Showing entry for Ras-related protein Rab-7a


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010835
Protein NameRas-related protein Rab-7a
Uniport IdP51149
GeneRAB7A
Gene Id7879
DomainRas
Pfam PF00071  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04137 Mitophagy - animal
4. Cellular Processes 4.1 Transport and catabolism hsa04140 Autophagy - animal
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05132 Salmonella infection
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05146 Amoebiasis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05152 Tuberculosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process GO:0000045 autophagosome assembly
Biological Process GO:0045022 early endosome to late endosome transport
Biological Process GO:0006897 endocytosis
Biological Process GO:0008333 endosome to lysosome transport
Biological Process GO:0007174 epidermal growth factor catabolic process
Biological Process GO:0016042 lipid catabolic process
Biological Process GO:0061724 lipophagy
Biological Process GO:1902586 multi-organism intercellular transport
Biological Process GO:1903542 negative regulation of exosomal secretion
Biological Process GO:1905366 negative regulation of intralumenal vesicle formation
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0090383 phagosome acidification
Biological Process GO:0090385 phagosome-lysosome fusion
Biological Process GO:0090382 phagosome maturation
Biological Process GO:1903543 positive regulation of exosomal secretion
Biological Process GO:0045732 positive regulation of protein catabolic process
Biological Process GO:0048524 positive regulation of viral process
Biological Process GO:0006622 protein targeting to lysosome
Biological Process GO:0022615 protein to membrane docking
Biological Process GO:0015031 protein transport
Biological Process GO:0042147 retrograde transport, endosome to Golgi
Biological Process GO:0019076 viral release from host cell
molecular function GO:0019003 GDP binding
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:1905394 retromer complex binding
cellular component GO:0000421 autophagosome membrane
cellular component GO:0005829 cytosol
cellular component GO:0010008 endosome membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0032419 extrinsic component of lysosome membrane
cellular component GO:0005770 late endosome
cellular component GO:0031902 late endosome membrane
cellular component GO:0005811 lipid droplet
cellular component GO:0005765 lysosomal membrane
cellular component GO:0005764 lysosome
cellular component GO:0033162 melanosome membrane
cellular component GO:0045335 phagocytic vesicle
cellular component GO:0030670 phagocytic vesicle membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0030667 secretory granule membrane
Reactome
Pathway Id Pathway Name
R-HSA-1280218 Adaptive Immune System
R-HSA-1643685 Disease
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-199991 Membrane Trafficking
R-HSA-2132295 MHC class II antigen presentation
R-HSA-392499 Metabolism of proteins
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5663205 Infectious disease
R-HSA-597592 Post-translational protein modification
R-HSA-6798695 Neutrophil degranulation
R-HSA-8854214 TBC/RABGAPs
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
R-HSA-9007101 Rab regulation of trafficking
R-HSA-9635486 Infection with Mycobacterium tuberculosis
R-HSA-9636383 Prevention of phagosomal-lysosomal fusion
R-HSA-9636569 Suppression of autophagy
R-HSA-9637687 Suppression of phagosomal maturation
R-HSA-9637690 Response of Mtb to phagocytosis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0007965 BXGD000508 Chediak-Higashi Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0008525 BXGD000554 Choroideremia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020071 BXGD001356 Hereditary Sensory Autonomic Neuropathy, Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020580 BXGD001435 Hypesthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022336 BXGD001535 Creutzfeldt-Jakob disease Infections; Nervous System Diseases; Mental Disorders
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024530 BXGD001783 Malaria Infections
C0025202 BXGD001832 melanoma Neoplasms
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026936 BXGD001950 Mycoplasma Infections Infections
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027888 BXGD002056 Hereditary Motor and Sensory Neuropathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027889 BXGD002057 Hereditary Sensory and Autonomic Neuropathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0034494 BXGD002481 Rabies (disorder) Infections
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0043208 BXGD003039 Wolman Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0085119 BXGD003127 Foot Ulcer Skin and Connective Tissue Diseases
C0151313 BXGD003413 Sensory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151468 BXGD003424 Thyroid Gland Follicular Adenoma Neoplasms; Endocrine System Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0158266 BXGD003878 Intervertebral Disc Degeneration Musculoskeletal Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221060 BXGD004384 Mobius Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Stomatognathic Diseases
C0231791 BXGD004522 Toeing-in
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0235025 BXGD004713 Peripheral motor neuropathy Nervous System Diseases
C0270914 BXGD006131 Hereditary Motor and Sensory-Neuropathy Type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270921 BXGD006133 Axonal neuropathy Nervous System Diseases
C0271694 BXGD006239 Familial partial lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0278134 BXGD006498 Absence of sensation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0340643 BXGD007357 Dissection of aorta Cardiovascular Diseases
C0346109 BXGD007779 Malignant Mesothelioma of Peritoneum Neoplasms; Respiratory Tract Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0427065 BXGD008604 Distal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0427149 BXGD008608 Gait, Drop Foot Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600327 BXGD009704 Toxic Shock Syndrome Pathological Conditions, Signs and Symptoms; Infections
C0699739 BXGD009861 Sensory Neuropathy, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1136179 BXGD011712 Hammer Toe Musculoskeletal Diseases
C1262048 BXGD011866 Glial scar
C1269955 BXGD012005 Tumor Cell Invasion
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1443892 BXGD013073 Chronic Q Fever Infections
C1833219 BXGD013902 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2B (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1833225 BXGD013904 Dystrophic toenail
C1838625 BXGD014327 Warburg Sjo Fledelius syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1848736 BXGD014970 Distal amyotrophy
C1855772 BXGD015543 Absent corpus callosum cataract immunodeficiency Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1858285 BXGD015781 Decreased number of peripheral myelinated nerve fibers
C1858729 BXGD015825 Decreased motor nerve conduction velocity
C1866141 BXGD016379 Foot dorsiflexor weakness
C1968790 BXGD016736 Axonal degeneration/regeneration
C2363741 BXGD017100 HIV-1 infection
C2936797 BXGD018139 Acid cholesteryl ester hydrolase deficiency, type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4025619 BXGD021698 Peripheral axonal atrophy
C4025740 BXGD021769 Autoamputation of foot Musculoskeletal Diseases
C4049342 BXGD021926 Foot osteomyelitis Infections; Musculoskeletal Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4316899 BXGD022710 Cystinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0048845 Guanosine Triphosphate 522.99
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein