adisease

Showing entry for Limb ischemia

General Disease Information
BXGD Id	BXGD018187
Disease Name	Limb ischemia
Disease CUI Id	C2945695
MeSH Codes
Disease Class Name
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00244	BXGT003902	Copper transport protein ATOX1	475	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O15389	BXGT004161	Sialic acid-binding Ig-like lectin 5	8778	reviewed	Receptor
O43854	BXGT004630	EGF-like repeat and discoidin I-like domain-containing protein 3	10085	reviewed	Enzyme
O60566	BXGT004884	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	701	reviewed	Kinase
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O75475	BXGT005130	PC4 and SFRS1-interacting protein	11168	reviewed	Signaling
O95390	BXGT005377	Growth/differentiation factor 11	10220	reviewed	Signaling
O95398	BXGT005378	Rap guanine nucleotide exchange factor 3	10411	reviewed	Enzyme modulator
P00734	BXGT005630	Prothrombin	2147	reviewed	Enzyme
P00749	BXGT005641	Urokinase-type plasminogen activator	5328	reviewed	Enzyme
P01011	BXGT005715	Alpha-1-antichymotrypsin	12	reviewed	Enzyme modulator
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P02775	BXGT005960	Platelet basic protein	5473	reviewed	Signaling
P02786	BXGT005961	Transferrin receptor protein 1	7037	reviewed	Enzyme
P04275	BXGT006180	von Willebrand factor	7450	reviewed	Enzyme modulator
P05107	BXGT006316	Integrin beta-2	3689	reviewed	Receptor
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05230	BXGT006344	Fibroblast growth factor 1	2246	reviewed	Signaling
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06744	BXGT006494	Glucose-6-phosphate isomerase	2821	reviewed	Enzyme
P06870	BXGT006518	Kallikrein-1	3816	reviewed	Enzyme
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09958	BXGT006950	Furin	5045	reviewed	Enzyme
P11215	BXGT007672	Integrin alpha-M	3684	reviewed
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P14210	BXGT007994	Hepatocyte growth factor	3082	reviewed	Enzyme
P14784	BXGT008054	Interleukin-2 receptor subunit beta	3560	reviewed	Receptor
P15311	BXGT008106	Ezrin	7430	reviewed	Cellular structure
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16050	BXGT008184	Arachidonate 15-lipoxygenase	246	reviewed	Enzyme
P16066	BXGT008185	Atrial natriuretic peptide receptor 1	4881	reviewed	Kinase
P20309	BXGT008562	Muscarinic acetylcholine receptor M3	1131	reviewed	G-protein coupled receptor
P20701	BXGT008591	Integrin alpha-L	3683	reviewed
P23297	BXGT008848	Protein S100-A1	6271	reviewed	Calcium-binding protein
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P25098	BXGT009015	Beta-adrenergic receptor kinase 1	156	reviewed	Kinase
P25103	BXGT009020	Substance-P receptor	6869	reviewed	G-protein coupled receptor
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P29466	BXGT009349	Caspase-1	834	reviewed	Enzyme
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P29622	BXGT009370	Kallistatin	5267	reviewed	Enzyme modulator
P30536	BXGT009435	Translocator protein	706	reviewed
P30989	BXGT009492	Neurotensin receptor type 1	4923	reviewed	G-protein coupled receptor
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P33261	BXGT009707	Cytochrome P450 2C19	1557	reviewed
P35610	BXGT009855	Sterol O-acyltransferase 1	6646	reviewed	Enzyme
P35754	BXGT009863	Glutaredoxin-1	2745	reviewed
P35968	BXGT009887	Vascular endothelial growth factor receptor 2	3791	reviewed	Kinase
P39060	BXGT010088	Collagen alpha-1(XVIII) chain	80781	reviewed
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49767	BXGT010739	Vascular endothelial growth factor C	7424	reviewed	Signaling
P49913	BXGT010761	Cathelicidin antimicrobial peptide	820	reviewed
P50750	BXGT010818	Cyclin-dependent kinase 9	1025	reviewed	Kinase
P51790	BXGT010890	H(+)/Cl(-) exchange transporter 3	1182	reviewed	Ion channel
P52799	BXGT010956	Ephrin-B2	1948	reviewed	Signaling
P54760	BXGT011075	Ephrin type-B receptor 4	2050	reviewed	Kinase
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P62736	BXGT011452	Actin, aortic smooth muscle	59	reviewed	Cellular structure
P62937	BXGT011471	Peptidyl-prolyl cis-trans isomerase A	5478	reviewed
P63000	BXGT011481	Ras-related C3 botulinum toxin substrate 1	5879	reviewed	Enzyme modulator
P63261	BXGT011512	Actin, cytoplasmic 2	71	reviewed	Cellular structure
Q02763	BXGT012667	Angiopoietin-1 receptor	7010	reviewed	Kinase
Q15109	BXGT013537	Advanced glycosylation end product-specific receptor	177	reviewed	Receptor
Q15389	BXGT013564	Angiopoietin-1	284	reviewed	Signaling
Q15910	BXGT013612	Histone-lysine N-methyltransferase EZH2	2146	reviewed	Epigenetic regulator
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q92945	BXGT019397	Far upstream element-binding protein 2	8570	reviewed	Enzyme
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q99814	BXGT019965	Endothelial PAS domain-containing protein 1	2034	reviewed	Transcription factor
Q99836	BXGT019970	Myeloid differentiation primary response protein MyD88	4615	reviewed	Enzyme modulator
Q9C000	BXGT020206	NACHT, LRR and PYD domains-containing protein 1	22861	reviewed
Q9H3M7	BXGT020462	Thioredoxin-interacting protein	10628	reviewed
Q9H6Z9	BXGT020488	Egl nine homolog 3	112399	reviewed
Q9UM07	BXGT021771	Protein-arginine deiminase type-4	23569	reviewed
Q9Y286	BXGT022225	Sialic acid-binding Ig-like lectin 7	27036	reviewed	Receptor
P25054	BXGT022961	Adenomatous polyposis coli protein	324	reviewed
Q9H040	BXGT024831	SprT-like domain-containing protein Spartan	83932	reviewed
Q8NI99	BXGT025986	Angiopoietin-related protein 6	83854	reviewed	Signaling

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}