Showing entry for Unconventional myosin-VIIa


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013348
Protein NameUnconventional myosin-VIIa
Uniport IdQ13402
GeneMYO7A
Gene Id4647
DomainFERM_M; IQ; Myosin_head; MyTH4
Pfam PF00373   PF00612   PF00063   PF00784  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030048 actin filament-based movement
Biological Process GO:0007015 actin filament organization
Biological Process GO:0060088 auditory receptor cell stereocilium organization
Biological Process GO:0034613 cellular protein localization
Biological Process GO:0050957 equilibrioception
Biological Process GO:0042462 eye photoreceptor cell development
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0007040 lysosome organization
Biological Process GO:0042490 mechanoreceptor differentiation
Biological Process GO:0001845 phagolysosome assembly
Biological Process GO:0051904 pigment granule transport
Biological Process GO:0048563 post-embryonic animal organ morphogenesis
Biological Process GO:0007423 sensory organ development
Biological Process GO:0050953 sensory perception of light stimulus
Biological Process GO:0007605 sensory perception of sound
Biological Process GO:0030050 vesicle transport along actin filament
Biological Process GO:0007601 visual perception
molecular function GO:0030898 actin-dependent ATPase activity
molecular function GO:0051015 actin filament binding
molecular function GO:0043531 ADP binding
molecular function GO:0005524 ATP binding
molecular function GO:0005516 calmodulin binding
molecular function GO:0042802 identical protein binding
molecular function GO:0000146 microfilament motor activity
molecular function GO:0019904 protein domain specific binding
molecular function GO:0047485 protein N-terminus binding
molecular function GO:0030507 spectrin binding
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005938 cell cortex
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005765 lysosomal membrane
cellular component GO:0042470 melanosome
cellular component GO:0005902 microvillus
cellular component GO:0031477 myosin VII complex
cellular component GO:0032391 photoreceptor connecting cilium
cellular component GO:0001917 photoreceptor inner segment
cellular component GO:0001750 photoreceptor outer segment
cellular component GO:0032420 stereocilium
cellular component GO:0120044 stereocilium base
cellular component GO:0045202 synapse
cellular component GO:1990435 upper tip-link density
cellular component GO:0031982 vesicle
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-2187338 Visual phototransduction
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005890 BXGD000345 Body Height
C0011053 BXGD000694 Deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0018524 BXGD001200 Hallucinations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018979 BXGD001260 Hemianopsia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0024440 BXGD001774 Macular Edema, Cystoid Eye Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027092 BXGD001971 Myopia Eye Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036454 BXGD002616 Scotoma Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0042798 BXGD003003 Low Vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0152459 BXGD003600 Linear atrophy Pathological Conditions, Signs and Symptoms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0154860 BXGD003752 Hereditary retinal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0154920 BXGD003755 Pigmentary iris degeneration Eye Diseases; Skin and Connective Tissue Diseases
C0206586 BXGD004181 Endolymphatic Hydrops Otorhinolaryngologic Diseases
C0240340 BXGD005031 Microdontia (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0266589 BXGD005698 Congenital ear anomaly NOS (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Otorhinolaryngologic Diseases
C0271097 BXGD006163 Usher Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0271215 BXGD006175 Blindness, Legal Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0271514 BXGD006207 Low frequency deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0339527 BXGD007260 Leber Congenital Amaurosis Eye Diseases
C0339534 BXGD007262 Usher syndrome type 2 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0339543 BXGD007267 Epiretinal Membrane Eye Diseases
C0339789 BXGD007282 Congenital deafness Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Nervous System Diseases; Otorhinolaryngologic Diseases
C0395973 BXGD008176 Recessive sensorineural hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0422943 BXGD008465 Visual symptoms
C0452138 BXGD008831 Sensorineural hearing loss, bilateral Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476397 BXGD008991 Electroretinogram abnormal
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0557874 BXGD009444 Global developmental delay
C0575090 BXGD009513 Equilibration disorder Nervous System Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0752166 BXGD010684 Bardet-Biedl Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C0854723 BXGD011026 Retinal Dystrophies Eye Diseases
C0859886 BXGD011203 Inherited hearing loss
C1269955 BXGD012005 Tumor Cell Invasion
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1568247 BXGD013418 Usher Syndrome, Type I Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1568248 BXGD013419 Usher Syndrome, Type III Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1568249 BXGD013420 Usher Syndrome, Type II Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1832187 BXGD013809 Deafness, Autosomal Dominant 12 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1832425 BXGD013842 Deafness, Autosomal Dominant 9 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1832475 BXGD013849 Deafness, Autosomal Dominant 11 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1838701 BXGD014338 DEAFNESS, AUTOSOMAL RECESSIVE 2 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1843156 BXGD014561 Progressive sensorineural hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1848606 BXGD014950 Vestibular hypofunction
C1848638 BXGD014952 USHER SYNDROME, TYPE IB (disorder) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1848639 BXGD014953 USHER SYNDROME, TYPE IA, FORMERLY
C1848640 BXGD014954 USHER SYNDROME, TYPE I, FRENCH VARIETY, FORMERLY
C1848641 BXGD014955 Profound sensorineural hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1849265 BXGD015028 Overgrowth
C1852271 BXGD015268 Auditory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1854301 BXGD015391 Motor delay Mental Disorders
C1855465 BXGD015498 STARGARDT DISEASE 1 (disorder)
C1855685 BXGD015531 Undetectable electroretinogram
C1855925 BXGD015561 Hyperopia, High Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1865866 BXGD016345 Congenital sensorineural hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1866095 BXGD016372 Deafness, Autosomal Dominant 13 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1955603 BXGD016603 Deaf-Blind Disorders Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1955858 BXGD016609 Deaf-Blind Syndromes Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2732267 BXGD017551 Auditory neuropathy spectrum disorder Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C2931205 BXGD017977 Usher syndrome, type 1A Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C2931206 BXGD017978 Usher syndrome, type 1B Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C2931258 BXGD017991 Amaurosis congenita of Leber, type 1 Eye Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3279222 BXGD018751 Aplasia/Hypoplasia of the cerebellum
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665386 BXGD019284 Abnormal vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3668948 BXGD019321 Circling behavior
C3711374 BXGD019382 Nonsyndromic Deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887873 BXGD019922 Hearing Loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C4021800 BXGD020790 Abnormality of dental enamel
C4022757 BXGD020986 Moderate hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C4022758 BXGD020987 Mild hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C4023018 BXGD021068 Subcortical cerebral atrophy
C4023340 BXGD021157 Childhood onset sensorineural hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C4023551 BXGD021215 Abnormality of dental color
C4024656 BXGD021360 Absent vestibular function
C4025858 BXGD021832 Abnormal cochlea morphology
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4551583 BXGD023361 Cerebral cortical atrophy
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein