Showing entry for rRNA 2'-O-methyltransferase fibrillarin


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008729
Protein NamerRNA 2'-O-methyltransferase fibrillarin
Uniport IdP22087
GeneFBL
Gene Id2091
DomainFibrillarin
Pfam PF01269  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa03008 Ribosome biogenesis in eukaryotes
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000494 box C/D snoRNA 3'-end processing
Biological Process GO:1990258 histone glutamine methylation
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0031167 rRNA methylation
Biological Process GO:0006364 rRNA processing
Biological Process GO:0048254 snoRNA localization
molecular function GO:0051117 ATPase binding
molecular function GO:1990259 histone-glutamine methyltransferase activity
molecular function GO:0003723 RNA binding
molecular function GO:0008649 rRNA methyltransferase activity
molecular function GO:0001094 TFIID-class transcription factor complex binding
cellular component GO:0031428 box C/D snoRNP complex
cellular component GO:0015030 Cajal body
cellular component GO:0005694 chromosome
cellular component GO:0001651 dense fibrillar component
cellular component GO:0070062 extracellular exosome
cellular component GO:0001650 fibrillar center
cellular component GO:0001652 granular component
cellular component GO:0016020 membrane
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032040 small-subunit processome
Reactome
Pathway Id Pathway Name
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72312 rRNA processing
R-HSA-72312 rRNA processing
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-8868773 rRNA processing in the nucleus and cytosol
R-HSA-8953854 Metabolism of RNA
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014867 BXGD000964 Esophageal Varices Digestive System Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019156 BXGD001292 Hepatic Veno-Occlusive Disease Digestive System Diseases; Cardiovascular Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020433 BXGD001379 Hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020541 BXGD001424 Portal Hypertension Digestive System Diseases
C0020981 BXGD001474 Angioimmunoblastic Lymphadenopathy Immune System Diseases; Hemic and Lymphatic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0041327 BXGD002916 Tuberculosis, Pulmonary Infections; Respiratory Tract Diseases
C0042140 BXGD002963 Uterine Prolapse Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0042721 BXGD002997 Viral hepatitis Digestive System Diseases; Infections
C0042769 BXGD002999 Virus Diseases Infections
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0162309 BXGD003934 Adrenoleukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0206650 BXGD004214 Fibroadenoma Neoplasms
C0235950 BXGD004790 Zinc deficiency Nutritional and Metabolic Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0239981 BXGD005011 Hypoalbuminemia Hemic and Lymphatic Diseases
C0241910 BXGD005123 Autoimmune Chronic Hepatitis Digestive System Diseases; Immune System Diseases
C0242852 BXGD005197 Proliferative vitreoretinopathy Eye Diseases
C0276623 BXGD006433 Chronic viral hepatitis Digestive System Diseases
C0341439 BXGD007408 Chronic liver disease Digestive System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0451641 BXGD008821 Urolithiasis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0524909 BXGD009247 Hepatitis B, Chronic Digestive System Diseases; Infections
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0543697 BXGD009291 Mixed cryoglobulinemia Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0683342 BXGD009784 hazardous drinking
C0740394 BXGD009989 Hyperuricemia Pathological Conditions, Signs and Symptoms
C1134719 BXGD011688 Invasive Ductal Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1258039 BXGD011821 Henipavirus Infections Infections
C1266129 BXGD011970 Atypical Lipoma Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1333977 BXGD012663 Hepatitis B Virus-Related Hepatocellular Carcinoma
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1608426 BXGD013436 Compensated cirrhosis
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1698259 BXGD013514 HCV coinfection
C1861453 BXGD016049 Pseudohyperkalemia Cardiff Nutritional and Metabolic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2242656 BXGD016988 HBV coinfection
C2347126 BXGD017036 Microscopic Polyarteritis Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C2364016 BXGD017122 Systemic sclerosis [scleroderma]
C2711110 BXGD017477 Hepatitis B and hepatitis C Digestive System Diseases; Infections
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3495801 BXGD019004 Granulomatosis with polyangiitis Respiratory Tract Diseases; Immune System Diseases; Cardiovascular Diseases
C3826157 BXGD019715 Hypertension in children
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4225412 BXGD022268 Spondylo-ocular syndrome
C4529962 BXGD023178 Fatty Liver Disease
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4721555 BXGD023755 Autoimmune hepatitis Digestive System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0017352 Methylthioadenosine 297.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein