Showing entry for Inositol 1,4,5-trisphosphate receptor type 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013486
Protein NameInositol 1,4,5-trisphosphate receptor type 3
Uniport IdQ14573
GeneITPR3
Gene Id3710
DomainIns145_P3_rec; Ion_trans; MIR; RIH_assoc; RYDR_ITPR
Pfam PF08709   PF00520   PF02815   PF08454   PF01365  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04070 Phosphatidylinositol signaling system
4. Cellular Processes 4.2 Cell growth and death hsa04114 Oocyte meiosis
4. Cellular Processes 4.2 Cell growth and death hsa04210 Apoptosis
4. Cellular Processes 4.2 Cell growth and death hsa04218 Cellular senescence
5. Organismal Systems 5.3 Circulatory system hsa04270 Vascular smooth muscle contraction
3. Environmental Information Processing 3.2 Signal transduction hsa04371 Apelin signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04540 Gap junction
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04625 C-type lectin receptor signaling pathway
5. Organismal Systems 5.10 Environmental adaptation hsa04713 Circadian entrainment
5. Organismal Systems 5.6 Nervous system hsa04720 Long-term potentiation
5. Organismal Systems 5.6 Nervous system hsa04723 Retrograde endocannabinoid signaling
5. Organismal Systems 5.6 Nervous system hsa04724 Glutamatergic synapse
5. Organismal Systems 5.6 Nervous system hsa04725 Cholinergic synapse
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
5. Organismal Systems 5.6 Nervous system hsa04728 Dopaminergic synapse
5. Organismal Systems 5.6 Nervous system hsa04730 Long-term depression
5. Organismal Systems 5.7 Sensory system hsa04742 Taste transduction
5. Organismal Systems 5.7 Sensory system hsa04750 Inflammatory mediator regulation of TRP channels
5. Organismal Systems 5.2 Endocrine system hsa04911 Insulin secretion
5. Organismal Systems 5.2 Endocrine system hsa04912 GnRH signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04918 Thyroid hormone synthesis
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04922 Glucagon signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04924 Renin secretion
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
5. Organismal Systems 5.2 Endocrine system hsa04927 Cortisol synthesis and secretion
5. Organismal Systems 5.2 Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
5. Organismal Systems 5.4 Digestive system hsa04970 Salivary secretion
5. Organismal Systems 5.4 Digestive system hsa04971 Gastric acid secretion
5. Organismal Systems 5.4 Digestive system hsa04972 Pancreatic secretion
6. Human Diseases 6.4 Neurodegenerative diseases hsa05010 Alzheimer disease
6. Human Diseases 6.9 Infectious diseases: Viral hsa05163 Human cytomegalovirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05167 Kaposi sarcoma-associated herpesvirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05170 Human immunodeficiency virus 1 infection
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0060402 calcium ion transport into cytosol
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0060291 long-term synaptic potentiation
Biological Process GO:0007613 memory
Biological Process GO:0030168 platelet activation
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:1903779 regulation of cardiac conduction
Biological Process GO:0050796 regulation of insulin secretion
Biological Process GO:0051209 release of sequestered calcium ion into cytosol
Biological Process GO:0051592 response to calcium ion
Biological Process GO:0050913 sensory perception of bitter taste
Biological Process GO:0050916 sensory perception of sweet taste
Biological Process GO:0050917 sensory perception of umami taste
molecular function GO:0005509 calcium ion binding
molecular function GO:0015278 calcium-release channel activity
molecular function GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding
molecular function GO:0070679 inositol 1,4,5 trisphosphate binding
molecular function GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
molecular function GO:0000822 inositol hexakisphosphate binding
molecular function GO:0035091 phosphatidylinositol binding
cellular component GO:0045177 apical part of cell
cellular component GO:0005903 brush border
cellular component GO:0005737 cytoplasm
cellular component GO:0030659 cytoplasmic vesicle membrane
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0016020 membrane
cellular component GO:0043209 myelin sheath
cellular component GO:0043025 neuronal cell body
cellular component GO:0005640 nuclear outer membrane
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0031095 platelet dense tubular network membrane
cellular component GO:0043235 receptor complex
cellular component GO:0016529 sarcoplasmic reticulum
cellular component GO:0030667 secretory granule membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-111885 Opioid Signalling
R-HSA-112040 G-protein mediated events
R-HSA-112043 PLC beta mediated events
R-HSA-114508 Effects of PIP2 hydrolysis
R-HSA-1280218 Adaptive Immune System
R-HSA-1280218 Adaptive Immune System
R-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-1489509 DAG and IP3 signaling
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-163685 Integration of energy metabolism
R-HSA-163685 Integration of energy metabolism
R-HSA-1643685 Disease
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-194138 Signaling by VEGF
R-HSA-195721 Signaling by WNT
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-388396 GPCR downstream signalling
R-HSA-388396 GPCR downstream signalling
R-HSA-397014 Muscle contraction
R-HSA-397014 Muscle contraction
R-HSA-4086398 Ca2+ pathway
R-HSA-416476 G alpha (q) signalling events
R-HSA-418346 Platelet homeostasis
R-HSA-418360 Platelet calcium homeostasis
R-HSA-418594 G alpha (i) signalling events
R-HSA-422356 Regulation of insulin secretion
R-HSA-422356 Regulation of insulin secretion
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-5576891 Cardiac conduction
R-HSA-5576891 Cardiac conduction
R-HSA-5578775 Ion homeostasis
R-HSA-5578775 Ion homeostasis
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-5663205 Infectious disease
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9658195 Leishmania infection
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664323 FCGR3A-mediated IL10 synthesis
R-HSA-9664433 Leishmania parasite growth and survival
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001197 BXGD000031 Acrodermatitis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004368 BXGD000271 Autoimmune state
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010051 BXGD000646 Coronary Aneurysm Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013264 BXGD000808 Muscular Dystrophy, Duchenne Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019187 BXGD001296 Hepatitis, Alcoholic Digestive System Diseases; Chemically-Induced Disorders
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020505 BXGD001412 Hyperphagia Pathological Conditions, Signs and Symptoms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022638 BXGD001567 Ketosis Nutritional and Metabolic Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026691 BXGD001917 Mucocutaneous Lymph Node Syndrome Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026850 BXGD001942 Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032617 BXGD002367 Polyuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085602 BXGD003199 Polydipsia Pathological Conditions, Signs and Symptoms
C0152459 BXGD003600 Linear atrophy Pathological Conditions, Signs and Symptoms
C0205734 BXGD004115 Diabetes, Autoimmune Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220656 BXGD004312 Malignant ascites Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0239816 BXGD004997 Hand eczema Skin and Connective Tissue Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0263372 BXGD005294 Gianotti-Crosti Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0276496 BXGD006426 Familial Alzheimer Disease (FAD) Nervous System Diseases; Mental Disorders
C0279671 BXGD006677 Cervical Squamous Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0341439 BXGD007408 Chronic liver disease Digestive System Diseases
C0342302 BXGD007458 Brittle diabetes Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0489786 BXGD009018 Height
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0855197 BXGD011079 Malignant Testicular Germ Cell Tumor Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0878773 BXGD011391 Overactive Bladder Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1527304 BXGD013266 Allergic Reaction Immune System Diseases
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1842937 BXGD014546 AURAL ATRESIA, CONGENITAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1860707 BXGD015993 TUBEROUS SCLEROSIS 2 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2919194 BXGD017869 Sporadic olivopontocerebellar atrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C3837958 BXGD019756 Diabetes Mellitus, Ketosis-Prone Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4087504 BXGD022156 Peritoneal dissemination
C4290046 BXGD022507 trachomatis
C4551693 BXGD023395 Wolfram Syndrome 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Male Urogenital Diseases; Nervous System Diseases; Endocrine System Diseases; Otorhinolaryngologic Diseases
C4552000 BXGD023473 Episodic Kinesigenic Dyskinesia 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4554117 BXGD023561 Diabetes Mellitus, Sudden-Onset Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C4703616 BXGD023663 Decreased level of 1,5 anhydroglucitol in serum
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001502 Caffeine 194.19
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein