Showing entry for Acetylcholine receptor subunit epsilon


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012789
Protein NameAcetylcholine receptor subunit epsilon
Uniport IdQ04844
GeneCHRNE
Gene Id1145
DomainNeur_chan_LBD; Neur_chan_memb
Pfam PF02931   PF02932  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0006936 muscle contraction
Biological Process GO:0050877 nervous system process
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0007165 signal transduction
Biological Process GO:0007271 synaptic transmission, cholinergic
molecular function GO:0022848 acetylcholine-gated cation-selective channel activity
molecular function GO:0015464 acetylcholine receptor activity
molecular function GO:0008324 cation transmembrane transporter activity
molecular function GO:0030594 neurotransmitter receptor activity
cellular component GO:0005892 acetylcholine-gated channel complex
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099060 integral component of postsynaptic specialization membrane
cellular component GO:0031594 neuromuscular junction
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-181431 Acetylcholine binding and downstream events
R-HSA-622323 Presynaptic nicotinic acetylcholine receptors
R-HSA-622327 Postsynaptic nicotinic acetylcholine receptors
R-HSA-629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003886 BXGD000238 Arthrogryposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0005129 BXGD000304 Bernard-Soulier Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0010520 BXGD000675 Cyanosis Pathological Conditions, Signs and Symptoms
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0012569 BXGD000777 Diplopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0013144 BXGD000800 Drowsiness Mental Disorders
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015469 BXGD000996 Facial paralysis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Stomatognathic Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019569 BXGD001337 Hirschsprung Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0024636 BXGD001793 Malocclusion Stomatognathic Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0026896 BXGD001946 Myasthenia Gravis Neoplasms; Immune System Diseases; Nervous System Diseases
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0032181 BXGD002332 Platelet Count measurement
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0040100 BXGD002840 Thymoma Neoplasms; Hemic and Lymphatic Diseases
C0040115 BXGD002841 Thymus Hyperplasia Hemic and Lymphatic Diseases
C0040420 BXGD002861 Tonometry
C0085619 BXGD003207 Orthopnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0200665 BXGD004045 Platelet mean volume determination (procedure)
C0231807 BXGD004524 Dyspnea on exertion Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0232466 BXGD004543 Feeding difficulties
C0234182 BXGD004631 Gowers sign
C0234860 BXGD004698 Weak cry
C0235659 BXGD004763 Reduced fetal movement Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0240479 BXGD005039 Neck muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0393934 BXGD008158 Slow channel syndrome Nervous System Diseases
C0399526 BXGD008251 Class III malocclusion Stomatognathic Diseases
C0427063 BXGD008602 Shoulder girdle weakness
C0476273 BXGD008986 Respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0476408 BXGD008994 Reduced vital capacity
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0541794 BXGD009262 Skeletal muscle atrophy
C0587246 BXGD009616 Muscle weakness of limb Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0596887 BXGD009648 mathematical ability
C0751401 BXGD010427 Ophthalmoparesis Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0751882 BXGD010626 Myasthenic Syndromes, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0947912 BXGD011497 Myasthenias Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1280798 BXGD012129 Von Willebrand disease, platelet type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1834536 BXGD013977 Weakness of the intrinsic hand muscles
C1836047 BXGD014074 Long face
C1837091 BXGD014196 MYASTHENIC SYNDROME, CONGENITAL, ASSOCIATED WITH ACETYLCHOLINE RECEPTOR DEFICIENCY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1837098 BXGD014198 Easy fatigability
C1837108 BXGD014199 Decreased muscle mass
C1837122 BXGD014200 Myasthenic Syndrome, Congenital, Fast-Channel Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1837142 BXGD014201 Poor suck
C1837658 BXGD014257 Gross motor development delay Mental Disorders
C1843637 BXGD014597 Neck flexor weakness
C1853949 BXGD015369 MYASTHENIA, FAMILIAL INFANTILE, 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1853950 BXGD015370 Generalized hypotonia due to defect at the neuromuscular junction
C1853952 BXGD015371 Decreased miniature endplate potentials
C1854301 BXGD015391 Motor delay Mental Disorders
C1854387 BXGD015396 Type 1 muscle fiber predominance
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1861403 BXGD016045 Variable expressivity
C1864580 BXGD016235 Type 2 muscle fiber atrophy
C1866934 BXGD016427 Reduced tendon reflexes Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2228039 BXGD016957 Ankle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C2230441 BXGD016958 Triceps weakness
C2267233 BXGD017017 Neonatal Hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2674608 BXGD017250 Feeding difficulties in infancy
C2751260 BXGD017694 Macrothrombocytopenia Hemic and Lymphatic Diseases
C2830004 BXGD017804 Somnolence Pathological Conditions, Signs and Symptoms
C2985280 BXGD018223 Blood Protein Measurement
C3277076 BXGD018700 BERNARD-SOULIER SYNDROME, TYPE A2, AUTOSOMAL DOMINANT
C3277226 BXGD018711 Restrictive ventilatory defect
C3278148 BXGD018728 BERNARD-SOULIER SYNDROME, TYPE A1
C3279725 BXGD018774 Hip flexor weakness
C3806462 BXGD019512 Apneic episodes precipitated by illness, fatigue, stress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C3806467 BXGD019513 Respiratory insufficiency due to muscle weakness Respiratory Tract Diseases
C3828530 BXGD019744 Platelet Component Distribution Width Measurement
C3839460 BXGD019773 Nonprogressive
C4015465 BXGD020208 Thoracic kyphoscoliosis
C4021726 BXGD020735 EMG: myopathic abnormalities Musculoskeletal Diseases; Nervous System Diseases
C4021728 BXGD020737 EMG: decremental response of compound muscle action potential to repetitive nerve stimulation
C4021753 BXGD020758 Abnormality of the immune system
C4022584 BXGD020925 Fatigable weakness of neck muscles
C4022587 BXGD020928 Fatigable weakness of respiratory muscles
C4023154 BXGD021126 Impaired ristocetin-induced platelet aggregation
C4024601 BXGD021334 Weakness of long finger extensor muscles
C4025615 BXGD021696 Decreased size of nerve terminals
C4025671 BXGD021722 Sudden episodic apnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C4073190 BXGD022064 Abnormality of masticatory muscle
C4082299 BXGD022088 Bulbar palsy Nervous System Diseases
C4084823 BXGD022108 MYASTHENIC SYNDROME, CONGENITAL, 1A, SLOW-CHANNEL
C4225369 BXGD022245 MYASTHENIC SYNDROME, CONGENITAL, 4B, FAST-CHANNEL
C4225405 BXGD022266 MYASTHENIC SYNDROME, CONGENITAL, 1B, FAST-CHANNEL
C4225413 BXGD022269 MYASTHENIC SYNDROME, CONGENITAL, 4A, SLOW-CHANNEL
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002796 Nicotine 162.23
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein