Showing entry for 26S proteasome non-ATPase regulatory subunit 7


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010874
Protein Name26S proteasome non-ATPase regulatory subunit 7
Uniport IdP51665
GenePSMD7
Gene Id5713
DomainJAB; MitMem_reg
Pfam PF01398   PF13012  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa03050 Proteasome
6. Human Diseases 6.9 Infectious diseases: Viral hsa05169 Epstein-Barr virus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031145 anaphase-promoting complex-dependent catabolic process
Biological Process GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
Biological Process GO:0038095 Fc-epsilon receptor signaling pathway
Biological Process GO:0070498 interleukin-1-mediated signaling pathway
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0038061 NIK/NF-kappaB signaling
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0006521 regulation of cellular amino acid metabolic process
Biological Process GO:1902036 regulation of hematopoietic stem cell differentiation
Biological Process GO:1901990 regulation of mitotic cell cycle phase transition
Biological Process GO:0043488 regulation of mRNA stability
Biological Process GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
Biological Process GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0002223 stimulatory C-type lectin receptor signaling pathway
Biological Process GO:0050852 T cell receptor signaling pathway
Biological Process GO:0055085 transmembrane transport
Biological Process GO:0033209 tumor necrosis factor-mediated signaling pathway
Biological Process GO:0060071 Wnt signaling pathway, planar cell polarity pathway
molecular function GO:0070122 isopeptidase activity
molecular function GO:0042803 protein homodimerization activity
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0016020 membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0000502 proteasome complex
cellular component GO:0005838 proteasome regulatory particle
cellular component GO:0034774 secretory granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-109581 Apoptosis
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-1169091 Activation of NF-kappaB in B cells
R-HSA-1234174 Cellular response to hypoxia
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236975 Antigen processing-Cross presentation
R-HSA-1236975 Antigen processing-Cross presentation
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1266738 Developmental Biology
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1280218 Adaptive Immune System
R-HSA-1280218 Adaptive Immune System
R-HSA-1430728 Metabolism
R-HSA-157118 Signaling by NOTCH
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-162906 HIV Infection
R-HSA-162909 Host Interactions of HIV factors
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-169911 Regulation of Apoptosis
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
R-HSA-180534 Vpu mediated degradation of CD4
R-HSA-180585 Vif-mediated degradation of APOBEC3G
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21
R-HSA-195253 Degradation of beta-catenin by the destruction complex
R-HSA-195721 Signaling by WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-202403 TCR signaling
R-HSA-202424 Downstream TCR signaling
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation
R-HSA-212436 Generic Transcription Pathway
R-HSA-212436 Generic Transcription Pathway
R-HSA-2262752 Cellular responses to stress
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-HSA-350562 Regulation of ornithine decarboxylase (ODC)
R-HSA-351202 Metabolism of polyamines
R-HSA-376176 Signaling by ROBO receptors
R-HSA-382551 Transport of small molecules
R-HSA-382556 ABC-family proteins mediated transport
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-392499 Metabolism of proteins
R-HSA-4086400 PCP/CE pathway
R-HSA-422475 Axon guidance
R-HSA-446652 Interleukin-1 family signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-453276 Regulation of mitotic cell cycle
R-HSA-453279 Mitotic G1 phase and G1/S transition
R-HSA-4608870 Asymmetric localization of PCP proteins
R-HSA-4641257 Degradation of AXIN
R-HSA-4641258 Degradation of DVL
R-HSA-5357801 Programmed Cell Death
R-HSA-5358346 Hedgehog ligand biogenesis
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5358351 Signaling by Hedgehog
R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
R-HSA-5387390 Hh mutants abrogate ligand secretion
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5610780 Degradation of GLI1 by the proteasome
R-HSA-5610783 Degradation of GLI2 by the proteasome
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5619084 ABC transporter disorders
R-HSA-5619115 Disorders of transmembrane transporters
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5663205 Infectious disease
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5676590 NIK-->noncanonical NF-kB signaling
R-HSA-5678895 Defective CFTR causes cystic fibrosis
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-5688426 Deubiquitination
R-HSA-5689603 UCH proteinases
R-HSA-5689880 Ub-specific processing proteases
R-HSA-597592 Post-translational protein modification
R-HSA-6798695 Neutrophil degranulation
R-HSA-6807070 PTEN Regulation
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex
R-HSA-68867 Assembly of the pre-replicative complex
R-HSA-68882 Mitotic Anaphase
R-HSA-68886 M Phase
R-HSA-68949 Orc1 removal from chromatin
R-HSA-69002 DNA Replication Pre-Initiation
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69052 Switching of origins to a post-replicative state
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69206 G1/S Transition
R-HSA-69239 Synthesis of DNA
R-HSA-69242 S Phase
R-HSA-69275 G2/M Transition
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69306 DNA Replication
R-HSA-69481 G2/M Checkpoints
R-HSA-69541 Stabilization of p53
R-HSA-69563 p53-Dependent G1 DNA Damage Response
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint
R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-HSA-69610 p53-Independent DNA Damage Response
R-HSA-69613 p53-Independent G1/S DNA damage checkpoint
R-HSA-69615 G1/S DNA Damage Checkpoints
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-74160 Gene expression (Transcription)
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-HSA-8878159 Transcriptional regulation by RUNX3
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8939902 Regulation of RUNX2 expression and activity
R-HSA-8941858 Regulation of RUNX3 expression and activity
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-8951664 Neddylation
R-HSA-8953854 Metabolism of RNA
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-9013694 Signaling by NOTCH4
R-HSA-9020702 Interleukin-1 signaling
R-HSA-9604323 Negative regulation of NOTCH4 signaling
R-HSA-9607240 FLT3 Signaling
R-HSA-9675108 Nervous system development
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002448 BXGD000115 Ameloblastoma Neoplasms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006145 BXGD000376 Breast Diseases Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010414 BXGD000669 Infection by Cryptococcus neoformans Infections
C0010606 BXGD000677 Adenoid Cystic Carcinoma Neoplasms
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0018553 BXGD001203 Hamartoma Syndrome, Multiple Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C0019045 BXGD001269 Hemoglobinopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023281 BXGD001628 Leishmaniasis Infections; Skin and Connective Tissue Diseases
C0023290 BXGD001631 Leishmaniasis, Visceral Infections
C0023348 BXGD001636 Leprosy, Lepromatous Infections
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024530 BXGD001783 Malaria Infections
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026916 BXGD001947 Mycobacterium avium-intracellulare Infection Infections
C0026918 BXGD001948 Mycobacterium Infections Infections
C0026936 BXGD001950 Mycoplasma Infections Infections
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030920 BXGD002263 Peptic Ulcer Digestive System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0036117 BXGD002577 Salmonella infections Infections
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0039483 BXGD002813 Giant Cell Arteritis Skin and Connective Tissue Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0079745 BXGD003091 Lymphoma, Large-Cell, Follicular Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153687 BXGD003683 Secondary malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0155877 BXGD003830 Allergic asthma Respiratory Tract Diseases; Immune System Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0205697 BXGD004108 Carcinoma, Spindle-Cell Neoplasms
C0206526 BXGD004180 Tuberculosis, Multidrug-Resistant Infections
C0206623 BXGD004189 Adenosquamous carcinoma Neoplasms
C0206664 BXGD004226 Teratocarcinoma Neoplasms
C0206703 BXGD004253 Carcinoma, Giant Cell Neoplasms
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242647 BXGD005184 Mucosa-Associated Lymphoid Tissue Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0263361 BXGD005292 Psoriasis vulgaris Skin and Connective Tissue Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0334254 BXGD007010 Lymphoepithelial carcinoma Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0343752 BXGD007642 Acute HIV infection Infections; Immune System Diseases
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0406317 BXGD008334 Chronic small plaque psoriasis Skin and Connective Tissue Diseases
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0549523 BXGD009386 Oropharynx (excludes nasopharynx)
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0741899 BXGD010042 Poorly differentiated carcinoma
C0856825 BXGD011118 Acute GVH disease Immune System Diseases
C0867389 BXGD011300 Chronic graft-versus-host disease Immune System Diseases
C1266002 BXGD011929 Non-small cell carcinoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1334455 BXGD012711 Pulmonary Sclerosing Hemangioma Neoplasms; Respiratory Tract Diseases
C1367554 BXGD012885 Adamantinoma Neoplasms; Musculoskeletal Diseases
C1535939 BXGD013323 Pneumocystis jiroveci pneumonia Infections; Respiratory Tract Diseases
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2363741 BXGD017100 HIV-1 infection
C2747816 BXGD017577 Complicated malaria Infections
C3203547 BXGD018566 Axial spondyloarthritis Musculoskeletal Diseases
C3840565 BXGD019797 Autoimmune thyroid disease (AITD)
C4721532 BXGD023752 Lymphoma, Non-Hodgkin, Familial Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0030612 tetraethylene glycol 194.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein