TUBB6 Inhibition '=' 4 %
Q9BVA1 BXGT020142 Tubulin beta-2B chain reviewed - TUBB2B Inhibition '=' 4 %
Q13885 BXGT013400 Tubulin beta-2A chain reviewed Cellular structure TUBB2A Inhibition '=' 4 %
Q6PEY2 BXGT016465 Tubulin alpha-3E chain reviewed Cellular structure TUBA3E Inhibition '=' 4 %
Q9BQE3 BXGT020109 Tubulin alpha-1C chain reviewed Cellular structure TUBA1C Inhibition '=' 4 %
P68363 BXGT011594 Tubulin alpha-1B chain reviewed Cellular structure TUBA1B Inhibition '=' 4 %
P07437 BXGT006624 Tubulin beta chain reviewed Cellular structure TUBB Inhibition '=' 4 %
Q3ZCM7 BXGT014551 Tubulin beta-8 chain reviewed - TUBB8 Inhibition '=' 4 %
P04350 BXGT006193 Tubulin beta-4A chain reviewed Cellular structure TUBB4A Inhibition '=' 4 %
Q71U36 BXGT016705 Tubulin alpha-1A chain reviewed Cellular structure TUBA1A Inhibition '=' 4 %
Q13509 BXGT013366 Tubulin beta-3 chain reviewed Cellular structure TUBB3 Inhibition '=' 4 %
P68366 BXGT011595 Tubulin alpha-4A chain reviewed Cellular structure TUBA4A Inhibition '=' 4 %
P0DPH7 BXGT007527 Tubulin alpha-3C chain reviewed - TUBA3C Inhibition '=' 4 %
Q9H4B7 BXGT020475 Tubulin beta-1 chain reviewed Cellular structure TUBB1 Inhibition '=' 4 %
P68371 BXGT011597 Tubulin beta-4B chain reviewed Cellular structure TUBB4B Inhibition '=' 4 %
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 28183 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 25118 nM
Q9NR56 BXGT021179 Muscleblind-like protein 1 reviewed Nucleic acid binding MBNL1 Potency - 19952 nM
P30996 BXGT009494 Botulinum neurotoxin type F reviewed - botF EC50 - 20000 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 17782 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 23109 nM
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 35481 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 35481 nM
P43220 BXGT010367 Glucagon-like peptide 1 receptor reviewed G-protein coupled receptor GLP1R Potency - 2818 nM
P15917 BXGT008169 Lethal factor reviewed - lef EC50 - 20000 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency '=' 39810 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 79432 nM
P0DPI1 BXGT007529 Botulinum neurotoxin type A reviewed - botA EC50 - 20000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 25929 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00057 Sweet orange Citrus sinensis Fruits
BXGF00811 Citrus Fruits
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease