Showing entry for E3 ubiquitin-protein ligase NEDD4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010553
Protein NameE3 ubiquitin-protein ligase NEDD4
Uniport IdP46934
GeneNEDD4
Gene Id4734
DomainHECT; WW
Pfam PF00632   PF00397  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04530 Tight junction
6. Human Diseases 6.9 Infectious diseases: Viral hsa05169 Epstein-Barr virus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0034644 cellular response to UV
Biological Process GO:0044111 development involved in symbiotic interaction
Biological Process GO:0042921 glucocorticoid receptor signaling pathway
Biological Process GO:0007041 lysosomal transport
Biological Process GO:2000650 negative regulation of sodium ion transmembrane transporter activity
Biological Process GO:0010766 negative regulation of sodium ion transport
Biological Process GO:0010768 negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
Biological Process GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
Biological Process GO:0007528 neuromuscular junction development
Biological Process GO:0031175 neuron projection development
Biological Process GO:0046824 positive regulation of nucleocytoplasmic transport
Biological Process GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:0045732 positive regulation of protein catabolic process
Biological Process GO:0050847 progesterone receptor signaling pathway
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0070534 protein K63-linked ubiquitination
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0006622 protein targeting to lysosome
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0032801 receptor catabolic process
Biological Process GO:0031623 receptor internalization
Biological Process GO:0048814 regulation of dendrite morphogenesis
Biological Process GO:0034765 regulation of ion transmembrane transport
Biological Process GO:0016241 regulation of macroautophagy
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:1901016 regulation of potassium ion transmembrane transporter activity
Biological Process GO:0050807 regulation of synapse organization
Biological Process GO:0051592 response to calcium ion
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
Biological Process GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Biological Process GO:0046755 viral budding
molecular function GO:0031698 beta-2 adrenergic receptor binding
molecular function GO:0019899 enzyme binding
molecular function GO:0050815 phosphoserine residue binding
molecular function GO:0050816 phosphothreonine residue binding
molecular function GO:0070064 proline-rich region binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0070063 RNA polymerase binding
molecular function GO:0019871 sodium channel inhibitor activity
molecular function GO:0043130 ubiquitin binding
molecular function GO:0061630 ubiquitin protein ligase activity
cellular component GO:0016327 apicolateral plasma membrane
cellular component GO:0005938 cell cortex
cellular component GO:0000785 chromatin
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0043197 dendritic spine
cellular component GO:0070062 extracellular exosome
cellular component GO:0005794 Golgi apparatus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0000151 ubiquitin ligase complex
Reactome
Pathway Id Pathway Name
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
R-HSA-1236394 Signaling by ERBB4
R-HSA-1253288 Downregulation of ERBB4 signaling
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-6807070 PTEN Regulation
R-HSA-8948747 Regulation of PTEN localization
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-913531 Interferon Signaling
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006309 BXGD000392 Brucellosis Infections
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0013312 BXGD000814 Dupuytren Contracture Neoplasms; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0014057 BXGD000880 Japanese Encephalitis Infections; Nervous System Diseases
C0014170 BXGD000902 Endometrial Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0014518 BXGD000921 Toxic Epidermal Necrolysis Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders; Stomatognathic Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0022548 BXGD001551 Keloid Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0023860 BXGD001708 Listeriosis Infections
C0025202 BXGD001832 melanoma Neoplasms
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026846 BXGD001939 Muscular Atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0034494 BXGD002481 Rabies (disorder) Infections
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0038325 BXGD002745 Stevens-Johnson Syndrome Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders; Stomatognathic Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0039101 BXGD002790 synovial sarcoma Neoplasms
C0039483 BXGD002813 Giant Cell Arteritis Skin and Connective Tissue Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0040420 BXGD002861 Tonometry
C0041296 BXGD002903 Tuberculosis Infections
C0042769 BXGD002999 Virus Diseases Infections
C0085423 BXGD003173 Gram-Negative Bacterial Infections Infections
C0085548 BXGD003183 Autosomal Recessive Polycystic Kidney Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0151514 BXGD003429 Atrophic condition of skin Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0221043 BXGD004377 Liddle Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0268436 BXGD005946 Pseudohypoaldosteronism, Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0270913 BXGD006130 Charcot-Marie-Tooth disease, Type 1C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0278660 BXGD006555 Adult Synovial Sarcoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279982 BXGD006702 Childhood Synovial Sarcoma Neoplasms
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0282687 BXGD006826 Hemorrhagic Fever, Ebola Infections
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0342649 BXGD007522 Vascular calcification Nutritional and Metabolic Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0740380 BXGD009983 Varicella zoster
C1269955 BXGD012005 Tumor Cell Invasion
C1274933 BXGD012051 Drug-Induced Stevens Johnson Syndrome Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders; Stomatognathic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1333762 BXGD012639 Gastric Cardia Adenocarcinoma
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1519680 BXGD013244 Tumor Immunity Pathological Conditions, Signs and Symptoms
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1861736 BXGD016072 SPINOCEREBELLAR ATAXIA 31 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931689 BXGD018049 Dystrophia myotonica 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3658301 BXGD019259 Mycoplasma-Induced Stevens-Johnson Syndrome Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders; Stomatognathic Diseases
C3658302 BXGD019260 Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders; Stomatognathic Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0003342 Guanidine 59.07
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein