protein

Showing entry for Sodium-dependent serotonin transporter

General Target Information
BXGT Id	BXGT009565
Protein Name	Sodium-dependent serotonin transporter
Uniport Id	P31652
Gene	Slc6a4
Gene Id	25553
Domain	5HT_transport_N; SNF
Pfam	PF03491 PF00209
Organism	Rattus norvegicus (Rat)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0007420	brain development
Biological Process	GO:0048854	brain morphogenesis
Biological Process	GO:0071321	cellular response to cGMP
Biological Process	GO:0071310	cellular response to organic substance
Biological Process	GO:0071300	cellular response to retinoic acid
Biological Process	GO:0007623	circadian rhythm
Biological Process	GO:0007626	locomotory behavior
Biological Process	GO:0007613	memory
Biological Process	GO:0015844	monoamine transport
Biological Process	GO:0021941	negative regulation of cerebellar granule cell precursor proliferation
Biological Process	GO:0045665	negative regulation of neuron differentiation
Biological Process	GO:0046621	negative regulation of organ growth
Biological Process	GO:0032227	negative regulation of synaptic transmission, dopaminergic
Biological Process	GO:0098810	neurotransmitter reuptake
Biological Process	GO:0045787	positive regulation of cell cycle
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0014064	positive regulation of serotonin secretion
Biological Process	GO:0090067	regulation of thalamus size
Biological Process	GO:0042493	response to drug
Biological Process	GO:0032355	response to estradiol
Biological Process	GO:0001666	response to hypoxia
Biological Process	GO:0007584	response to nutrient
Biological Process	GO:0010033	response to organic substance
Biological Process	GO:0009636	response to toxic substance
Biological Process	GO:0006837	serotonin transport
Biological Process	GO:0051610	serotonin uptake
Biological Process	GO:0035176	social behavior
Biological Process	GO:0042713	sperm ejaculation
Biological Process	GO:0042310	vasoconstriction
molecular function	GO:0051015	actin filament binding
molecular function	GO:0019811	cocaine binding
molecular function	GO:0042802	identical protein binding
molecular function	GO:0046872	metal ion binding
molecular function	GO:0008504	monoamine transmembrane transporter activity
molecular function	GO:0005326	neurotransmitter transmembrane transporter activity
molecular function	GO:0050998	nitric-oxide synthase binding
molecular function	GO:0005335	serotonin:sodium symporter activity
molecular function	GO:0051378	serotonin binding
molecular function	GO:0017075	syntaxin-1 binding
cellular component	GO:0012505	endomembrane system
cellular component	GO:0010008	endosome membrane
cellular component	GO:0005925	focal adhesion
cellular component	GO:0099055	integral component of postsynaptic membrane
cellular component	GO:0099056	integral component of presynaptic membrane
cellular component	GO:0045121	membrane raft
cellular component	GO:0043005	neuron projection
cellular component	GO:0005886	plasma membrane
cellular component	GO:0099154	serotonergic synapse
cellular component	GO:0045202	synapse

Reactome

Pathway Id	Pathway Name

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000191	Tyramine		137.18
BXGC0000538	(R)-Norepinephrine		169.18
BXGC0000548	Tryptamine		160.22
BXGC0001327	Nonacosan-8-one		165.23
BXGC0003196	Aripiprazole		448.39
BXGC0005867	Serotonin		176.22
BXGC0005871	Dopamine		153.18
BXGC0014068	Amphetamine		135.1
BXGC0016891	Nortriptyline		263.17
BXGC0023869	Aquilarabietic acid H		314.19
BXGC0026391	Naloxone		327.15
BXGC0030110	(-)-ephedrinium		166.12
BXGC0030901	Morphine		285.14
BXGC0035865	(+)-Pentazocine		285.21
BXGC0042222	Propranolol		259.16
BXGC0042322	buprenorphine		467.3
BXGC0042510	Fluoxetine		309.13
BXGC0042574	Ibogaine		310.2
BXGC0044353	Hyperforin		536.39
BXGC0051494	Rel-Pentazocine		285.21

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}