Showing entry for Cocaine esterase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT003942
Protein NameCocaine esterase
Uniport IdO00748
GeneCES2
Gene Id8824
DomainCOesterase
Pfam PF00135  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00983 Drug metabolism - other enzymes
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009056 catabolic process
Biological Process GO:0016042 lipid catabolic process
Biological Process GO:0006693 prostaglandin metabolic process
Biological Process GO:0006805 xenobiotic metabolic process
molecular function GO:0052689 carboxylic ester hydrolase activity
molecular function GO:0080030 methyl indole-3-acetate esterase activity
molecular function GO:0047374 methylumbelliferyl-acetate deacetylase activity
molecular function GO:0004771 sterol esterase activity
molecular function GO:0004806 triglyceride lipase activity
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0005615 extracellular space
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-211859 Biological oxidations
R-HSA-211945 Phase I - Functionalization of compounds
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0009171 BXGD000587 Cocaine Abuse Chemically-Induced Disorders; Mental Disorders
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013221 BXGD000804 Drug toxicity Chemically-Induced Disorders
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016053 BXGD001041 Fibromyalgia Musculoskeletal Diseases; Nervous System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023474 BXGD001662 Leukemia, Myeloid, Chronic-Phase Neoplasms; Hemic and Lymphatic Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0041755 BXGD002933 Adverse reaction to drug Chemically-Induced Disorders
C0043119 BXGD003029 Werner Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079745 BXGD003091 Lymphoma, Large-Cell, Follicular Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085612 BXGD003204 Ventricular arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220621 BXGD004300 Childhood Acute Myeloid Leukemia Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0236736 BXGD004825 Cocaine-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0242350 BXGD005154 Erectile dysfunction Male Urogenital Diseases; Mental Disorders
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0279582 BXGD006639 Childhood Burkitt Leukemia Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0279591 BXGD006642 Adult Burkitt Leukemia Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0393819 BXGD008151 Polyradiculoneuropathy, Chronic Inflammatory Demyelinating Immune System Diseases; Nervous System Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0600427 BXGD009706 Cocaine Dependence Chemically-Induced Disorders; Mental Disorders
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0855112 BXGD011074 Diffuse large B-cell lymphoma refractory Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1443924 BXGD013074 Severe diarrhea Pathological Conditions, Signs and Symptoms
C1533217 BXGD013313 Methamphetamine dependence Chemically-Induced Disorders; Mental Disorders
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2745948 BXGD017569 Hyalinosis, Systemic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C3889979 BXGD020015 Periodic Fever Syndrome Pathological Conditions, Signs and Symptoms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4524856 BXGD023113 Refractory Classic Hodgkin Lymphoma
C4529962 BXGD023178 Fatty Liver Disease
C4708596 BXGD023728 Trisomy 1q syndrome
C4721444 BXGD023742 Burkitt Leukemia Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C4721532 BXGD023752 Lymphoma, Non-Hodgkin, Familial Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721579 BXGD023759 Secondary malignant neoplasm of colon and/or rectum Digestive System Diseases; Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4727985 BXGD023880 Ewing-like sarcoma
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002570 2-Decanone 156.27
BXGC0003456 1,4-Benzoquinone 108.09
BXGC0003817 Miltiorone 282.38
BXGC0004145 2,3-Heptanedione 128.17
BXGC0004206 3-Methyl-1,2-cyclopentanedione 112.13
BXGC0004245 2,3-Pentanedione 100.12
BXGC0004280 2,4-Pentanedione 100.12
BXGC0004569 Benzophenone 182.22
BXGC0005697 2,3-Butanedione 86.09
BXGC0006021 3-Methyl-1,2-cyclohexanedione 126.15
BXGC0007060 1-Phenyl-1,2-propanedione 148.16
BXGC0007542 11-Deoxoglycyrrhetinic acid 456.7
BXGC0011627 Glycyrrhetic acid 470.69
BXGC0021948 Bavachinin A 338.15
BXGC0028001 Beta-Lapachone 242.09
BXGC0031291 Tanshinone Iia Sulfonate 373.07
BXGC0032126 Alisol A 490.37
BXGC0033130 Benzoin 212.08
BXGC0036541 Dibenzoylmethane 224.08
BXGC0037599 Tanshinone Iia 294.13
BXGC0039579 Methyl Glycyrrhetinate 484.36
BXGC0043272 alisol A 24-acetate 532.38
BXGC0050317 Acetoxolone 512.35
BXGC0050651 Cryptotanshinone 296.14
BXGC0051976 n.a 474.37
BXGC0052948 Tanshinone I 276.08
BXGC0053767 Dihydrotanshinone I 278.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein