Showing entry for Spectrin beta chain, non-erythrocytic 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012567
Protein NameSpectrin beta chain, non-erythrocytic 1
Uniport IdQ01082
GeneSPTBN1
Gene Id6711
DomainCH; PH; Spectrin
Pfam PF00307   PF15410   PF00435  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051693 actin filament capping
Biological Process GO:0007411 axon guidance
Biological Process GO:0007182 common-partner SMAD protein phosphorylation
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0043001 Golgi to plasma membrane protein transport
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0071709 membrane assembly
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0007009 plasma membrane organization
Biological Process GO:0032743 positive regulation of interleukin-2 production
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:1903076 regulation of protein localization to plasma membrane
Biological Process GO:0060390 regulation of SMAD protein signal transduction
molecular function GO:0003779 actin binding
molecular function GO:0030506 ankyrin binding
molecular function GO:0045296 cadherin binding
molecular function GO:0005516 calmodulin binding
molecular function GO:0051020 GTPase binding
molecular function GO:0005543 phospholipid binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0003723 RNA binding
molecular function GO:0005200 structural constituent of cytoskeleton
cellular component GO:0030673 axolemma
cellular component GO:0032437 cuticular plate
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0031430 M band
cellular component GO:0005730 nucleolus
cellular component GO:0014069 postsynaptic density
cellular component GO:0008091 spectrin
cellular component GO:0014731 spectrin-associated cytoskeleton
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1500931 Cell-Cell communication
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-199977 ER to Golgi Anterograde Transport
R-HSA-199991 Membrane Trafficking
R-HSA-373753 Nephrin family interactions
R-HSA-373760 L1CAM interactions
R-HSA-373760 L1CAM interactions
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-392499 Metabolism of proteins
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-445095 Interaction between L1 and Ankyrins
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-597592 Post-translational protein modification
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-948021 Transport to the Golgi and subsequent modification
R-HSA-9607240 FLT3 Signaling
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004903 BXGD000293 Beckwith-Wiedemann Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0005283 BXGD000308 beta Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0005890 BXGD000345 Body Height
C0005938 BXGD000351 Bone Density
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0014772 BXGD000948 Red Blood Cell Count measurement
C0015625 BXGD001006 Fanconi Anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0017654 BXGD001136 Glomerular Filtration Rate
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023508 BXGD001675 White Blood Cell Count procedure
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0040420 BXGD002861 Tonometry
C0043094 BXGD003026 Weight Gain Pathological Conditions, Signs and Symptoms
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0154778 BXGD003742 Myopia, Degenerative Eye Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0279584 BXGD006641 Childhood B Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0341439 BXGD007408 Chronic liver disease Digestive System Diseases
C0393525 BXGD008081 Progressive cerebellar ataxia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0521170 BXGD009131 Osteoporotic Fractures Wounds and Injuries
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677936 BXGD009737 Refractory cancer Neoplasms
C0685938 BXGD009829 Malignant neoplasm of gastrointestinal tract Digestive System Diseases; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0752123 BXGD010671 Spinocerebellar Ataxia Type 5 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0876973 BXGD011322 Infectious Lung Disorder Infections; Respiratory Tract Diseases
C1292772 BXGD012232 Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative Neoplasms; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1333990 BXGD012670 Hereditary Nonpolyposis Colorectal Cancer Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms; Nutritional and Metabolic Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C3160718 BXGD018468 PARKINSON DISEASE, LATE-ONSET
C3469521 BXGD018910 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3495890 BXGD019009 Osteochondral defects
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4529962 BXGD023178 Fatty Liver Disease
C4551993 BXGD023469 Amyotrophic Lateral Sclerosis, Familial Nutritional and Metabolic Diseases; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein