Showing entry for Sodium/bile acid cotransporter


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013515
Protein NameSodium/bile acid cotransporter
Uniport IdQ14973
GeneSLC10A1
Gene Id6554
DomainSBF
Pfam PF01758  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.4 Digestive system hsa04976 Bile secretion
6. Human Diseases 6.9 Infectious diseases: Viral hsa05161 Hepatitis B
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0015721 bile acid and bile salt transport
Biological Process GO:0038183 bile acid signaling pathway
Biological Process GO:0035690 cellular response to drug
Biological Process GO:0120188 regulation of bile acid secretion
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:1904486 response to 17alpha-ethynylestradiol
Biological Process GO:0045471 response to ethanol
Biological Process GO:0031667 response to nutrient levels
molecular function GO:0008508 bile acid:sodium symporter activity
molecular function GO:0001618 virus receptor activity
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-159418 Recycling of bile acids and salts
R-HSA-194068 Bile acid and bile salt metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-8957322 Metabolism of steroids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001306 BXGD000037 Acute alcoholic liver disease Digestive System Diseases; Chemically-Induced Disorders; Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011226 BXGD000704 Hepatitis D Infection Digestive System Diseases; Infections
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020433 BXGD001379 Hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0022354 BXGD001540 Jaundice, Obstructive Pathological Conditions, Signs and Symptoms
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0025521 BXGD001876 Inborn Errors of Metabolism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042769 BXGD002999 Virus Diseases Infections
C0042870 BXGD003008 Vitamin D Deficiency Nutritional and Metabolic Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0238052 BXGD004866 Xanthomatosis, Cerebrotendinous Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0268318 BXGD005896 Cholestasis of pregnancy Digestive System Diseases; Female Urogenital Diseases and Pregnancy Complications
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0333980 BXGD006974 Focal Nodular Hyperplasia Digestive System Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0524909 BXGD009247 Hepatitis B, Chronic Digestive System Diseases; Infections
C0700636 BXGD009898 Focal nodular hyperplasia of liver Digestive System Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0947622 BXGD011493 Cholecystolithiasis Digestive System Diseases
C0948192 BXGD011514 Primary infection NOS
C1262535 BXGD011885 Hepatocellular jaundice Digestive System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1565886 BXGD013404 Indirect Hyperbilirubinemia, Neonatal Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1863844 BXGD016200 Adult-onset citrullinemia type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1997910 BXGD016864 Citrin deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3850141 BXGD019810 Acute-On-Chronic Liver Failure Digestive System Diseases
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4529962 BXGD023178 Fatty Liver Disease
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001325 Progesterone 314.46
BXGC0022231 Ursodiol 392.29
BXGC0037407 Lithocholic Acid 376.3
BXGC0042222 Propranolol 259.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein