Showing entry for Tyrosine-protein kinase Fer


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008246
Protein NameTyrosine-protein kinase Fer
Uniport IdP16591
GeneFER
Gene Id2241
DomainFCH; Pkinase_Tyr; SH2
Pfam PF00611   PF07714   PF00017  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04520 Adherens junction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031532 actin cytoskeleton reorganization
Biological Process GO:0007155 cell adhesion
Biological Process GO:0044331 cell-cell adhesion mediated by cadherin
Biological Process GO:0030154 cell differentiation
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
Biological Process GO:0034614 cellular response to reactive oxygen species
Biological Process GO:0006935 chemotaxis
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0050904 diapedesis
Biological Process GO:0035426 extracellular matrix-cell signaling
Biological Process GO:0038095 Fc-epsilon receptor signaling pathway
Biological Process GO:0045087 innate immune response
Biological Process GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase
Biological Process GO:0070102 interleukin-6-mediated signaling pathway
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0038109 Kit signaling pathway
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0033007 negative regulation of mast cell activation involved in immune response
Biological Process GO:0038083 peptidyl-tyrosine autophosphorylation
Biological Process GO:0018108 peptidyl-tyrosine phosphorylation
Biological Process GO:0048008 platelet-derived growth factor receptor signaling pathway
Biological Process GO:0030838 positive regulation of actin filament polymerization
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0042058 regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0010762 regulation of fibroblast migration
Biological Process GO:0010591 regulation of lamellipodium assembly
Biological Process GO:0043304 regulation of mast cell degranulation
Biological Process GO:0001932 regulation of protein phosphorylation
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0036119 response to platelet-derived growth factor
Biological Process GO:0034446 substrate adhesion-dependent cell spreading
Biological Process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Biological Process GO:0007260 tyrosine phosphorylation of STAT protein
molecular function GO:0005524 ATP binding
molecular function GO:0005154 epidermal growth factor receptor binding
molecular function GO:0008289 lipid binding
molecular function GO:0004715 non-membrane spanning protein tyrosine kinase activity
molecular function GO:0008157 protein phosphatase 1 binding
molecular function GO:0004713 protein tyrosine kinase activity
molecular function GO:0005102 signaling receptor binding
cellular component GO:0005938 cell cortex
cellular component GO:0030054 cell junction
cellular component GO:0042995 cell projection
cellular component GO:0005737 cytoplasm
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-162582 Signal Transduction
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004626 BXGD000283 Pneumonia, Bacterial Infections; Respiratory Tract Diseases
C0005890 BXGD000345 Body Height
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023508 BXGD001675 White Blood Cell Count procedure
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0036983 BXGD002652 Septic Shock Pathological Conditions, Signs and Symptoms; Infections
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0040420 BXGD002861 Tonometry
C0079774 BXGD003101 Peripheral T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0343401 BXGD007623 MRSA - Methicillin resistant Staphylococcus aureus infection Infections
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346163 BXGD007785 Endometrioid carcinoma ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0489786 BXGD009018 Height
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0871470 BXGD011316 Systolic Pressure
C1261473 BXGD011855 Sarcoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1519383 BXGD013237 Smoking Behaviors Behavior and Behavior Mechanisms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1832828 BXGD013876 Deafness, Autosomal Recessive 9 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3711374 BXGD019382 Nonsyndromic Deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C4273680 BXGD022335 Autosomal recessive limb girdle muscular dystrophy type 2B
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0012352 Chelerythrine 348.12
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein