Showing entry for Alpha-1B adrenergic receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009822
Protein NameAlpha-1B adrenergic receptor
Uniport IdP35368
GeneADRA1B
Gene Id147
Domain7tm_1
Pfam PF00001  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
5. Organismal Systems 5.4 Digestive system hsa04970 Salivary secretion
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
Biological Process GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0150099 neuron-glial cell signaling
Biological Process GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0045907 positive regulation of vasoconstriction
Biological Process GO:0055117 regulation of cardiac muscle contraction
molecular function GO:0004937 alpha1-adrenergic receptor activity
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0046982 protein heterodimerization activity
cellular component GO:0005901 caveola
cellular component GO:0005737 cytoplasm
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0031965 nuclear membrane
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-375280 Amine ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-390696 Adrenoceptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-500792 GPCR ligand binding
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020649 BXGD001459 Hypotension Cardiovascular Diseases
C0022333 BXGD001534 Jacksonian Seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0149504 BXGD003322 Encephalopathy, Toxic Nervous System Diseases; Chemically-Induced Disorders
C0149958 BXGD003395 Complex partial seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0154659 BXGD003725 Toxic Encephalitis Nervous System Diseases; Chemically-Induced Disorders
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0234533 BXGD004687 Generalized seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234535 BXGD004688 Clonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235032 BXGD004715 Neurotoxicity Syndromes Nervous System Diseases; Chemically-Induced Disorders
C0270824 BXGD006113 Visual seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270844 BXGD006115 Tonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846 BXGD006116 Epileptic drop attack Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0334037 BXGD006980 Intestinal metaplasia
C0422850 BXGD008457 Seizures, Somatosensory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422852 BXGD008458 Seizures, Auditory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422853 BXGD008459 Olfactory seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422854 BXGD008460 Gustatory seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422855 BXGD008461 Vertiginous seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0751056 BXGD010306 Non-epileptic convulsion Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751110 BXGD010318 Single Seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751123 BXGD010326 Atonic Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751494 BXGD010472 Convulsive Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751495 BXGD010473 Seizures, Focal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751496 BXGD010474 Seizures, Sensory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1383860 BXGD012935 Cardiac Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3495874 BXGD019008 Nonepileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4048158 BXGD021890 Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317123 BXGD022727 Myoclonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4505436 BXGD022962 Generalized Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000538 (R)-Norepinephrine 169.18
BXGC0000651 Harmalan 184.24
BXGC0000982 L-Homocysteine 135.19
BXGC0001545 Harmine 212.25
BXGC0003196 Aripiprazole 448.39
BXGC0004119 Synepherine 167.21
BXGC0005683 Quercetin 302.24
BXGC0005871 Dopamine 153.18
BXGC0005874 Racemethionine 149.21
BXGC0006183 L-Cystine 240.3
BXGC0014068 Amphetamine 135.1
BXGC0016891 Nortriptyline 263.17
BXGC0017369 N-Methyllaurotetanine 341.16
BXGC0017443 Phenylephrine 167.09
BXGC0021210 Phenylpropanolamine 151.1
BXGC0021478 Lipoic Acid 206.04
BXGC0021893 Norepinephrine 169.07
BXGC0026468 roemerine 279.13
BXGC0027118 Tamsulosin 408.17
BXGC0028262 N-methylephedrine 179.13
BXGC0030954 roemerine 279.13
BXGC0031384 Epinephrine 183.09
BXGC0035201 Quinidine 324.18
BXGC0038837 Pseudohypericin 520.08
BXGC0038892 (1R,2S)-Phenylpropanolamine 151.1
BXGC0040582 nantenine 339.15
BXGC0041240 Atenolol 266.16
BXGC0042222 Propranolol 259.16
BXGC0042462 Cysteine 121.02
BXGC0043126 Nicardipine 479.21
BXGC0043578 5-Hydroxy-2-(2-Phenylethyl)Chromen-4-One 266.09
BXGC0044017 Verapamil 454.28
BXGC0046755 Yohimbine 354.19
BXGC0048578 Rediocide A 794.39
BXGC0051314 Nuciferine 295.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein