Showing entry for Precursor B-cell lymphoblastic leukemia


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD012230
Disease NamePrecursor B-cell lymphoblastic leukemia
Disease CUI IdC1292769
MeSH Codes C04   C20   C15  
Disease Class NameNeoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00512 BXGT003933 B-cell CLL/lymphoma 9 protein 607 reviewed
O14733 BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 5609 reviewed Kinase
O14744 BXGT004089 Protein arginine N-methyltransferase 5 10419 reviewed Epigenetic regulator
O14786 BXGT004099 Neuropilin-1 8829 reviewed
O15244 BXGT004140 Solute carrier family 22 member 2 6582 reviewed Transporter
O15350 BXGT004154 Tumor protein p73 7161 reviewed Transcription factor
O15379 BXGT004159 Histone deacetylase 3 8841 reviewed Epigenetic regulator
O15439 BXGT004169 Multidrug resistance-associated protein 4 10257 reviewed Transporter
O43521 BXGT004598 Bcl-2-like protein 11 10018 reviewed
O60260 BXGT004864 E3 ubiquitin-protein ligase parkin 5071 reviewed Enzyme
O60674 BXGT004892 Tyrosine-protein kinase JAK2 3717 reviewed Kinase
O60858 BXGT004903 E3 ubiquitin-protein ligase TRIM13 10206 reviewed
O75365 BXGT005115 Protein tyrosine phosphatase type IVA 3 11156 reviewed
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 8856 reviewed Nuclear receptor
O75643 BXGT005142 U5 small nuclear ribonucleoprotein 200 kDa helicase 23020 reviewed
P00374 BXGT005520 Dihydrofolate reductase 1719 reviewed Enzyme
P00519 BXGT005570 Tyrosine-protein kinase ABL1 25 reviewed Kinase
P00750 BXGT005642 Tissue-type plasminogen activator 5327 reviewed Enzyme
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P01024 BXGT005719 Complement C3 718 reviewed Enzyme modulator
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01270 BXGT005746 Parathyroid hormone 5741 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01589 BXGT005773 Interleukin-2 receptor subunit alpha 3559 reviewed Receptor
P01591 BXGT005774 Immunoglobulin J chain 3512 reviewed
P01920 BXGT005817 HLA class II histocompatibility antigen, DQ beta 1 chain 3119 reviewed Immune response
P02545 BXGT005889 Prelamin-A/C 4000 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02786 BXGT005961 Transferrin receptor protein 1 7037 reviewed Enzyme
P03950 BXGT006116 Angiogenin 283 reviewed
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04150 BXGT006154 Glucocorticoid receptor 2908 reviewed Nuclear receptor
P04440 BXGT006216 HLA class II histocompatibility antigen, DP beta 1 chain 3115 reviewed Immune response
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04798 BXGT006265 Cytochrome P450 1A1 1543 reviewed Enzyme
P05107 BXGT006316 Integrin beta-2 3689 reviewed Receptor
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05164 BXGT006333 Myeloperoxidase 4353 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05362 BXGT006350 Intercellular adhesion molecule 1 3383 reviewed
P06213 BXGT006425 Insulin receptor 3643 reviewed Kinase
P06734 BXGT006491 Low affinity immunoglobulin epsilon Fc receptor 2208 reviewed Receptor
P07333 BXGT006602 Macrophage colony-stimulating factor 1 receptor 1436 reviewed Kinase
P07339 BXGT006604 Cathepsin D 1509 reviewed Enzyme
P07355 BXGT006609 Annexin A2 302 reviewed
P07900 BXGT006696 Heat shock protein HSP 90-alpha 3320 reviewed Chaperone
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08473 BXGT006773 Neprilysin 4311 reviewed Enzyme
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C 5788 reviewed Enzyme
P08700 BXGT006816 Interleukin-3 3562 reviewed
P09429 BXGT006889 High mobility group protein B1 3146 reviewed Nucleic acid binding
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P09619 BXGT006911 Platelet-derived growth factor receptor beta 5159 reviewed Kinase
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P09917 BXGT006941 Arachidonate 5-lipoxygenase 240 reviewed Enzyme
P09960 BXGT006952 Leukotriene A-4 hydrolase 4048 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10599 BXGT007583 Thioredoxin 7295 reviewed
P10644 BXGT007597 cAMP-dependent protein kinase type I-alpha regulatory subunit 5573 reviewed
P10747 BXGT007609 T-cell-specific surface glycoprotein CD28 940 reviewed
P11215 BXGT007672 Integrin alpha-M 3684 reviewed
P11226 BXGT007675 Mannose-binding protein C 4153 reviewed Receptor
P11274 BXGT007681 Breakpoint cluster region protein 613 reviewed Enzyme modulator
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 5292 reviewed Kinase
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P11802 BXGT007750 Cyclin-dependent kinase 4 1019 reviewed Kinase
P11912 BXGT007758 B-cell antigen receptor complex-associated protein alpha chain 973 reviewed Receptor
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P12931 BXGT007859 Proto-oncogene tyrosine-protein kinase Src 6714 reviewed Kinase
P13569 BXGT007923 Cystic fibrosis transmembrane conductance regulator 1080 reviewed Ion channel
P15144 BXGT008087 Aminopeptidase N 290 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15814 BXGT008159 Immunoglobulin lambda-like polypeptide 1 3543 reviewed
P16070 BXGT008186 CD44 antigen 960 reviewed
P16234 BXGT008209 Platelet-derived growth factor receptor alpha 5156 reviewed Kinase
P16871 BXGT008269 Interleukin-7 receptor subunit alpha 3575 reviewed Receptor
P17931 BXGT008356 Galectin-3 3958 reviewed Signaling
P19429 BXGT008479 Troponin I, cardiac muscle 7137 reviewed Cellular structure
P19438 BXGT008480 Tumor necrosis factor receptor superfamily member 1A 7132 reviewed
P19544 BXGT008494 Wilms tumor protein 7490 reviewed Nucleic acid binding
P20273 BXGT008557 B-cell receptor CD22 933 reviewed
P21589 BXGT008669 5'-nucleotidase 4907 reviewed Enzyme
P22083 BXGT008727 Alpha-(1,3)-fucosyltransferase 4 2526 reviewed Enzyme
P22607 BXGT008784 Fibroblast growth factor receptor 3 2261 reviewed Kinase
P23141 BXGT008830 Liver carboxylesterase 1 1066 reviewed Enzyme
P23246 BXGT008840 Splicing factor, proline- and glutamine-rich 6421 reviewed Nucleic acid binding
P24941 BXGT009002 Cyclin-dependent kinase 2 1017 reviewed Kinase
P25103 BXGT009020 Substance-P receptor 6869 reviewed G-protein coupled receptor
P25116 BXGT009025 Proteinase-activated receptor 1 2149 reviewed G-protein coupled receptor
P25791 BXGT009072 Rhombotin-2 4005 reviewed
P26951 BXGT009147 Interleukin-3 receptor subunit alpha 3563 reviewed Signaling
P27797 BXGT009206 Calreticulin 811 reviewed Calcium-binding protein
P28072 BXGT009231 Proteasome subunit beta type-6 5694 reviewed
P28907 BXGT009301 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 952 reviewed Enzyme
P30530 BXGT009431 Tyrosine-protein kinase receptor UFO 558 reviewed Kinase
P30679 BXGT009457 Guanine nucleotide-binding protein subunit alpha-15 2769 reviewed Enzyme modulator
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P31260 BXGT009519 Homeobox protein Hox-A10 3206 reviewed
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P31785 BXGT009577 Cytokine receptor common subunit gamma 3561 reviewed Signaling
P32302 BXGT009619 C-X-C chemokine receptor type 5 643 reviewed G-protein coupled receptor
P33681 BXGT009739 T-lymphocyte activation antigen CD80 941 reviewed
P35610 BXGT009855 Sterol O-acyltransferase 1 6646 reviewed Enzyme
P36888 BXGT009938 Receptor-type tyrosine-protein kinase FLT3 2322 reviewed Kinase
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P40199 BXGT010166 Carcinoembryonic antigen-related cell adhesion molecule 6 4680 reviewed
P40933 BXGT010209 Interleukin-15 3600 reviewed
P41180 BXGT010230 Extracellular calcium-sensing receptor 846 reviewed G-protein coupled receptor
P41182 BXGT010231 B-cell lymphoma 6 protein 604 reviewed
P41212 BXGT010235 Transcription factor ETV6 2120 reviewed Transcription factor
P41440 BXGT010261 Folate transporter 1 6573 reviewed Transporter
P42261 BXGT010293 Glutamate receptor 1 2890 reviewed Ion channel
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43403 BXGT010385 Tyrosine-protein kinase ZAP-70 7535 reviewed Kinase
P43405 BXGT010386 Tyrosine-protein kinase SYK 6850 reviewed Kinase
P43490 BXGT010395 Nicotinamide phosphoribosyltransferase 10135 reviewed Signaling
P45381 BXGT010460 Aspartoacylase 443 reviewed
P46527 BXGT010525 Cyclin-dependent kinase inhibitor 1B 1027 reviewed
P47712 BXGT010577 Cytosolic phospholipase A2 5321 reviewed Enzyme
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48426 BXGT010630 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 5305 reviewed Kinase
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49768 BXGT010740 Presenilin-1 5663 reviewed Enzyme
P49789 BXGT010742 Bis(5'-adenosyl)-triphosphatase 2272 reviewed
P49917 BXGT010765 DNA ligase 4 3981 reviewed
P51148 BXGT010834 Ras-related protein Rab-5C 5878 reviewed
P51684 BXGT010880 C-C chemokine receptor type 6 1235 reviewed G-protein coupled receptor
P51692 BXGT010885 Signal transducer and activator of transcription 5B 6777 reviewed Nucleic acid binding
P52333 BXGT010928 Tyrosine-protein kinase JAK3 3718 reviewed Kinase
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 5347 reviewed Kinase
P54132 BXGT011032 Bloom syndrome protein 641 reviewed
P55072 BXGT011103 Transitional endoplasmic reticulum ATPase 7415 reviewed
P55157 BXGT011108 Microsomal triglyceride transfer protein large subunit 4547 reviewed Transporter
P55899 BXGT011131 IgG receptor FcRn large subunit p51 2217 reviewed
P55957 BXGT011137 BH3-interacting domain death agonist 637 reviewed
P56524 BXGT011176 Histone deacetylase 4 9759 reviewed Epigenetic regulator
P60033 BXGT011286 CD81 antigen 975 reviewed
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60568 BXGT011315 Interleukin-2 3558 reviewed
P60880 BXGT011335 Synaptosomal-associated protein 25 6616 reviewed Transporter
P61626 BXGT011382 Lysozyme C 4069 reviewed
P62834 BXGT011464 Ras-related protein Rap-1A 5906 reviewed Enzyme modulator
P78310 BXGT011830 Coxsackievirus and adenovirus receptor 1525 reviewed
P78344 BXGT011835 Eukaryotic translation initiation factor 4 gamma 2 1982 reviewed Nucleic acid binding
P78417 BXGT011843 Glutathione S-transferase omega-1 9446 reviewed
P80188 BXGT011882 Neutrophil gelatinase-associated lipocalin 3934 reviewed Enzyme
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 4088 reviewed Transcription factor
Q00534 BXGT012533 Cyclin-dependent kinase 6 1021 reviewed Kinase
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q01105 BXGT012569 Protein SET 6418 reviewed Enzyme modulator
Q01196 BXGT012575 Runt-related transcription factor 1 861 reviewed Transcription factor
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q05932 BXGT012845 Folylpolyglutamate synthase, mitochondrial 2356 reviewed Enzyme
Q06124 BXGT012856 Tyrosine-protein phosphatase non-receptor type 11 5781 reviewed
Q06187 BXGT012860 Tyrosine-protein kinase BTK 695 reviewed Kinase
Q07812 BXGT012940 Apoptosis regulator BAX 581 reviewed Signaling
Q08050 BXGT012958 Forkhead box protein M1 2305 reviewed
Q08722 BXGT013002 Leukocyte surface antigen CD47 961 reviewed
Q09472 BXGT013038 Histone acetyltransferase p300 2033 reviewed
Q10588 BXGT013202 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 683 reviewed Enzyme
Q10589 BXGT013203 Bone marrow stromal antigen 2 684 reviewed
Q12866 BXGT013273 Tyrosine-protein kinase Mer 10461 reviewed Kinase
Q13002 BXGT013303 Glutamate receptor ionotropic, kainate 2 2898 reviewed Ion channel
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13426 BXGT013353 DNA repair protein XRCC4 7518 reviewed
Q13478 BXGT013362 Interleukin-18 receptor 1 8809 reviewed Receptor
Q13535 BXGT013370 Serine/threonine-protein kinase ATR 545 reviewed Kinase
Q13547 BXGT013373 Histone deacetylase 1 3065 reviewed Epigenetic regulator
Q13641 BXGT013390 Trophoblast glycoprotein 7162 reviewed Receptor
Q13887 BXGT013401 Krueppel-like factor 5 688 reviewed Nucleic acid binding
Q14457 BXGT013472 Beclin-1 8678 reviewed Enzyme modulator
Q14790 BXGT013505 Caspase-8 841 reviewed Enzyme
Q14839 BXGT013509 Chromodomain-helicase-DNA-binding protein 4 1108 reviewed
Q14994 BXGT013519 Nuclear receptor subfamily 1 group I member 3 9970 reviewed Nuclear receptor
Q15485 BXGT013574 Ficolin-2 2220 reviewed Signaling
Q15554 BXGT013577 Telomeric repeat-binding factor 2 7014 reviewed
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q5Y7D3 BXGT015912 HLA class II histocompatibility antigen DQ beta chain 3119 unreviewed
Q6GTX8 BXGT016315 Leukocyte-associated immunoglobulin-like receptor 1 3903 reviewed Receptor
Q7L266 BXGT016993 Isoaspartyl peptidase/L-asparaginase 80150 reviewed Enzyme
Q8IWS0 BXGT018356 PHD finger protein 6 84295 reviewed Nucleic acid binding
Q92835 BXGT019382 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 3635 reviewed
Q96AZ6 BXGT019621 Interferon-stimulated gene 20 kDa protein 3669 reviewed
Q96GD4 BXGT019667 Aurora kinase B 9212 reviewed Kinase
Q96RJ3 BXGT019729 Tumor necrosis factor receptor superfamily member 13C 115650 reviewed
Q96T88 BXGT019747 E3 ubiquitin-protein ligase UHRF1 29128 reviewed
Q99538 BXGT019931 Legumain 5641 reviewed Enzyme
Q9BUQ8 BXGT020138 Probable ATP-dependent RNA helicase DDX23 9416 reviewed
Q9H4Y5 BXGT020479 Glutathione S-transferase omega-2 119391 reviewed
Q9HD26 BXGT020540 Golgi-associated PDZ and coiled-coil motif-containing protein 57120 reviewed
Q9NP58 BXGT021143 ATP-binding cassette sub-family B member 6, mitochondrial 10058 reviewed Transporter
Q9NR28 BXGT021178 Diablo homolog, mitochondrial 56616 reviewed
Q9NZ45 BXGT021269 CDGSH iron-sulfur domain-containing protein 1 55847 reviewed
Q9NZI8 BXGT021273 Insulin-like growth factor 2 mRNA-binding protein 1 10642 reviewed Enzyme
Q9P1W9 BXGT021296 Serine/threonine-protein kinase pim-2 11040 reviewed Kinase
Q9UJ41 BXGT021723 Rab5 GDP/GTP exchange factor 27342 reviewed Enzyme modulator
Q9UJU2 BXGT021730 Lymphoid enhancer-binding factor 1 51176 reviewed
Q9UKV0 BXGT021750 Histone deacetylase 9 9734 reviewed Epigenetic regulator
Q9UM47 BXGT021772 Neurogenic locus notch homolog protein 3 4854 reviewed
Q9UM73 BXGT021773 ALK tyrosine kinase receptor 238 reviewed Kinase
Q9UQF0 BXGT021812 Syncytin-1 30816 reviewed
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 373156 reviewed
Q9Y6K1 BXGT022331 DNA (cytosine-5)-methyltransferase 3A 1788 reviewed
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
P15509 BXGT022826 Granulocyte-macrophage colony-stimulating factor receptor subunit alpha 1438 reviewed Signaling
P00738 BXGT022874 Haptoglobin 3240 reviewed Enzyme
P19235 BXGT022895 Erythropoietin receptor 2057 reviewed Receptor
Q92878 BXGT023071 DNA repair protein RAD50 10111 reviewed
A9YTQ3 BXGT023537 Aryl hydrocarbon receptor repressor 57491 reviewed Transcription factor
P20138 BXGT023857 Myeloid cell surface antigen CD33 945 reviewed Receptor
Q8IX03 BXGT024000 Protein KIBRA 23286 reviewed
Q8NB49 BXGT024770 Phospholipid-transporting ATPase IG 286410 reviewed Transporter
Q7Z6A9 BXGT025024 B- and T-lymphocyte attenuator 151888 reviewed
P31358 BXGT025061 CAMPATH-1 antigen 1043 reviewed
P35251 BXGT025853 Replication factor C subunit 1 5981 reviewed
Q96SD1 BXGT025929 Protein artemis 64421 reviewed
P11836 BXGT025994 B-lymphocyte antigen CD20 931 reviewed Receptor
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease