Showing entry for Atrial natriuretic peptide receptor 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008185
Protein NameAtrial natriuretic peptide receptor 1
Uniport IdP16066
GeneNPR1
Gene Id4881
DomainANF_receptor; Guanylate_cyc; Pkinase_Tyr
Pfam PF01094   PF00211   PF07714  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04923 Regulation of lipolysis in adipocytes
5. Organismal Systems 5.2 Endocrine system hsa04924 Renin secretion
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007589 body fluid secretion
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0006182 cGMP biosynthetic process
Biological Process GO:0019934 cGMP-mediated signaling
Biological Process GO:0042417 dopamine metabolic process
Biological Process GO:0016525 negative regulation of angiogenesis
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0048662 negative regulation of smooth muscle cell proliferation
Biological Process GO:0010753 positive regulation of cGMP-mediated signaling
Biological Process GO:0035815 positive regulation of renal sodium excretion
Biological Process GO:0035810 positive regulation of urine volume
Biological Process GO:0007168 receptor guanylyl cyclase signaling pathway
Biological Process GO:0008217 regulation of blood pressure
Biological Process GO:0097746 regulation of blood vessel diameter
Biological Process GO:1903779 regulation of cardiac conduction
Biological Process GO:0043114 regulation of vascular permeability
Biological Process GO:0007165 signal transduction
molecular function GO:0005524 ATP binding
molecular function GO:0008528 G protein-coupled peptide receptor activity
molecular function GO:0005525 GTP binding
molecular function GO:0004383 guanylate cyclase activity
molecular function GO:0042562 hormone binding
molecular function GO:0016941 natriuretic peptide receptor activity
molecular function GO:0017046 peptide hormone binding
molecular function GO:0001653 peptide receptor activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0019901 protein kinase binding
cellular component GO:0016021 integral component of membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-397014 Muscle contraction
R-HSA-5576891 Cardiac conduction
R-HSA-5578768 Physiological factors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004565 BXGD000276 Melanoma, B16 Neoplasms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0016059 BXGD001043 Fibrosis Pathological Conditions, Signs and Symptoms
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019269 BXGD001310 Hermaphroditism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0020305 BXGD001374 Hydrops Fetalis Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023212 BXGD001616 Left-Sided Heart Failure Cardiovascular Diseases
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033581 BXGD002410 prostatitis Male Urogenital Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152105 BXGD003541 Hypertensive heart disease Cardiovascular Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0155877 BXGD003830 Allergic asthma Respiratory Tract Diseases; Immune System Diseases
C0234230 BXGD004635 Pain, Burning Pathological Conditions, Signs and Symptoms
C0234238 BXGD004637 Ache Pathological Conditions, Signs and Symptoms
C0234254 BXGD004648 Radiating pain Pathological Conditions, Signs and Symptoms
C0235527 BXGD004753 Heart Failure, Right-Sided Cardiovascular Diseases
C0236664 BXGD004818 Alcohol-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0242350 BXGD005154 Erectile dysfunction Male Urogenital Diseases; Mental Disorders
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243050 BXGD005212 Cardiovascular Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0339467 BXGD007248 Proliferative retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0349566 BXGD007928 Squamous cell carcinoma of tongue Neoplasms; Stomatognathic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0428791 BXGD008635 Aortic valve calcification Nutritional and Metabolic Diseases; Cardiovascular Diseases
C0428886 BXGD008640 Mean blood pressure
C0458257 BXGD008905 Pain, Splitting Pathological Conditions, Signs and Symptoms
C0458259 BXGD008906 Pain, Crushing Pathological Conditions, Signs and Symptoms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0751407 BXGD010429 Pain, Migratory Pathological Conditions, Signs and Symptoms
C0751408 BXGD010430 Suffering, Physical Pathological Conditions, Signs and Symptoms
C0871470 BXGD011316 Systolic Pressure
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1383860 BXGD012935 Cardiac Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1868938 BXGD016542 End stage cardiac failure
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1959583 BXGD016637 Myocardial Failure Cardiovascular Diseases
C1961112 BXGD016674 Heart Decompensation Cardiovascular Diseases
C2945695 BXGD018187 Limb ischemia
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0051780 Isosorbide Dinitrate 236.03
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein