Showing entry for 3-oxo-5-alpha-steroid 4-dehydrogenase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008400
Protein Name3-oxo-5-alpha-steroid 4-dehydrogenase 1
Uniport IdP18405
GeneSRD5A1
Gene Id6715
DomainSteroid_dh
Pfam PF02544  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00140 Steroid hormone biosynthesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006702 androgen biosynthetic process
Biological Process GO:0006710 androgen catabolic process
Biological Process GO:0060348 bone development
Biological Process GO:0030154 cell differentiation
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0071549 cellular response to dexamethasone stimulus
Biological Process GO:0071872 cellular response to epinephrine stimulus
Biological Process GO:0071392 cellular response to estradiol stimulus
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0009267 cellular response to starvation
Biological Process GO:0071394 cellular response to testosterone stimulus
Biological Process GO:0021987 cerebral cortex development
Biological Process GO:0042747 circadian sleep/wake cycle, REM sleep
Biological Process GO:0016101 diterpenoid metabolic process
Biological Process GO:0030540 female genitalia development
Biological Process GO:0021766 hippocampus development
Biological Process GO:0021854 hypothalamus development
Biological Process GO:0001889 liver development
Biological Process GO:0030539 male genitalia development
Biological Process GO:0008584 male gonad development
Biological Process GO:0021983 pituitary gland development
Biological Process GO:0042448 progesterone metabolic process
Biological Process GO:0042493 response to drug
Biological Process GO:0043627 response to estrogen
Biological Process GO:0032354 response to follicle-stimulating hormone
Biological Process GO:0060992 response to fungicide
Biological Process GO:0060416 response to growth hormone
Biological Process GO:0014850 response to muscle activity
Biological Process GO:0042428 serotonin metabolic process
Biological Process GO:0007530 sex determination
Biological Process GO:0021510 spinal cord development
Biological Process GO:0006694 steroid biosynthetic process
Biological Process GO:0021794 thalamus development
Biological Process GO:0001655 urogenital system development
molecular function GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity
molecular function GO:0033218 amide binding
molecular function GO:0047751 cholestenone 5-alpha-reductase activity
molecular function GO:0009055 electron transfer activity
molecular function GO:0070402 NADPH binding
molecular function GO:0016491 oxidoreductase activity
cellular component GO:0070852 cell body fiber
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0043209 myelin sheath
cellular component GO:0043025 neuronal cell body
cellular component GO:0048471 perinuclear region of cytoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-193048 Androgen biosynthesis
R-HSA-196071 Metabolism of steroid hormones
R-HSA-556833 Metabolism of lipids
R-HSA-8957322 Metabolism of steroids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008043 BXGD000513 Chiari-Frommel Syndrome Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0017638 BXGD001132 Glioma Neoplasms
C0020514 BXGD001414 Hyperprolactinemia Nervous System Diseases; Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030319 BXGD002208 Panic Disorder Mental Disorders
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0085096 BXGD003123 Peripheral Vascular Diseases Cardiovascular Diseases
C0162311 BXGD003935 Androgenetic Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0266470 BXGD005678 Cerebellar Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0268398 BXGD005933 Familial lichen amyloidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0278838 BXGD006599 Prostate cancer recurrent Neoplasms; Male Urogenital Diseases
C0338831 BXGD007216 Manic Mental Disorders
C0342513 BXGD007494 Idiopathic hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677984 BXGD009742 Locally Advanced Malignant Neoplasm
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0848558 BXGD010882 Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0936223 BXGD011477 Metastatic Prostate Carcinoma Neoplasms; Male Urogenital Diseases
C1136382 BXGD011717 Sclerocystic Ovaries Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1282496 BXGD012147 Metastasis from malignant tumor of prostate
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1691215 BXGD013491 Penile hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C2937421 BXGD018162 Prostatic Hyperplasia Male Urogenital Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4083212 BXGD022105 Alopecia, Male Pattern Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000681 Umbelliferone 162.14
BXGC0003611 Latex 416.57
BXGC0017757 Androstenedione 286.19
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein