Showing entry for 5,6,7,8-Tetrahydroxy-2-(4-Hydroxyphenyl)Chromen-4-One


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0028589
Compound Name5,6,7,8-Tetrahydroxy-2-(4-Hydroxyphenyl)Chromen-4-One
Structure
FormulaC15H10O7
InchiKeySPZXXUUDYMHBSG-UHFFFAOYSA-N
SMILESOc1ccc(cc1)c1cc(=O)c2c(o1)c(O)c(c(c2O)O)O
InchiInChI=1S/C15H10O7/c16-7-3-1-6(2-4-7)9-5-8(17)10-11(18)12(19)13(20)14(21)15(10)22-9/h1-5,16,18-21H
IUPAC5,6,7,8-tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one
Molecular Weight302.04
Pubchem Id96506
Chembl IdCHEMBL234338
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 61867
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 - 18751 - -
reviewed BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 - 108803 - -
reviewed BXGT008148 Intestinal-type alkaline phosphatase 1 reviewed Alpi - - - 71900
reviewed BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI - - - 81000
reviewed BXGT007603 Alkaline phosphatase, germ cell type reviewed Enzyme ALPG - - - 59600
reviewed BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL - - - 43400
reviewed BXGT009002 Cyclin-dependent kinase 2 reviewed Kinase CDK2 - >1.50e+5 - -
reviewed BXGT005956 Serum albumin reviewed ALB - >94228 - -
reviewed BXGT005130 PC4 and SFRS1-interacting protein reviewed Signaling PSIP1 - 53655 - -
reviewed BXGT005130 PC4 and SFRS1-interacting protein reviewed Signaling PSIP1 - 340.9 - -
reviewed BXGT013686 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 reviewed Kinase PFKFB3 1290 - - -
reviewed BXGT013686 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 reviewed Kinase PFKFB3 - 2970 - -
CHEMBL CHEMBL234338
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 2238 nM
P23467 BXGT008869 Receptor-type tyrosine-protein phosphatase beta reviewed - PTPRB Kis '=' 18 uM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 10000 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 12589 nM
P07378 BXGT006616 Phosphoglycerate kinase, glycosomal reviewed - Potency - 4466 nM
Q14191 BXGT013452 Werner syndrome ATP-dependent helicase reviewed Enzyme WRN Potency - 7079 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 IC50 '=' 18751 nM
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 6294 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 19952 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 5 %
P24822 BXGT008996 Intestinal-type alkaline phosphatase reviewed - Iap EC50 - 71900 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency '=' 501 nM
Q16875 BXGT013686 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 reviewed Kinase PFKFB3 IC50 '=' 2970 nM
P04406 BXGT006207 Glyceraldehyde-3-phosphate dehydrogenase reviewed Enzyme GAPDH Potency '=' 8191 nM
P14618 BXGT008027 Pyruvate kinase PKM reviewed Kinase PKM Potency '=' 39810 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 12589 nM
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency '=' 17782 nM
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 20575 nM
P00883 BXGT005683 Fructose-bisphosphate aldolase A reviewed - ALDOA Potency '=' 18337 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 4466 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 14125 nM
O95398 BXGT005378 Rap guanine nucleotide exchange factor 3 reviewed Enzyme modulator RAPGEF3 Potency - 6309 nM
P29990 BXGT009390 Genome polyprotein reviewed - IC50 '>' 100000 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 10000 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 1584 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 19952 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
Q9Y468 BXGT022270 Lethal(3)malignant brain tumor-like protein 1 reviewed Epigenetic regulator L3MBTL1 Potency '=' 3162 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 19952 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 39810 nM
P10696 BXGT007603 Alkaline phosphatase, germ cell type reviewed Enzyme ALPG EC50 '=' 59600 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 11220 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 10000 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 10000 nM
Q9UIF8 BXGT021718 Bromodomain adjacent to zinc finger domain protein 2B reviewed - BAZ2B Potency - 44668 nM
P05186 BXGT006338 Alkaline phosphatase, tissue-nonspecific isozyme reviewed Enzyme ALPL EC50 '=' 43400 nM
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 39810 nM
Q4GZG4 BXGT014813 Phosphoglycerate kinase unreviewed - PGKC Potency - 919 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 29092 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 7519 nM
P09923 BXGT006942 Intestinal-type alkaline phosphatase reviewed Enzyme ALPI EC50 '=' 81000 nM
Q9NR56 BXGT021179 Muscleblind-like protein 1 reviewed Nucleic acid binding MBNL1 Potency - 28183 nM
Q962Y6 BXGT019597 Thioredoxin glutathione reductase unreviewed - TGR Potency '=' 3981 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 15848 nM
Q07817 BXGT012941 Bcl-2-like protein 1 reviewed Signaling BCL2L1 IC50 '>' 108803 nM
P04608 BXGT006236 Protein Tat reviewed - tat IC50 - 74865 nM
Q16875 BXGT013686 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 reviewed Kinase PFKFB3 Ki '=' 1290 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 35481 nM
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 70794 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 4466 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 28183 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 5358 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 23109 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 4744 nM
P02769 BXGT005956 Serum albumin reviewed - ALB IC50 '>' 94228 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 4466 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF02131 Glycyrrhiza Glycyrrhiza Medicinal Plant
BXGF03749 Marrubium cylleneum Marrubium cylleneum Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease