Showing entry for Chromodomain-helicase-DNA-binding protein 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013509
Protein NameChromodomain-helicase-DNA-binding protein 4
Uniport IdQ14839
GeneCHD4
Gene Id1108
DomainCHDCT2; CHDNT; Chromo; DUF1086; DUF1087; Helicase_C; PHD; SNF2_N
Pfam PF08074   PF08073   PF00385   PF06461   PF06465   PF00271   PF00628   PF00176  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0043044 ATP-dependent chromatin remodeling
Biological Process GO:1901796 regulation of signal transduction by p53 class mediator
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
molecular function GO:0005524 ATP binding
molecular function GO:0003677 DNA binding
molecular function GO:0003678 DNA helicase activity
molecular function GO:0042826 histone deacetylase binding
molecular function GO:0001103 RNA polymerase II repressing transcription factor binding
molecular function GO:0008270 zinc ion binding
cellular component GO:0005813 centrosome
cellular component GO:0005737 cytoplasm
cellular component GO:0016020 membrane
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0016581 NuRD complex
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-166520 Signaling by NTRKs
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-198725 Nuclear Events (kinase and transcription factor activation)
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-3214815 HDACs deacetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-4839726 Chromatin organization
R-HSA-5250913 Positive epigenetic regulation of rRNA expression
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-5663205 Infectious disease
R-HSA-6804758 Regulation of TP53 Activity through Acetylation
R-HSA-6807070 PTEN Regulation
R-HSA-6807070 PTEN Regulation
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-73854 RNA Polymerase I Promoter Clearance
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73864 RNA Polymerase I Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-74160 Gene expression (Transcription)
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9031628 NGF-stimulated transcription
R-HSA-9679191 Potential therapeutics for SARS
R-HSA-9679506 SARS-CoV Infections
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0003803 BXGD000220 Arnold Chiari Malformation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0004106 BXGD000254 Astigmatism Eye Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009782 BXGD000631 Connective Tissue Diseases Skin and Connective Tissue Diseases
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014170 BXGD000902 Endometrial Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0014772 BXGD000948 Red Blood Cell Count measurement
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0039685 BXGD002825 Tetralogy of Fallot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0042580 BXGD002992 Vesico-Ureteral Reflux Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085996 BXGD003260 Child Development Deviations Mental Disorders
C0085997 BXGD003261 Child Development Disorders, Specific Mental Disorders
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206655 BXGD004218 Alveolar rhabdomyosarcoma Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0239234 BXGD004974 Low set ears
C0264611 BXGD005403 Apraxia of Phonation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0265535 BXGD005544 Trigonocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266362 BXGD005657 Ambiguous Genitalia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0278622 BXGD006551 Adult Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279613 BXGD006651 Childhood Alveolar Rhabdomyosarcoma Neoplasms
C0279987 BXGD006706 Childhood Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0349588 BXGD007933 Short stature
C0423109 BXGD008470 Upward slant of palpebral fissure
C0423112 BXGD008472 Short palpebral fissure
C0426886 BXGD008594 Tapering fingers (finding)
C0427460 BXGD008616 Red cell distribution width determination
C0431124 BXGD008663 Cellular Schwannoma Neoplasms
C0432072 BXGD008718 Dysmorphic features
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0678230 BXGD009750 Congenital Epicanthus
C0679401 BXGD009770 Vascular rupture Cardiovascular Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0751356 BXGD010406 Idiopathic Inflammatory Myopathies Musculoskeletal Diseases; Nervous System Diseases
C0751690 BXGD010553 Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1292769 BXGD012230 Precursor B-cell lymphoblastic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1387005 BXGD012953 Penis agenesis Male Urogenital Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1836150 BXGD014082 Gait imbalance
C1836184 BXGD014088 Short femoral neck
C1837485 BXGD014239 Flat acetabular roof
C1838705 BXGD014341 Anteriorly placed anus
C1845447 BXGD014747 Cupped ears (finding)
C1845847 BXGD014760 Coarse facial features Pathological Conditions, Signs and Symptoms
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2919142 BXGD017867 Short Stature, CTCAE
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3278923 BXGD018748 Dilated ventricles (finding)
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3888194 BXGD019955 MIXED LINEAGE LEUKEMIA
C4021790 BXGD020782 Abnormality of the skeletal system
C4310688 BXGD022624 SIFRIM-HITZ-WEISS SYNDROME
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C4727892 BXGD023876 Gatad2b associated neurodevelopmental disorder Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein