Showing entry for (R)-Norepinephrine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000538
Compound Name(R)-Norepinephrine
Structure
FormulaC8H11NO3
InchiKeySFLSHLFXELFNJZ-UHFFFAOYSA-N
SMILESNCC(O)C1=CC(O)=C(O)C=C1
InchiInChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2
IUPAC4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
Molecular Weight169.18
Pubchem Id951
Chembl IdCHEMBL432
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 35234
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT009621 5-hydroxytryptamine receptor 7 reviewed Htr7 1020 - - -
reviewed BXGT009621 5-hydroxytryptamine receptor 7 reviewed Htr7 >10000 - - -
reviewed BXGT009621 5-hydroxytryptamine receptor 7 reviewed Htr7 18 - - -
reviewed BXGT009621 5-hydroxytryptamine receptor 7 reviewed Htr7 1500 - - -
reviewed BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 >10000 - - -
reviewed BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 800 - - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 600 - - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a >10000 - - -
reviewed BXGT009621 5-hydroxytryptamine receptor 7 reviewed Htr7 900 - - -
reviewed BXGT019575 D(1A) dopamine receptor reviewed DRD1 820 - - -
reviewed BXGT019575 D(1A) dopamine receptor reviewed DRD1 200 - - -
reviewed BXGT008560 D(2) dopamine receptor reviewed DRD2 >10000 - - -
reviewed BXGT008560 D(2) dopamine receptor reviewed DRD2 5600 - - -
reviewed BXGT009486 5-hydroxytryptamine receptor 5A reviewed Htr5a >10000 - - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 100 - - -
reviewed BXGT008160 Alpha-1B adrenergic receptor reviewed Adra1b >10000 - - -
reviewed BXGT008382 Alpha-1A adrenergic receptor reviewed ADRA1A 9730 - - -
reviewed BXGT009272 5-hydroxytryptamine receptor 1B reviewed Htr1b >10000 - - -
reviewed BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 >10000 - - -
reviewed BXGT008708 D(1B) dopamine receptor reviewed G-protein coupled receptor DRD5 >10000 - - -
reviewed BXGT009565 Sodium-dependent serotonin transporter reviewed Slc6a4 1000 - - -
reviewed BXGT008936 Sodium-dependent dopamine transporter reviewed Slc6a3 >10000 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 3443 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 1442 - - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 90 - - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 26 - - -
reviewed BXGT005194 Alpha-2B adrenergic receptor (Fragment) reviewed ADRA2B 122 - - -
reviewed BXGT008472 5-hydroxytryptamine receptor 1A reviewed Htr1a >10000 - - -
reviewed BXGT008440 D(1A) dopamine receptor reviewed Drd1 >10000 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 >10000 - - -
reviewed BXGT009819 5-hydroxytryptamine receptor 5A reviewed Htr5a 1000 - - -
reviewed BXGT009820 5-hydroxytryptamine receptor 5B reviewed Htr5b 1000 - - -
reviewed BXGT008428 Alpha-1B adrenergic receptor reviewed ADRA1B 920 - - -
reviewed BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A 199.52 - - -
reviewed BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A 3981.07 - - -
reviewed BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A >10000 - - -
reviewed BXGT010360 Alpha-1A adrenergic receptor reviewed Adra1a 125.89 - - -
reviewed BXGT001606 Solute carrier family 22 member 1 reviewed SLC22A1 >10000 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 15.13 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 72.44 - - -
reviewed BXGT013955 Alpha-2A adrenergic receptor reviewed ADRA2A 933.25 - - -
reviewed BXGT005194 Alpha-2B adrenergic receptor (Fragment) reviewed ADRA2B 123.02 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 56.23 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 128.82 - - -
reviewed BXGT013955 Alpha-2A adrenergic receptor reviewed ADRA2A 1047.12 - - -
reviewed BXGT005194 Alpha-2B adrenergic receptor (Fragment) reviewed ADRA2B 28.18 - - -
reviewed BXGT008434 Alpha-2A adrenergic receptor reviewed ADRA2A 371 - - -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a 3190 - - -
reviewed BXGT013955 Alpha-2A adrenergic receptor reviewed ADRA2A 1094 - - -
reviewed BXGT009777 5-hydroxytryptamine receptor 7 reviewed G-protein coupled receptor HTR7 >10000 - - -
reviewed BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 8500 - - -
reviewed BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 >10000 - - -
reviewed BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 9800 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c >10000 - - -
reviewed BXGT009621 5-hydroxytryptamine receptor 7 reviewed Htr7 1000 - - -
reviewed BXGT021415 5-hydroxytryptamine receptor 6 reviewed Htr6 >10000 - - -
reviewed BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A 7500 - - -
reviewed BXGT008472 5-hydroxytryptamine receptor 1A reviewed Htr1a 545 - - -
reviewed BXGT009621 5-hydroxytryptamine receptor 7 reviewed Htr7 545 - - -
reviewed BXGT009531 5-hydroxytryptamine receptor 5B reviewed Htr5b >10000 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 0.5 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 1.8 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 3130 - - -
reviewed BXGT011367 D(2) dopamine receptor reviewed Drd2 2250 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 1995.26 - - -
reviewed BXGT012584 Alpha-2A adrenergic receptor reviewed Adra2a 1412.54 - - -
reviewed BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B 2754.23 - - -
reviewed BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C 1348.96 - - -
reviewed BXGT021937 Alpha-1A adrenergic receptor reviewed ADRA1A >10000 - - -
reviewed BXGT021937 Alpha-1A adrenergic receptor reviewed ADRA1A 6309.57 - - -
reviewed BXGT021937 Alpha-1A adrenergic receptor reviewed ADRA1A 5011.87 - - -
reviewed BXGT006837 5-hydroxytryptamine receptor 1A reviewed G-protein coupled receptor HTR1A >10000 - - -
reviewed BXGT006838 5-hydroxytryptamine receptor 2C reviewed Htr2c >10000 - - -
reviewed BXGT009819 5-hydroxytryptamine receptor 5A reviewed Htr5a >10000 - - -
reviewed BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 >10000 - - -
reviewed BXGT008434 Alpha-2A adrenergic receptor reviewed ADRA2A 5623.41 - - -
reviewed BXGT009565 Sodium-dependent serotonin transporter reviewed Slc6a4 >10000 - - -
reviewed BXGT008936 Sodium-dependent dopamine transporter reviewed Slc6a3 357 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 398.1072 - - -
reviewed BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B 331.1311 - - -
reviewed BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C 588.8437 - - -
reviewed BXGT008728 Alpha-2C adrenergic receptor reviewed Adra2c 45 - - -
reviewed BXGT005197 Alpha-2B adrenergic receptor (Fragment) reviewed ADRA2B 284 - - -
reviewed BXGT005197 Alpha-2B adrenergic receptor (Fragment) reviewed ADRA2B 57 - - -
reviewed BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A 996 - - -
reviewed BXGT008818 Alpha-2A adrenergic receptor reviewed Adra2a 1031 - - -
reviewed BXGT019728 Trace amine-associated receptor 1 reviewed G-protein coupled receptor TAAR1 >10000 - - -
reviewed BXGT009814 Alpha-1A adrenergic receptor reviewed G-protein coupled receptor ADRA1A 8709.64 - - -
reviewed BXGT009822 Alpha-1B adrenergic receptor reviewed G-protein coupled receptor ADRA1B 7585.78 - - -
reviewed BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D >10000 - - -
reviewed BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 3570 - - -
reviewed BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 4300 - - -
reviewed BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 3162.28 - - -
CHEMBL CHEMBL432
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 4610 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 7304 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 670 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 2993 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 14125 nM
P26255 BXGT009093 Beta-3 adrenergic receptor reviewed - Adrb3 EC50 '=' 800 nM
P10608 BXGT007586 Beta-2 adrenergic receptor reviewed - Adrb2 EC50 '=' 800 nM
P18090 BXGT008380 Beta-1 adrenergic receptor reviewed - Adrb1 EC50 '=' 800 nM
P07378 BXGT006616 Phosphoglycerate kinase, glycosomal reviewed - Potency - 4775 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 100000 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 15848 nM
P26255 BXGT009093 Beta-3 adrenergic receptor reviewed - Adrb3 EC50 '=' 5000 nM
P10608 BXGT007586 Beta-2 adrenergic receptor reviewed - Adrb2 EC50 '=' 5000 nM
P18090 BXGT008380 Beta-1 adrenergic receptor reviewed - Adrb1 EC50 '=' 5000 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a EC50 '=' 5000 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b EC50 '=' 5000 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c EC50 '=' 5000 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a EC50 '=' 5000 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d EC50 '=' 5000 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b EC50 '=' 5000 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 1158 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 23934 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 9466 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 79432 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 7519 nM
P22909 BXGT008818 Alpha-2A adrenergic receptor reviewed - Adra2a EC50 '=' 3000 nM
P19328 BXGT008473 Alpha-2B adrenergic receptor reviewed - Adra2b EC50 '=' 3000 nM
P22086 BXGT008728 Alpha-2C adrenergic receptor reviewed - Adra2c EC50 '=' 3000 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a EC50 '=' 3000 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d EC50 '=' 3000 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b EC50 '=' 3000 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00132 Scarlet bean Phaseolus coccineus Pulses
BXGF00141 Common pea Pisum sativum Pulses
BXGF00142 Purslane Portulaca oleracea Herbs and Spices
BXGF00175 Potato Solanum tuberosum Vegetables
BXGF00400 French plantain Musa X paradisiaca Fruits
BXGF00806 Alcoholic beverages Beverages
BXGF00811 Citrus Fruits
BXGF00823 Fruits Fruits
BXGF00824 Green vegetables Vegetables
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease