Showing entry for Tyramine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000191
Compound NameTyramine
Structure
FormulaC8H11NO
InchiKeyDZGWFCGJZKJUFP-UHFFFAOYSA-N
SMILESNCCC1=CC=C(O)C=C1
InchiInChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
IUPAC
Molecular Weight137.18
Pubchem Id5610
Chembl IdCHEMBL11608
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB AEF
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P56817 BXGT011200 Beta-secretase 1 reviewed BACE1 Enzyme - - 2000000 -
B7TYB2 BXGT002270 Bla g 4 allergen variant 1 unreviewed - - - - 22200000
A0A1A9TAK5 BXGT023051 Noroxomaritidine/norcraugsodine reductase reviewed NR - - 5230000 - -
Binding DB 29135
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 5900 - - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 23000 - - -
reviewed BXGT009565 Sodium-dependent serotonin transporter reviewed Slc6a4 1556 - - -
reviewed BXGT008936 Sodium-dependent dopamine transporter reviewed Slc6a3 106 - - -
reviewed BXGT019728 Trace amine-associated receptor 1 reviewed G-protein coupled receptor TAAR1 34 - - -
reviewed BXGT009457 Guanine nucleotide-binding protein subunit alpha-15 reviewed Enzyme modulator GNA15 - - - >29902
reviewed BXGT019728 Trace amine-associated receptor 1 reviewed G-protein coupled receptor TAAR1 - 881.84 - -
reviewed BXGT019728 Trace amine-associated receptor 1 reviewed G-protein coupled receptor TAAR1 - - - 177.71
reviewed BXGT009457 Guanine nucleotide-binding protein subunit alpha-15 reviewed Enzyme modulator GNA15 - >29902 - -
reviewed BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 - - 2000000 -
reviewed BXGT019728 Trace amine-associated receptor 1 reviewed G-protein coupled receptor TAAR1 - - - 731
reviewed BXGT009731 Mu-type opioid receptor reviewed Oprm1 - - - >0.001000
reviewed BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 >35000 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 >17000 - - -
reviewed BXGT007632 Phenylethanolamine N-methyltransferase reviewed PNMT 294000 - - -
reviewed BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 390000 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 160000 - - -
reviewed BXGT010507 5-hydroxytryptamine receptor 3A reviewed Ion channel HTR3A - - - 26000
reviewed BXGT009493 5-hydroxytryptamine receptor 2B reviewed Htr2b - - 7943.28 -
CHEMBL CHEMBL11608
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 10000 nM
Q96RJ0 BXGT019728 Trace amine-associated receptor 1 reviewed G-protein coupled receptor TAAR1 EC50 '=' 177 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Km '=' 514000 nM
Q91Y77 BXGT019323 Monocarboxylate transporter 10 reviewed - Slc16a10 Activity '=' 20 %
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Potency - 28183 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 32642 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB Km '=' 104700 nM
Q9Y468 BXGT022270 Lethal(3)malignant brain tumor-like protein 1 reviewed Epigenetic regulator L3MBTL1 Potency '=' 12589 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 6513 nM
Q96RJ0 BXGT019728 Trace amine-associated receptor 1 reviewed G-protein coupled receptor TAAR1 EC50 '=' 731 nM
Q923Y8 BXGT019345 Trace amine-associated receptor 1 reviewed - Taar1 Activity - - -
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 35481 nM
P15101 BXGT008080 Dopamine beta-hydroxylase reviewed - DBH Ratio '=' 60000 -
P15101 BXGT008080 Dopamine beta-hydroxylase reviewed - DBH k cat '=' 85 s-1
P10938 BXGT007632 Phenylethanolamine N-methyltransferase reviewed - PNMT Ki '=' 294000 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 39810 nM
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 6 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '=' 160000 nM
P28565 BXGT009273 5-hydroxytryptamine receptor 1D reviewed - Htr1d Kd '=' 8511 nM
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Kd '=' 8511 nM
P35364 BXGT009819 5-hydroxytryptamine receptor 5A reviewed - Htr5a Kd '=' 8511 nM
P30940 BXGT009484 5-hydroxytryptamine receptor 1F reviewed - Htr1f Kd '=' 8511 nM
P14842 BXGT008059 5-hydroxytryptamine receptor 2A reviewed - Htr2a Kd '=' 8511 nM
P08909 BXGT006838 5-hydroxytryptamine receptor 2C reviewed - Htr2c Kd '=' 8511 nM
Q62758 BXGT016041 5-hydroxytryptamine receptor 4 reviewed - Htr4 Kd '=' 8511 nM
P30994 BXGT009493 5-hydroxytryptamine receptor 2B reviewed - Htr2b Kd '=' 8511 nM
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Kd '=' 8511 nM
Q9JJ16 BXGT020824 5-hydroxytryptamine receptor 3B reviewed - Htr3b Kd '=' 8511 nM
P31388 BXGT009532 5-hydroxytryptamine receptor 6 reviewed - Htr6 Kd '=' 8511 nM
P32305 BXGT009621 5-hydroxytryptamine receptor 7 reviewed - Htr7 Kd '=' 8511 nM
P35365 BXGT009820 5-hydroxytryptamine receptor 5B reviewed - Htr5b Kd '=' 8511 nM
P35563 BXGT009849 5-hydroxytryptamine receptor 3A reviewed - Htr3a Kd '=' 8511 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 7943 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 8199 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Vmax '=' 301 nmol/min/mg
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki '>' 17000 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Log 1/KL '=' -5 -
O15245 BXGT004141 Solute carrier family 22 member 1 reviewed Transporter SLC22A1 Activity '=' 107 uM
P15101 BXGT008080 Dopamine beta-hydroxylase reviewed - DBH k cat '=' 121 s-1
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 KL '=' 390000 nM
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ratio - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ratio - - -
P30994 BXGT009493 5-hydroxytryptamine receptor 2B reviewed - Htr2b Kd '=' 7943 nM
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki '>' 35000 nM
P21398 BXGT008645 Amine oxidase [flavin-containing] A reviewed - MAOA Km - - -
P56560 BXGT011180 Amine oxidase [flavin-containing] B reviewed - MAOB Km - - -
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 266 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB Vmax '=' 28 nmol/min/mg
P14679 BXGT008039 Tyrosinase reviewed Enzyme TYR Inhibition '=' 23 %
P15101 BXGT008080 Dopamine beta-hydroxylase reviewed - DBH Km '=' 2000000 nM
P21398 BXGT008645 Amine oxidase [flavin-containing] A reviewed - MAOA k cat - - -
P56560 BXGT011180 Amine oxidase [flavin-containing] B reviewed - MAOB k cat - - -
P33535 BXGT009731 Mu-type opioid receptor reviewed - Oprm1 EC50 '>' 0 -
P34975 BXGT009780 Kappa-type opioid receptor reviewed - Oprk1 EC50 '>' 0 -
P33533 BXGT009729 Delta-type opioid receptor reviewed - Oprd1 EC50 '>' 0 -
Q63089 BXGT016060 Solute carrier family 22 member 1 reviewed - Slc22a1 Activity - - -
P97266 BXGT012199 Mu-type opioid receptor reviewed - OPRM1 EC50 '>' 0 -
P41144 BXGT010224 Kappa-type opioid receptor reviewed - OPRK1 EC50 '>' 0 -
P33535 BXGT009731 Mu-type opioid receptor reviewed - Oprm1 Ratio '<' 0 -
P34975 BXGT009780 Kappa-type opioid receptor reviewed - Oprk1 Ratio '<' 0 -
P33533 BXGT009729 Delta-type opioid receptor reviewed - Oprd1 Ratio '<' 0 -
P46098 BXGT010507 5-hydroxytryptamine receptor 3A reviewed Ion channel HTR3A Activity - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 - - -
P56817 BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 Kd '=' 2000000 nM
Q96RJ0 BXGT019728 Trace amine-associated receptor 1 reviewed G-protein coupled receptor TAAR1 Emax '=' 91 %
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 39810 nM
P97266 BXGT012199 Mu-type opioid receptor reviewed - OPRM1 Ratio '<' 0 -
P41144 BXGT010224 Kappa-type opioid receptor reviewed - OPRK1 Ratio '<' 0 -
P46098 BXGT010507 5-hydroxytryptamine receptor 3A reviewed Ion channel HTR3A EC50 '=' 26000 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Km '=' 540000 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 751 nM
Q923Y9 BXGT019346 Trace amine-associated receptor 1 reviewed - Taar1 Activity - - -
P08482 BXGT006775 Muscarinic acetylcholine receptor M1 reviewed - Chrm1 Potency '=' 50 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 - - -
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 31622 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki '=' 390000 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Activity '=' 25 /s
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 59 %
O75751 BXGT005150 Solute carrier family 22 member 3 reviewed Transporter SLC22A3 Activity - - -
Q96RJ0 BXGT019728 Trace amine-associated receptor 1 reviewed G-protein coupled receptor TAAR1 IC50 '=' 881 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 85 %
Q923Y9 BXGT019346 Trace amine-associated receptor 1 reviewed - Taar1 EC50 '=' 69 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00054 Lemon Citrus limon Fruits
BXGF00056 Mandarin orange (Clementine, Tangerine) Citrus reticulata Fruits
BXGF00057 Sweet orange Citrus sinensis Fruits
BXGF00088 Barley Hordeum vulgare Cereals and cereal products
BXGF00130 Avocado Persea americana Vegetables
BXGF00141 Common pea Pisum sativum Pulses
BXGF00147 European plum Prunus domestica Fruits
BXGF00171 Garden tomato Solanum lycopersicum Vegetables
BXGF00173 Garden tomato (var.) Solanum lycopersicum var. lycopersicum Vegetables
BXGF00174 Eggplant Solanum melongena Vegetables
BXGF00175 Potato Solanum tuberosum Vegetables
BXGF00182 Cocoa bean Theobroma cacao Cocoa and cocoa products
BXGF00810 Cereals and cereal products Cereals and cereal products
BXGF00818 Herbs and Spices Herbs and Spices
BXGF00819 Pulses Pulses
BXGF00871 Citrus unshiu Citrus unshiu Medicinal Plant
BXGF00873 Polyalthia barnesii Polyalthia barnesii Others
BXGF01030 Striga lutea Striga lutea Medicinal Plant
BXGF01113 Crotalaria medicaginea Crotalaria medicaginea Medicinal Plant
BXGF01147 Chelidonium majus Chelidonium majus Medicinal Plant
BXGF01294 Eria alba Eria alba Others
BXGF01348 Sidastrum burrerense Sidastrum burrerense Others
BXGF01365 Psychotria st Psychotria st Others
BXGF01458 Ligularia altaica Ligularia altaica Others
BXGF01703 Dalbergia candenatensis Dalbergia candenatensis Medicinal Plant
BXGF01835 Dioscorea nipponica Dioscorea nipponica Medicinal Plant
BXGF01983 Yucca recurvifolia Yucca recurvifolia Human Edible Plant
BXGF02317 Krameria parvifolia Krameria parvifolia Others
BXGF02372 Aesculus turbinata Aesculus turbinata Medicinal Plant
BXGF02390 Argyreia speciosa Argyreia speciosa Medicinal Plant
BXGF02465 Vernonia profuga Vernonia profuga Others
BXGF02578 Artocarpus styracifolius Artocarpus styracifolius Human Edible Plant
BXGF02779 Swertia chinensis Swertia chinensis Medicinal Plant
BXGF02821 Forsythia giraldiana Forsythia giraldiana Others
BXGF02892 Dorstenia mannii Dorstenia mannii Medicinal Plant
BXGF03327 Citrus trifoliata Citrus trifoliata Human Edible Plant
BXGF03560 Alnus alnobetula Alnus alnobetula Others
BXGF03643 Cytisus scoparius Cytisus scoparius Medicinal Plant
BXGF04176 Fritillaria stenanthera Fritillaria stenanthera Others
BXGF05167 Allium victorialis Allium victorialis Medicinal Plant
BXGF05299 Corynandra viscosa Corynandra viscosa Medicinal Plant
BXGF05431 Citrus natsudaidai Citrus natsudaidai Human Edible Plant
BXGF05438 Calocephalus citreus Calocephalus citreus Others
BXGF05504 Silybum marianum Silybum marianum Medicinal Plant
BXGF05580 Genista pichisermolliana Genista pichisermolliana Others
BXGF05606 Eria floribunda Eria floribunda Others
BXGF05653 Kopsia teoi Kopsia teoi Others
BXGF05786 Rubus lambertianus Rubus lambertianus Medicinal Plant
BXGF05819 Citrus aurantium Citrus aurantium Medicinal Plant
BXGF06084 Brickellia cylindracea Brickellia cylindracea Others
BXGF06225 Stevia paniculata Stevia paniculata Others
BXGF06260 Dryopteris dilatata Dryopteris dilatata Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease