Showing entry for Cyclic AMP-dependent transcription factor ATF-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008430
Protein NameCyclic AMP-dependent transcription factor ATF-1
Uniport IdP18846
GeneATF1
Gene Id466
DomainbZIP_1; pKID
Pfam PF00170   PF02173  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
6. Human Diseases 6.1 Cancers: Overview hsa05202 Transcriptional misregulation in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034622 cellular protein-containing complex assembly
Biological Process GO:0045740 positive regulation of DNA replication
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0032025 response to cobalt ion
Biological Process GO:0014070 response to organic cyclic compound
molecular function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function GO:0003700 DNA-binding transcription factor activity
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0042802 identical protein binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
cellular component GO:1990590 ATF1-ATF4 transcription factor complex
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005667 transcription regulator complex
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-166520 Signaling by NTRKs
R-HSA-166520 Signaling by NTRKs
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-198725 Nuclear Events (kinase and transcription factor activation)
R-HSA-198725 Nuclear Events (kinase and transcription factor activation)
R-HSA-199920 CREB phosphorylation
R-HSA-448424 Interleukin-17 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases
R-HSA-450294 MAP kinase activation
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9031628 NGF-stimulated transcription
R-HSA-9031628 NGF-stimulated transcription
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-975871 MyD88 cascade initiated on plasma membrane
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010606 BXGD000677 Adenoid Cystic Carcinoma Neoplasms
C0017185 BXGD001104 Gastrointestinal Neoplasms Digestive System Diseases; Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017654 BXGD001136 Glomerular Filtration Rate
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0022680 BXGD001576 Polycystic Kidney Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024694 BXGD001797 Mandibular Neoplasms Neoplasms; Musculoskeletal Diseases; Stomatognathic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027070 BXGD001967 Myoepithelioma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027766 BXGD002034 Nervous System Neoplasms Neoplasms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028259 BXGD002073 Nodule
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0036095 BXGD002576 Salivary Gland Neoplasms Neoplasms; Stomatognathic Diseases
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0079588 BXGD003084 Ichthyosis, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0206634 BXGD004199 Liposarcoma, Myxoid Neoplasms
C0206651 BXGD004215 Clear Cell Sarcoma of Soft Tissue Neoplasms
C0206681 BXGD004236 Adenocarcinoma, Clear Cell Neoplasms
C0220613 BXGD004297 Adult Soft Tissue Sarcoma
C0220645 BXGD004307 Childhood Soft Tissue Sarcoma
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278579 BXGD006537 Cervix carcinoma recurrent Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0334121 BXGD006996 Inflammatory Myofibroblastic Tumor Pathological Conditions, Signs and Symptoms
C0334509 BXGD007095 Clear cell sarcoma, of tendons and aponeuroses Neoplasms
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0346629 BXGD007831 Malignant neoplasm of large intestine Digestive System Diseases; Neoplasms
C0545074 BXGD009324 Myxoid/Round Cell Liposarcoma Neoplasms
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0553581 BXGD009400 Round cell sarcoma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0871470 BXGD011316 Systolic Pressure
C1136382 BXGD011717 Sclerocystic Ovaries Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1266127 BXGD011968 Histiocytoma, Angiomatoid Fibrous Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1302401 BXGD012303 Adenoma of large intestine Digestive System Diseases; Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1332198 BXGD012499 Adult Clear Cell Sarcoma of Soft Parts Neoplasms
C1332964 BXGD012564 Childhood Clear Cell Sarcoma of Soft Parts Neoplasms
C1333069 BXGD012590 Thymic Clear Cell Carcinoma Neoplasms; Hemic and Lymphatic Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1519689 BXGD013245 Tumor Promotion Pathological Conditions, Signs and Symptoms; Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1704327 BXGD013546 Bone Sarcoma Neoplasms; Musculoskeletal Diseases
C1720824 BXGD013686 Sudden Cardiac Arrest Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1837315 BXGD014218 COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2675481 BXGD017292 COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
C2677123 BXGD017364 COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
C2717836 BXGD017510 Steroid Sulfatase Deficiency Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3554460 BXGD019215 COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
C3898127 BXGD020061 Non-Metastatic Childhood Soft Tissue Sarcoma
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4316837 BXGD022706 Clear cell odontogenic carcinoma
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4551687 BXGD023392 Sarcoma of soft tissue Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0018772 Pseudoephedrine 165.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein