acompound

Showing entry for Honokiol

General Compound Information
BXGC Id	BXGC0021836
Compound Name	Honokiol
Structure
Formula	C18H18O2
InchiKey	FVYXIJYOAGAUQK-UHFFFAOYSA-N
SMILES	C=CCc1ccc(c(c1)c1ccc(c(c1)CC=C)O)O
Inchi	InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
IUPAC	2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
Molecular Weight	266.13
Pubchem Id	72303
Chembl Id	CHEMBL16901

Targets of Information Source

DrugBank

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type

PDB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1

Binding DB

50157304

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT012099	Mitochondrial import inner membrane translocase subunit TIM10	reviewed		TIM10	-	48800	-	-
reviewed	BXGT009779	Cannabinoid receptor 2	reviewed	G-protein coupled receptor	CNR2	1763	-	-	-
reviewed	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	-	-	-	76200
reviewed	BXGT009779	Cannabinoid receptor 2	reviewed	G-protein coupled receptor	CNR2	5.6	-	-	-
reviewed	BXGT008662	Cannabinoid receptor 1	reviewed	G-protein coupled receptor	CNR1	6.5	-	-	-
reviewed	BXGT006400	Prostaglandin G/H synthase 1	reviewed		PTGS1	-	1800	-	-
reviewed	BXGT011858	Prostaglandin G/H synthase 2	reviewed		PTGS2	-	2100	-	-
reviewed	BXGT006941	Arachidonate 5-lipoxygenase	reviewed	Enzyme	ALOX5	-	4200	-	-
reviewed	BXGT008515	Retinoic acid receptor RXR-alpha	reviewed	Nuclear receptor	RXRA	-	-	-	11800
reviewed	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	-	-	-	39300
reviewed	BXGT008662	Cannabinoid receptor 1	reviewed	G-protein coupled receptor	CNR1	-	-	-	>10000
reviewed	BXGT009779	Cannabinoid receptor 2	reviewed	G-protein coupled receptor	CNR2	5610	-	-	-
reviewed	BXGT008662	Cannabinoid receptor 1	reviewed	G-protein coupled receptor	CNR1	6460	-	-	-

CHEMBL

CHEMBL16901

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
Q962Y6	BXGT019597	Thioredoxin glutathione reductase	unreviewed	-	TGR	Potency	'='	44668	nM
B4URF0	BXGT002146	Neuraminidase	unreviewed	-	NA	IC50	'='	30100	nM
P21554	BXGT008662	Cannabinoid receptor 1	reviewed	G-protein coupled receptor	CNR1	Efficacy	'='	168	%
P19793	BXGT008515	Retinoic acid receptor RXR-alpha	reviewed	Nuclear receptor	RXRA	Activity	-	-	-
P34972	BXGT009779	Cannabinoid receptor 2	reviewed	G-protein coupled receptor	CNR2	Activity	-	-	-
P34972	BXGT009779	Cannabinoid receptor 2	reviewed	G-protein coupled receptor	CNR2	Ki	'='	5610	nM
P18505	BXGT008409	Gamma-aminobutyric acid receptor subunit beta-1	reviewed	Ion channel	GABRB1	EC50	'='	57000	nM
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	EC50	'='	57000	nM
O75496	BXGT005132	Geminin	reviewed	-	GMNN	Potency	-	29092	nM
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	reviewed	Nuclear receptor	PPARG	Activity	-	-	-
P19793	BXGT008515	Retinoic acid receptor RXR-alpha	reviewed	Nuclear receptor	RXRA	EC50	'='	11800	nM
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	reviewed	-	KMT2A	Potency	'='	11220	nM
O00255	BXGT003903	Menin	reviewed	-	MEN1	Potency	'='	11220	nM
P79208	BXGT011858	Prostaglandin G/H synthase 2	reviewed	-	PTGS2	Inhibition	'='	88	%
P28472	BXGT009260	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	Ion channel	GABRB3	EC50	'='	59600	nM
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	EC50	'='	59600	nM
P03433	BXGT006070	Polymerase acidic protein	reviewed	-	PA	Inhibition	'='	-	-
P09917	BXGT006941	Arachidonate 5-lipoxygenase	reviewed	Enzyme	ALOX5	Inhibition	'='	94	%
P02791	BXGT005965	Ferritin light chain	reviewed	-	FTL	Potency	'='	35481	nM
P28700	BXGT009286	Retinoic acid receptor RXR-alpha	reviewed	-	Rxra	Activity	-	-	-
Q03181	BXGT012701	Peroxisome proliferator-activated receptor delta	reviewed	Nuclear receptor	PPARD	Activity	-	-	-
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	reviewed	-	KMT2A	Potency	'='	14125	nM
O00255	BXGT003903	Menin	reviewed	-	MEN1	Potency	'='	14125	nM
P17405	BXGT008304	Sphingomyelin phosphodiesterase	reviewed	Enzyme	SMPD1	Potency	-	316227	nM
P10253	BXGT007550	Lysosomal alpha-glucosidase	reviewed	Enzyme	GAA	Potency	'='	35481	nM
Q9Y2T6	BXGT022247	G-protein coupled receptor 55	reviewed	G-protein coupled receptor	GPR55	Inhibition	'='	42	%
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	Smax	'='	1034	%
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	Smax	'='	1034	%
P97612	BXGT012211	Fatty-acid amide hydrolase 1	reviewed	-	Faah	Inhibition	-	-	-
P31644	BXGT009557	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	Ion channel	GABRA5	Smax	'='	347	%
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	Smax	'='	347	%
P19793	BXGT008515	Retinoic acid receptor RXR-alpha	reviewed	Nuclear receptor	RXRA	ED50	'='	11	uM
P51450	BXGT010847	Nuclear receptor ROR-gamma	reviewed	-	Rorc	Potency	'='	35481	nM
Q8WZA2	BXGT019025	Rap guanine nucleotide exchange factor 4	reviewed	Enzyme modulator	RAPGEF4	Potency	-	50118	nM
P18505	BXGT008409	Gamma-aminobutyric acid receptor subunit beta-1	reviewed	Ion channel	GABRB1	Smax	'='	260	%
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	Smax	'='	260	%
P02791	BXGT005965	Ferritin light chain	reviewed	-	FTL	Potency	'='	15848	nM
P02791	BXGT005965	Ferritin light chain	reviewed	-	FTL	Potency	'='	14125	nM
Q194T2	BXGT013743	Non-structural protein 1	unreviewed	-	NS1	Potency	'='	15848	nM
Q99700	BXGT019949	Ataxin-2	reviewed	Nucleic acid binding	ATXN2	Potency	-	28183	nM
P28472	BXGT009260	Gamma-aminobutyric acid receptor subunit beta-3	reviewed	Ion channel	GABRB3	Smax	'='	878	%
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	Smax	'='	878	%
Q13133	BXGT013315	Oxysterols receptor LXR-alpha	reviewed	Nuclear receptor	NR1H3	Activity	-	-	-
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	reviewed	Transcription factor	SMAD3	Potency	-	25118	nM
P06746	BXGT006496	DNA polymerase beta	reviewed	Enzyme	POLB	Potency	'='	35481	nM
P34903	BXGT009769	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	Ion channel	GABRA3	Smax	'='	2386	%
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	Smax	'='	2386	%
B4URF0	BXGT002146	Neuraminidase	unreviewed	-	NA	IC50	'='	1390	nM
O42275	BXGT004559	Acetylcholinesterase	reviewed	-	ache	Inhibition	'='	-3	%
P09917	BXGT006941	Arachidonate 5-lipoxygenase	reviewed	Enzyme	ALOX5	IC50	'='	4200	nM
P81908	BXGT011959	Cholinesterase	reviewed	-	BCHE	Inhibition	'='	7	%
P51450	BXGT010847	Nuclear receptor ROR-gamma	reviewed	-	Rorc	Potency	'='	22387	nM
P05979	BXGT006400	Prostaglandin G/H synthase 1	reviewed	-	PTGS1	Inhibition	'='	91	%
P05979	BXGT006400	Prostaglandin G/H synthase 1	reviewed	-	PTGS1	IC50	'='	1800	nM
P79208	BXGT011858	Prostaglandin G/H synthase 2	reviewed	-	PTGS2	IC50	'='	2100	nM
O75496	BXGT005132	Geminin	reviewed	-	GMNN	Potency	-	206	nM
Q77YF9	BXGT016886	Protein Vpr	unreviewed	-	vpr	Potency	-	63095	nM
O75164	BXGT005104	Lysine-specific demethylase 4A	reviewed	-	KDM4A	Potency	-	63095	nM
P31644	BXGT009557	Gamma-aminobutyric acid receptor subunit alpha-5	reviewed	Ion channel	GABRA5	EC50	'='	23400	nM
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	EC50	'='	23400	nM
P47869	BXGT010590	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	Ion channel	GABRA2	EC50	'='	46400	nM
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	EC50	'='	46400	nM
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	reviewed	-	KMT2A	Potency	'='	10000	nM
O00255	BXGT003903	Menin	reviewed	-	MEN1	Potency	'='	10000	nM
P87108	BXGT012099	Mitochondrial import inner membrane translocase subunit TIM10	reviewed	-	TIM10	IC50	'='	48800	nM
P39748	BXGT010134	Flap endonuclease 1	reviewed	Enzyme	FEN1	Potency	-	70794	nM
Q8R431	BXGT018683	Monoglyceride lipase	reviewed	-	Mgll	Inhibition	-	-	-
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	EC50	'='	39300	nM
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	EC50	'='	39300	nM
P10636	BXGT007596	Microtubule-associated protein tau	reviewed	-	MAPT	Potency	'='	17782	nM
Q9NUW8	BXGT021219	Tyrosyl-DNA phosphodiesterase 1	reviewed	Enzyme	TDP1	Potency	-	25929	nM
P34972	BXGT009779	Cannabinoid receptor 2	reviewed	G-protein coupled receptor	CNR2	EC50	-	-	-
P51450	BXGT010847	Nuclear receptor ROR-gamma	reviewed	-	Rorc	Potency	'='	4466	nM
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	reviewed	-	APEX1	Potency	-	15848	nM
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	Activity	'='	376	%
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	Activity	'='	376	%
P34972	BXGT009779	Cannabinoid receptor 2	reviewed	G-protein coupled receptor	CNR2	Inhibition	-	-	-
P43220	BXGT010367	Glucagon-like peptide 1 receptor	reviewed	G-protein coupled receptor	GLP1R	Potency	-	14125	nM
P11021	BXGT007644	Endoplasmic reticulum chaperone BiP	reviewed	-	HSPA5	Potency	-	17782	nM
Q9NUW8	BXGT021219	Tyrosyl-DNA phosphodiesterase 1	reviewed	Enzyme	TDP1	Potency	-	18356	nM
P21554	BXGT008662	Cannabinoid receptor 1	reviewed	G-protein coupled receptor	CNR1	EC50	'>'	10000	nM
P18507	BXGT008411	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	Ion channel	GABRG2	EC50	'='	76200	nM
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	EC50	'='	76200	nM
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	EC50	'='	76200	nM
P37840	BXGT010015	Alpha-synuclein	reviewed	Transporter	SNCA	Potency	-	35481	nM
P34972	BXGT009779	Cannabinoid receptor 2	reviewed	G-protein coupled receptor	CNR2	Efficacy	'='	0	%
Q03431	BXGT012714	Parathyroid hormone/parathyroid hormone-related peptide receptor	reviewed	G-protein coupled receptor	PTH1R	Potency	-	44668	nM
P21554	BXGT008662	Cannabinoid receptor 1	reviewed	G-protein coupled receptor	CNR1	Ki	'='	6	nM
P47869	BXGT010590	Gamma-aminobutyric acid receptor subunit alpha-2	reviewed	Ion channel	GABRA2	Smax	'='	1130	%
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	Smax	'='	1130	%
P34972	BXGT009779	Cannabinoid receptor 2	reviewed	G-protein coupled receptor	CNR2	Ki	'='	5	nM
P34903	BXGT009769	Gamma-aminobutyric acid receptor subunit alpha-3	reviewed	Ion channel	GABRA3	EC50	'='	52400	nM
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	EC50	'='	52400	nM
Q9GZV3	BXGT020427	High affinity choline transporter 1	reviewed	Transporter	SLC5A7	IC50	-	12022	nM
Q8IL88	BXGT018311	HSP40, subfamily A, putative	unreviewed	-	PF3D7_1437900	AbsAC1000_uM	'='	4	uM
Q9Y2T6	BXGT022247	G-protein coupled receptor 55	reviewed	G-protein coupled receptor	GPR55	Kb	-	-	-
P21554	BXGT008662	Cannabinoid receptor 1	reviewed	G-protein coupled receptor	CNR1	Ki	'='	6460	nM
P18507	BXGT008411	Gamma-aminobutyric acid receptor subunit gamma-2	reviewed	Ion channel	GABRG2	Emax	'='	78	%
P47870	BXGT010591	Gamma-aminobutyric acid receptor subunit beta-2	reviewed	Ion channel	GABRB2	Emax	'='	78	%
P14867	BXGT008061	Gamma-aminobutyric acid receptor subunit alpha-1	reviewed	Ion channel	GABRA1	Emax	'='	78	%

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00090	Star anise	Illicium verum	Herbs and Spices
BXGF00397	Colorado pinyon	Pinus edulis	Nuts
BXGF00459	Wax gourd	Benincasa hispida	Gourds
BXGF00863	Pyrus bourgaeana	Pyrus bourgaeana	Human Edible Plant
BXGF01020	Baccharis truncata	Baccharis truncata	Others
BXGF01101	Ononis viscosa	Ononis viscosa	Others
BXGF01192	Cuphea hyssopifolia	Cuphea hyssopifolia	Human Edible Plant
BXGF01237	Magnolia obovata	Magnolia obovata	Medicinal Plant
BXGF01394	Holarrhena floribunda	Holarrhena floribunda	Medicinal Plant
BXGF01565	Farfugium japonicum	Farfugium japonicum	Medicinal Plant
BXGF01600	Sedum sarmentosum	Sedum sarmentosum	Medicinal Plant
BXGF01628	Salvia broussonetii	Salvia broussonetii	Others
BXGF01656	Eria rigida	Eria rigida	Others
BXGF01691	Gynoxys verrucosa	Gynoxys verrucosa	Others
BXGF01843	Triunia erythrocarpa	Triunia erythrocarpa	Others
BXGF01984	Chloranthus fortunei	Chloranthus fortunei	Others
BXGF02007	Sandoricum koetjape	Sandoricum koetjape	Medicinal Plant
BXGF02033	Suaeda maritima	Suaeda maritima	Medicinal Plant
BXGF02058	Pedicularis rex	Pedicularis rex	Others
BXGF02409	Euphorbia palustris	Euphorbia palustris	Medicinal Plant
BXGF02451	Sorbus torminalis	Sorbus torminalis	Medicinal Plant
BXGF02502	Magnolia biloba	Magnolia biloba	Medicinal Plant
BXGF03158	Rheum officinale	Rheum officinale	Medicinal Plant
BXGF03957	Centaurea benedicta	Centaurea benedicta	Medicinal Plant
BXGF03988	Rheum coreanum	Rheum coreanum	Others
BXGF04069	Posidonia oceanica	Posidonia oceanica	Others
BXGF04381	Chuquiraga erinacea	Chuquiraga erinacea	Others
BXGF04539	Rheum palmatum	Rheum palmatum	Medicinal Plant
BXGF05099	Alpinia flabellata	Alpinia flabellata	Medicinal Plant
BXGF05249	Fouquieria diguetii	Fouquieria diguetii	Others
BXGF05264	Magnolia officinalis	Magnolia officinalis	Medicinal Plant
BXGF05365	Aconitum carmichaelii	Aconitum carmichaelii	Medicinal Plant
BXGF05701	Euphorbia pithyusa	Euphorbia pithyusa	Others
BXGF05851	Aconitum japonicum	Aconitum japonicum	Medicinal Plant
BXGF05877	Rheum tanguticum	Rheum tanguticum	Medicinal Plant
BXGF05915	Fritillaria hupehensis	Fritillaria hupehensis	Medicinal Plant
BXGF06026	Magnolia officinalis rehd et wils	Magnolia officinalis rehd et wils	Others
BXGF06054	Angelica japonica	Angelica japonica	Medicinal Plant
BXGF06158	Lathyrus latifolius	Lathyrus latifolius	Medicinal Plant
BXGF06244	Pterocarpus erinaceus	Pterocarpus erinaceus	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}