Showing entry for 4-Aminophenol


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0049633
Compound Name4-Aminophenol
Structure
FormulaC6H7NO
InchiKeyPLIKAWJENQZMHA-UHFFFAOYSA-N
SMILESNc1ccc(cc1)O
InchiInChI=1S/C6H7NO/c7-5-1-3-6(8)4-2-5/h1-4,8H,7H2
IUPAC4-azaniumylphenolate
Molecular Weight109.05
Pubchem Id403
Chembl IdCHEMBL1142
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB 4NL
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P00044 BXGT005443 Cytochrome c iso-1 reviewed CYC1 - - - - -
Binding DB 26195
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT005689 Carbonic anhydrase 1 reviewed CA1 159000 - - -
reviewed BXGT005690 Carbonic anhydrase 2 reviewed CA2 752000 - - -
reviewed BXGT006627 Carbonic anhydrase 3 reviewed CA3 9500 - - -
reviewed BXGT008802 Carbonic anhydrase 4 reviewed CA4 743000 - - -
reviewed BXGT009796 Carbonic anhydrase 5A, mitochondrial reviewed CA5A 867000 - - -
reviewed BXGT008844 Carbonic anhydrase 6 reviewed CA6 23500 - - -
reviewed BXGT010364 Carbonic anhydrase 7 reviewed CA7 1359000 - - -
reviewed BXGT013670 Carbonic anhydrase 9 reviewed CA9 517000 - - -
reviewed BXGT004601 Carbonic anhydrase 12 reviewed CA12 479000 - - -
reviewed BXGT020260 Carbonic anhydrase 13 reviewed Ca13 657000 - - -
reviewed BXGT021769 Carbonic anhydrase 14 reviewed CA14 10100 - - -
reviewed BXGT022229 Carbonic anhydrase 5B, mitochondrial reviewed CA5B 649000 - - -
reviewed BXGT019994 Carbonic anhydrase 15 reviewed Ca15 335000 - - -
CHEMBL CHEMBL1142
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki '=' 752000 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 14125 nM
P9WMR3 BXGT012397 Replicative DNA helicase reviewed - dnaB AC50 '>' 380000 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 25118 nM
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 44668 nM
Q9HC16 BXGT020525 DNA dC->dU-editing enzyme APOBEC-3G reviewed Enzyme APOBEC3G Potency - 35481 nM
O43570 BXGT004601 Carbonic anhydrase 12 reviewed - CA12 Ki '=' 479000 nM
Q9D6N1 BXGT020260 Carbonic anhydrase 13 reviewed - Ca13 Ki '=' 657000 nM
P23280 BXGT008844 Carbonic anhydrase 6 reviewed - CA6 Ki '=' 23500 nM
P22748 BXGT008802 Carbonic anhydrase 4 reviewed - CA4 Ki '=' 743000 nM
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Ki '=' 159000 nM
Q16790 BXGT013670 Carbonic anhydrase 9 reviewed - CA9 Ki '=' 517000 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 17782 nM
Q13951 BXGT013407 Core-binding factor subunit beta reviewed - CBFB Potency - 12589 nM
Q01196 BXGT012575 Runt-related transcription factor 1 reviewed Transcription factor RUNX1 Potency - 12589 nM
Q9Y2D0 BXGT022229 Carbonic anhydrase 5B, mitochondrial reviewed - CA5B Ki '=' 649000 nM
P07451 BXGT006627 Carbonic anhydrase 3 reviewed - CA3 Ki '=' 9500 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 17782 nM
P43166 BXGT010364 Carbonic anhydrase 7 reviewed - CA7 Ki '=' 1359000 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 3162 nM
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 31622 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 17782 nM
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 4466 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 28183 nM
Q9ULX7 BXGT021769 Carbonic anhydrase 14 reviewed - CA14 Ki '=' 10100 nM
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 Potency - 35481 nM
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Potency '=' 31622 nM
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 44668 nM
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 50118 nM
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 10000 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 26603 nM
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Potency - 12589 nM
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Activity '=' 0 pm/min/mg
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 35481 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 28183 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 17782 nM
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 31622 nM
P35218 BXGT009796 Carbonic anhydrase 5A, mitochondrial reviewed - CA5A Ki '=' 867000 nM
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Activity '=' 0 pm/min/mg
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 79432 nM
P51449 BXGT010846 Nuclear receptor ROR-gamma reviewed Nuclear receptor RORC Potency - 42163 nM
P9WMR3 BXGT012397 Replicative DNA helicase reviewed - dnaB AC50 '=' 40600 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 8912 nM
P35869 BXGT009877 Aryl hydrocarbon receptor reviewed Transcription factor AHR Potency - 39810 nM
P9WHJ3 BXGT012297 Protein RecA reviewed - recA EC50 '>' 380000 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 7079 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 25118 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 31622 nM
P22310 BXGT008754 UDP-glucuronosyltransferase 1-4 reviewed - UGT1A4 Activity '=' 0 pm/min/mg
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 6309 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 12817 nM
O75795 BXGT005152 UDP-glucuronosyltransferase 2B17 reviewed - UGT2B17 Activity '=' 0 pm/min/mg
P19224 BXGT008468 UDP-glucuronosyltransferase 1-6 reviewed - UGT1A6 Activity '=' 0 pm/min/mg
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 44668 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 33161 nM
Q99N23 BXGT019994 Carbonic anhydrase 15 reviewed - Ca15 Ki '=' 335000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 12197 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 10000 nM
Q9H7Z6 BXGT020493 Histone acetyltransferase KAT8 reviewed - KAT8 IC50 '>' 500000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 7695 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 12589 nM
O00167 BXGT003887 Eyes absent homolog 2 reviewed - EYA2 Potency - 19014 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 89125 nM
Q09472 BXGT013038 Histone acetyltransferase p300 reviewed - EP300 IC50 '>' 500000 nM
Q92831 BXGT019380 Histone acetyltransferase KAT2B reviewed - KAT2B IC50 '>' 500000 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF04920 Aconitum carmichaeli Aconitum carmichaeli Medicinal Plant
BXGF05365 Aconitum carmichaelii Aconitum carmichaelii Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease