Showing entry for Adenylate cyclase type 5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005386
Protein NameAdenylate cyclase type 5
Uniport IdO95622
GeneADCY5
Gene Id111
DomainAC_N; DUF1053; Guanylate_cyc
Pfam PF16214   PF06327   PF00211  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01522 Endocrine resistance
3. Environmental Information Processing 3.2 Signal transduction hsa04015 Rap1 signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04072 Phospholipase D signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04114 Oocyte meiosis
5. Organismal Systems 5.9 Aging hsa04211 Longevity regulating pathway
5. Organismal Systems 5.9 Aging hsa04213 Longevity regulating pathway - multiple species
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
3. Environmental Information Processing 3.2 Signal transduction hsa04371 Apelin signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04540 Gap junction
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
5. Organismal Systems 5.10 Environmental adaptation hsa04713 Circadian entrainment
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
5. Organismal Systems 5.6 Nervous system hsa04723 Retrograde endocannabinoid signaling
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
5. Organismal Systems 5.6 Nervous system hsa04725 Cholinergic synapse
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
5. Organismal Systems 5.6 Nervous system hsa04727 GABAergic synapse
5. Organismal Systems 5.6 Nervous system hsa04728 Dopaminergic synapse
5. Organismal Systems 5.7 Sensory system hsa04750 Inflammatory mediator regulation of TRP channels
5. Organismal Systems 5.2 Endocrine system hsa04911 Insulin secretion
5. Organismal Systems 5.2 Endocrine system hsa04912 GnRH signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04913 Ovarian steroidogenesis
5. Organismal Systems 5.2 Endocrine system hsa04914 Progesterone-mediated oocyte maturation
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04916 Melanogenesis
5. Organismal Systems 5.2 Endocrine system hsa04918 Thyroid hormone synthesis
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04923 Regulation of lipolysis in adipocytes
5. Organismal Systems 5.2 Endocrine system hsa04924 Renin secretion
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
5. Organismal Systems 5.2 Endocrine system hsa04926 Relaxin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04927 Cortisol synthesis and secretion
5. Organismal Systems 5.2 Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
5. Organismal Systems 5.4 Digestive system hsa04970 Salivary secretion
5. Organismal Systems 5.4 Digestive system hsa04971 Gastric acid secretion
5. Organismal Systems 5.4 Digestive system hsa04972 Pancreatic secretion
5. Organismal Systems 5.4 Digestive system hsa04976 Bile secretion
6. Human Diseases 6.4 Neurodegenerative diseases hsa05012 Parkinson disease
6. Human Diseases 6.5 Substance dependence hsa05030 Cocaine addiction
6. Human Diseases 6.5 Substance dependence hsa05031 Amphetamine addiction
6. Human Diseases 6.5 Substance dependence hsa05032 Morphine addiction
6. Human Diseases 6.5 Substance dependence hsa05034 Alcoholism
6. Human Diseases 6.9 Infectious diseases: Viral hsa05163 Human cytomegalovirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007190 activation of adenylate cyclase activity
Biological Process GO:0034199 activation of protein kinase A activity
Biological Process GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway
Biological Process GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process GO:0006171 cAMP biosynthetic process
Biological Process GO:1904322 cellular response to forskolin
Biological Process GO:0071377 cellular response to glucagon stimulus
Biological Process GO:0001973 G protein-coupled adenosine receptor signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0050885 neuromuscular process controlling balance
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process GO:0003091 renal water homeostasis
molecular function GO:0004016 adenylate cyclase activity
molecular function GO:0008179 adenylate cyclase binding
molecular function GO:0005524 ATP binding
molecular function GO:0046872 metal ion binding
molecular function GO:0097110 scaffold protein binding
cellular component GO:0005929 cilium
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0045111 intermediate filament cytoskeleton
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-111885 Opioid Signalling
R-HSA-111885 Opioid Signalling
R-HSA-111931 PKA-mediated phosphorylation of CREB
R-HSA-111933 Calmodulin induced events
R-HSA-111996 Ca-dependent events
R-HSA-111997 CaM pathway
R-HSA-112040 G-protein mediated events
R-HSA-112040 G-protein mediated events
R-HSA-112043 PLC beta mediated events
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
R-HSA-1430728 Metabolism
R-HSA-1489509 DAG and IP3 signaling
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-163359 Glucagon signaling in metabolic regulation
R-HSA-163615 PKA activation
R-HSA-163685 Integration of energy metabolism
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-164378 PKA activation in glucagon signalling
R-HSA-170660 Adenylate cyclase activating pathway
R-HSA-170670 Adenylate cyclase inhibitory pathway
R-HSA-170670 Adenylate cyclase inhibitory pathway
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-382551 Transport of small molecules
R-HSA-388396 GPCR downstream signalling
R-HSA-388396 GPCR downstream signalling
R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-HSA-418555 G alpha (s) signalling events
R-HSA-418555 G alpha (s) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-422356 Regulation of insulin secretion
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-445717 Aquaporin-mediated transport
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5663205 Infectious disease
R-HSA-5663205 Infectious disease
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9658195 Leishmania infection
R-HSA-9658195 Leishmania infection
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664323 FCGR3A-mediated IL10 synthesis
R-HSA-9664433 Leishmania parasite growth and survival
R-HSA-9664433 Leishmania parasite growth and survival
R-HSA-977443 GABA receptor activation
R-HSA-977443 GABA receptor activation
R-HSA-977444 GABA B receptor activation
R-HSA-977444 GABA B receptor activation
R-HSA-991365 Activation of GABAB receptors
R-HSA-991365 Activation of GABAB receptors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001787 BXGD000076 Osteoporosis, Age-Related Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0005612 BXGD000317 Birth Weight Pathological Conditions, Signs and Symptoms
C0005890 BXGD000345 Body Height
C0007097 BXGD000424 Carcinoma Neoplasms
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007789 BXGD000488 Cerebral Palsy Nervous System Diseases
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012833 BXGD000795 Dizziness Pathological Conditions, Signs and Symptoms
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0016059 BXGD001043 Fibrosis Pathological Conditions, Signs and Symptoms
C0017741 BXGD001149 Glucose tolerance test
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024667 BXGD001794 Animal Mammary Neoplasms Neoplasms; Animal Diseases
C0024668 BXGD001795 Mammary Neoplasms, Experimental Neoplasms
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028850 BXGD002092 Ocular Motility Disorders Eye Diseases; Nervous System Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029459 BXGD002159 Osteoporosis, Senile Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033141 BXGD002400 Cardiomyopathies, Primary Cardiovascular Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036529 BXGD002624 Myocardial Diseases, Secondary Cardiovascular Diseases
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152115 BXGD003544 Lingual-Facial-Buccal Dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0158683 BXGD003899 Polycystic liver disease Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Neoplasms
C0200635 BXGD004041 Lymphocyte Count measurement
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0205682 BXGD004105 Waist-Hip Ratio
C0205696 BXGD004107 Anaplastic carcinoma Neoplasms
C0205697 BXGD004108 Carcinoma, Spindle-Cell Neoplasms
C0205698 BXGD004109 Undifferentiated carcinoma Neoplasms
C0205699 BXGD004110 Carcinomatosis Neoplasms
C0221163 BXGD004395 Motor Disorders Mental Disorders
C0234366 BXGD004652 Ataxic
C0234379 BXGD004662 Resting Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0242698 BXGD005189 Ventricular Dysfunction, Left Cardiovascular Diseases
C0270742 BXGD006097 Athetoid cerebral palsy Nervous System Diseases
C0270871 BXGD006126 Facial Myokymia Nervous System Diseases; Stomatognathic Diseases
C0271270 BXGD006178 Oculovestibuloauditory syndrome Eye Diseases; Nervous System Diseases; Cardiovascular Diseases
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0338488 BXGD007189 Alternating hemiplegia of childhood Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0392885 BXGD008071 High density lipoprotein measurement
C0393584 BXGD008099 Benign Hereditary Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0428568 BXGD008633 Fasting blood glucose measurement
C0432072 BXGD008718 Dysmorphic features
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0596887 BXGD009648 mathematical ability
C0684219 BXGD009789 Myokymia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751406 BXGD010428 Post-Traumatic Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0871388 BXGD011314 social stress Behavior and Behavior Mechanisms
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1257925 BXGD011814 Mammary Carcinoma, Animal Neoplasms; Animal Diseases
C1261430 BXGD011853 Fasting blood sugar result
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1305855 BXGD012348 Body mass index
C1445957 BXGD013081 Serum total cholesterol measurement
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1611743 BXGD013456 Familial (FPAH)
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1834570 BXGD013981 Myoclonic dystonia Nervous System Diseases
C1837658 BXGD014257 Gross motor development delay Mental Disorders
C1838391 BXGD014313 Limb hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1842364 BXGD014511 Central hypotonia
C1847627 BXGD014878 Dyskinesia, Familial, with Facial Myokymia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859098 BXGD015850 Chorea, Benign Familial Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3489733 BXGD018945 Oculomotor apraxia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases; Behavior and Behavior Mechanisms; Cardiovascular Diseases
C3887506 BXGD019886 Hyperkinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021898 BXGD020831 Upper limb hypertonia
C4551854 BXGD023422 HYPOPLASTIC LEFT HEART SYNDROME 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4707562 BXGD023717 Autoimmune encephalopathy with parasomnia and obstructive sleep apnea Respiratory Tract Diseases; Nervous System Diseases; Endocrine System Diseases; Mental Disorders
C4728082 BXGD023886 Severe hypoglycaemia
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0005871 Dopamine 153.18
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein