Showing entry for Complement factor D


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005638
Protein NameComplement factor D
Uniport IdP00746
GeneCFD
Gene Id1675
DomainTrypsin
Pfam PF00089  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05150 Staphylococcus aureus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006956 complement activation
Biological Process GO:0006957 complement activation, alternative pathway
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0007219 Notch signaling pathway
Biological Process GO:0002576 platelet degranulation
Biological Process GO:0006508 proteolysis
molecular function GO:0004252 serine-type endopeptidase activity
molecular function GO:0008236 serine-type peptidase activity
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0031093 platelet alpha granule lumen
cellular component GO:0034774 secretory granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-114608 Platelet degranulation
R-HSA-166658 Complement cascade
R-HSA-166663 Initial triggering of complement
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-173736 Alternative complement activation
R-HSA-6798695 Neutrophil degranulation
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003257 BXGD000189 Antibody Deficiency Syndrome Immune System Diseases
C0003493 BXGD000199 Aortic Diseases Cardiovascular Diseases
C0003907 BXGD000240 Arthus Reaction Immune System Diseases
C0003949 BXGD000242 Asbestosis Respiratory Tract Diseases; Occupational Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007766 BXGD000478 Intracranial Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0008733 BXGD000569 Chylothorax Respiratory Tract Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010093 BXGD000652 Corpus Luteum Cyst Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0016065 BXGD001046 Polyostotic fibrous dysplasia Musculoskeletal Diseases
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019100 BXGD001283 Severe Dengue Infections
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0023212 BXGD001616 Left-Sided Heart Failure Cardiovascular Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024790 BXGD001804 Paroxysmal nocturnal hemoglobinuria Hemic and Lymphatic Diseases
C0025303 BXGD001858 Meningococcal Infections Infections
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029927 BXGD002182 Ovarian Cysts Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0035305 BXGD002529 Retinal Detachment Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0037315 BXGD002687 Sleep Apnea Syndromes Respiratory Tract Diseases; Nervous System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0085396 BXGD003162 Neisseriaceae Infections Infections
C0152419 BXGD003585 Interrupted aortic arch Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0235527 BXGD004753 Heart Failure, Right-Sided Cardiovascular Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242292 BXGD005146 McCune-Albright Syndrome Musculoskeletal Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0259779 BXGD005218 Fibrous Dysplasia
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0272242 BXGD006330 Complement deficiency disease Immune System Diseases; Hemic and Lymphatic Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0332853 BXGD006901 Anastomosis
C0333099 BXGD006921 Fusiform Aneurysm Cardiovascular Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0398764 BXGD008227 Complement Factor D Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0851883 BXGD010928 Neisseria infection Infections
C0917996 BXGD011425 Cerebral Aneurysm Nervous System Diseases; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1536085 BXGD013334 Geographic Atrophy Eye Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1704377 BXGD013553 Bright Disease Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1844383 BXGD014628 Recurrent bacterial infection Infections
C1845050 BXGD014703 PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1861403 BXGD016045 Variable expressivity
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1959583 BXGD016637 Myocardial Failure Cardiovascular Diseases
C1961112 BXGD016674 Heart Decompensation Cardiovascular Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2745963 BXGD017571 Kashin-Beck Disease Musculoskeletal Diseases
C2930617 BXGD017888 Pulmonary Fibrosis - from Asbestos Exposure Respiratory Tract Diseases; Occupational Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3887938 BXGD019929 Deuteranomaly Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4721507 BXGD023747 Alveolitis, Fibrosing Respiratory Tract Diseases
C4732730 BXGD023895 Blood spots
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0001380 Succinic acid 118.09
BXGC0006697 Water 18.02
BXGC0021950 2-aminobenzyl alcohol 123.07
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein