Showing entry for Methionine--tRNA ligase, cytoplasmic


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011149
Protein NameMethionine--tRNA ligase, cytoplasmic
Uniport IdP56192
GeneMARS1
Gene Id4141
DomainGST_C; GST_N_5; tRNA-synt_1g; WHEP-TRS
Pfam PF00043   PF18485   PF09334   PF00458  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.6 Metabolism of other amino acids hsa00450 Selenocompound metabolism
2. Genetic Information Processing 2.2 Translation hsa00970 Aminoacyl-tRNA biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071364 cellular response to epidermal growth factor stimulus
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0036120 cellular response to platelet-derived growth factor stimulus
Biological Process GO:0009267 cellular response to starvation
Biological Process GO:0006431 methionyl-tRNA aminoacylation
Biological Process GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
Biological Process GO:0009303 rRNA transcription
Biological Process GO:0006418 tRNA aminoacylation for protein translation
molecular function GO:0005524 ATP binding
molecular function GO:0004825 methionine-tRNA ligase activity
molecular function GO:0000049 tRNA binding
cellular component GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0016020 membrane
cellular component GO:0005730 nucleolus
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-2408522 Selenoamino acid metabolism
R-HSA-379716 Cytosolic tRNA aminoacylation
R-HSA-379724 tRNA Aminoacylation
R-HSA-392499 Metabolism of proteins
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-72766 Translation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001122 BXGD000023 Acidosis Nutritional and Metabolic Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0009080 BXGD000580 Clubbed Fingers Musculoskeletal Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010200 BXGD000653 Coughing Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030779 BXGD002252 Pelger-Huet Anomaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0033844 BXGD002435 Pseudotumor Pathological Conditions, Signs and Symptoms
C0034050 BXGD002452 Pulmonary Alveolar Proteinosis Respiratory Tract Diseases
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0085426 BXGD003174 Gram-Positive Bacterial Infections Infections
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0149651 BXGD003342 Clubbing
C0162557 BXGD003956 Liver Failure, Acute Digestive System Diseases
C0206062 BXGD004148 Lung Diseases, Interstitial Respiratory Tract Diseases
C0232744 BXGD004561 Decreased liver function
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0238621 BXGD004947 Aminoaciduria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0239842 BXGD005001 Tremor of hands
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0427149 BXGD008608 Gait, Drop Foot Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1263857 BXGD011900 Peripheral axonal neuropathy Nervous System Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1619700 BXGD013459 RENAL ADYSPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1843013 BXGD014549 Alzheimer disease, familial, type 3 Nervous System Diseases; Mental Disorders
C1847584 BXGD014876 Distal sensory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1848701 BXGD014967 Elevated hepatic transaminase
C1854494 BXGD015409 Slow progression
C1855483 BXGD015501 Progressive spastic paraplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1857704 BXGD015741 Abnormal myelination
C1861403 BXGD016045 Variable expressivity
C1866141 BXGD016379 Foot dorsiflexor weakness
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C3809651 BXGD019601 INFANTILE LIVER FAILURE SYNDROME 2
C4084821 BXGD022107 CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2U
C4225400 BXGD022263 INTERSTITIAL LUNG AND LIVER DISEASE
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4749431 BXGD024058 Autosomal recessive spastic paraplegia type 70
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0006275 L-Methionine 149.21
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein