Showing entry for NAD(P) transhydrogenase, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013352
Protein NameNAD(P) transhydrogenase, mitochondrial
Uniport IdQ13423
GeneNNT
Gene Id23530
DomainAlaDh_PNT_C; AlaDh_PNT_N; PNTB; PNTB_4TM
Pfam PF01262   PF05222   PF02233   PF12769  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00760 Nicotinate and nicotinamide metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0045454 cell redox homeostasis
Biological Process GO:0098869 cellular oxidant detoxification
Biological Process GO:0006740 NADPH regeneration
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0032364 oxygen homeostasis
Biological Process GO:1903285 positive regulation of hydrogen peroxide catabolic process
Biological Process GO:0010918 positive regulation of mitochondrial membrane potential
Biological Process GO:1902600 proton transmembrane transport
Biological Process GO:0072593 reactive oxygen species metabolic process
Biological Process GO:0033273 response to vitamin
Biological Process GO:0006099 tricarboxylic acid cycle
molecular function GO:0003957 NAD(P)+ transhydrogenase (B-specific) activity
molecular function GO:0008746 NAD(P)+ transhydrogenase activity
molecular function GO:0051287 NAD binding
molecular function GO:0050661 NADP binding
cellular component GO:0016021 integral component of membrane
cellular component GO:0016020 membrane
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005746 mitochondrial respirasome
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
R-HSA-1430728 Metabolism
R-HSA-71403 Citric acid cycle (TCA cycle)
R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001403 BXGD000048 Addison Disease Immune System Diseases; Endocrine System Diseases
C0001623 BXGD000066 Adrenal gland hypofunction Endocrine System Diseases
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004509 BXGD000275 Azoospermia Male Urogenital Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010308 BXGD000661 Congenital Hypothyroidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0016522 BXGD001067 Foramen Ovale, Patent Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020461 BXGD001395 Hyperkalemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0020617 BXGD001446 Hypoglycemic coma Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0020625 BXGD001451 Hyponatremia Nutritional and Metabolic Diseases
C0020649 BXGD001459 Hypotension Cardiovascular Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0034013 BXGD002450 Precocious Puberty Endocrine System Diseases
C0034372 BXGD002480 Quadriplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0149521 BXGD003328 Pancreatitis, Chronic Digestive System Diseases
C0149871 BXGD003375 Deep Vein Thrombosis Cardiovascular Diseases
C0175701 BXGD004007 Aarskog syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0241240 BXGD005089 Tall stature
C0262655 BXGD005264 Recurrent urinary tract infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0271713 BXGD006247 Ketotic hypoglycemia Nutritional and Metabolic Diseases
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0342482 BXGD007486 X-linked Adrenal Hypoplasia Endocrine System Diseases
C0344724 BXGD007701 Ostium secundum atrial septal defect Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0405580 BXGD008325 Adrenal cortical hypofunction Endocrine System Diseases
C0518656 BXGD009071 Chronic fatigue Pathological Conditions, Signs and Symptoms
C0524909 BXGD009247 Hepatitis B, Chronic Digestive System Diseases; Infections
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0857899 BXGD011166 Decreased circulating aldosterone level Immune System Diseases; Endocrine System Diseases
C0877056 BXGD011334 Hypoglycemic seizures Nutritional and Metabolic Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1836623 BXGD014139 Decreased circulating cortisol level Immune System Diseases; Endocrine System Diseases
C1846347 BXGD014802 Renal salt wasting
C1960469 BXGD016664 Left ventricular noncompaction Cardiovascular Diseases
C3502131 BXGD019041 Adrenal Insufficiency, Congenital Endocrine System Diseases
C3548479 BXGD019120 response to bronchodilator
C3553587 BXGD019178 GLUCOCORTICOID DEFICIENCY 4 WITH OR WITHOUT MINERALOCORTICOID DEFICIENCY
C3671887 BXGD019330 Hypernatriuria
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3808022 BXGD019536 Episodic abdominal pain Pathological Conditions, Signs and Symptoms
C3887896 BXGD019925 Primary Adrenal Insufficiency
C4021133 BXGD020563 Left ventricular noncompaction cardiomyopathy Pathological Conditions, Signs and Symptoms
C4022011 BXGD020867 Leydig cell neoplasia Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C4023574 BXGD021219 Abnormality of circulating adrenocorticotropin level
C4024878 BXGD021453 Generalized hyperpigmentation Skin and Connective Tissue Diseases
C4049650 BXGD021946 Familial Glucocorticoid Deficiency Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Endocrine System Diseases
C4054695 BXGD021986 Familial glucocorticoid deficiency
C4310878 BXGD022680 GLUCOCORTICOID DEFICIENCY 4 WITH MINERALOCORTICOID DEFICIENCY
C4476786 BXGD022868 Testicular adrenal rest tumor Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C4476955 BXGD022895 Impaired cortisol response to insulin stimulation test
C4531272 BXGD023211 Decreased circulating dehydroepiandrosterone level
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein