Showing entry for Activin receptor type-1B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009940
Protein NameActivin receptor type-1B
Uniport IdP36896
GeneACVR1B
Gene Id91
DomainActivin_recp; Pkinase; TGF_beta_GS
Pfam PF01064   PF00069   PF08515  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction
3. Environmental Information Processing 3.2 Signal transduction hsa04350 TGF-beta signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032924 activin receptor signaling pathway
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0007417 central nervous system development
Biological Process GO:0046545 development of primary female sexual characteristics
Biological Process GO:0097191 extrinsic apoptotic signaling pathway
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
Biological Process GO:0001942 hair follicle development
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0007399 nervous system development
Biological Process GO:0038092 nodal signaling pathway
Biological Process GO:0018107 peptidyl-threonine phosphorylation
Biological Process GO:0032927 positive regulation of activin receptor signaling pathway
Biological Process GO:0045648 positive regulation of erythrocyte differentiation
Biological Process GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:1901165 positive regulation of trophoblast cell migration
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0007165 signal transduction
Biological Process GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
molecular function GO:0048185 activin binding
molecular function GO:0016361 activin receptor activity, type I
molecular function GO:0005524 ATP binding
molecular function GO:0034711 inhibin binding
molecular function GO:0046872 metal ion binding
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0046332 SMAD binding
molecular function GO:0004675 transmembrane receptor protein serine/threonine kinase activity
molecular function GO:0031625 ubiquitin protein ligase binding
cellular component GO:0048179 activin receptor complex
cellular component GO:0009986 cell surface
cellular component GO:0005829 cytosol
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-1181150 Signaling by NODAL
R-HSA-1266738 Developmental Biology
R-HSA-1433617 Regulation of signaling by NODAL
R-HSA-1502540 Signaling by Activin
R-HSA-162582 Signal Transduction
R-HSA-9006936 Signaling by TGFB family members
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0017638 BXGD001132 Glioma Neoplasms
C0018021 BXGD001162 Goiter Endocrine System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0036631 BXGD002626 Seminoma Neoplasms
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0200633 BXGD004040 Neutrophil count (procedure)
C0200638 BXGD004043 Eosinophil count procedure
C0200641 BXGD004044 Blood basophil count (lab test)
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0278803 BXGD006593 Adenocarcinoma of small intestine Digestive System Diseases; Neoplasms
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0741276 BXGD010031 ATRIAL ENLARGEMENT
C0857490 BXGD011150 Granulocyte count
C1269955 BXGD012005 Tumor Cell Invasion
C1397307 BXGD012996 Cardiac fibrosis
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3548479 BXGD019120 response to bronchodilator
C4511687 BXGD023010 Pancreatic Intraductal Papillary Mucinous Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0012352 Chelerythrine 348.12
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein