Showing entry for Nuclear receptor coactivator 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013582
Protein NameNuclear receptor coactivator 2
Uniport IdQ15596
GeneNCOA2
Gene Id10499
DomainDUF1518; DUF4927; NCOA_u2; Nuc_rec_co-act; PAS; PAS_11; SRC-1
Pfam PF07469   PF16279   PF08815   PF00989   PF08832  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa04915 Estrogen signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04919 Thyroid hormone signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0015721 bile acid and bile salt transport
Biological Process GO:0032870 cellular response to hormone stimulus
Biological Process GO:1904017 cellular response to Thyroglobulin triiodothyronine
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0045475 locomotor rhythm
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0010906 regulation of glucose metabolic process
Biological Process GO:0019216 regulation of lipid metabolic process
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0032570 response to progesterone
molecular function GO:0017162 aryl hydrocarbon receptor binding
molecular function GO:0003682 chromatin binding
molecular function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
molecular function GO:0035257 nuclear hormone receptor binding
molecular function GO:0016922 nuclear receptor binding
molecular function GO:0030374 nuclear receptor transcription coactivator activity
molecular function GO:0046983 protein dimerization activity
molecular function GO:0019904 protein domain specific binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
molecular function GO:0030375 thyroid hormone receptor coactivator activity
molecular function GO:0003713 transcription coactivator activity
cellular component GO:0005737 cytoplasm
cellular component GO:0016604 nuclear body
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1368082 RORA activates gene expression
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-1592230 Mitochondrial biogenesis
R-HSA-159418 Recycling of bile acids and salts
R-HSA-162582 Signal Transduction
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-192105 Synthesis of bile acids and bile salts
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-194068 Bile acid and bile salt metabolism
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-1989781 PPARA activates gene expression
R-HSA-1989781 PPARA activates gene expression
R-HSA-211859 Biological oxidations
R-HSA-211897 Cytochrome P450 - arranged by substrate type
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-211976 Endogenous sterols
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-2990846 SUMOylation
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-3214847 HATs acetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-392499 Metabolism of proteins
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-400253 Circadian Clock
R-HSA-4839726 Chromatin organization
R-HSA-556833 Metabolism of lipids
R-HSA-556833 Metabolism of lipids
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-597592 Post-translational protein modification
R-HSA-8939211 ESR-mediated signaling
R-HSA-8957322 Metabolism of steroids
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-9018519 Estrogen-dependent gene expression
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0017411 BXGD001108 Female Genital Diseases Female Urogenital Diseases and Pregnancy Complications
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0023418 BXGD001642 leukemia Neoplasms
C0023464 BXGD001655 Acute biphenotypic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023479 BXGD001663 Acute myelomonocytic leukemia Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024523 BXGD001781 Malabsorption Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027533 BXGD001995 Neck Neoplasms Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0032962 BXGD002382 Pregnancy Complications Female Urogenital Diseases and Pregnancy Complications
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0036220 BXGD002587 Kaposi Sarcoma Neoplasms; Infections
C0039585 BXGD002821 Androgen-Insensitivity Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0156344 BXGD003851 Endometriosis of ovary Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0201850 BXGD004053 Alkaline phosphatase measurement
C0205945 BXGD004142 Sarcoma, Spindle Cell Neoplasms
C0206637 BXGD004202 Mesenchymal Chondrosarcoma Neoplasms
C0206643 BXGD004208 Neoplasms, Fibrous Tissue Neoplasms
C0206655 BXGD004218 Alveolar rhabdomyosarcoma Neoplasms
C0206656 BXGD004219 Embryonal Rhabdomyosarcoma Neoplasms
C0206731 BXGD004276 Angiofibroma Neoplasms
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0220621 BXGD004300 Childhood Acute Myeloid Leukemia Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0238339 BXGD004914 Hereditary pancreatitis Digestive System Diseases
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0268301 BXGD005890 Reifenstein Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0279612 BXGD006650 Childhood Embryonal Rhabdomyosarcoma Neoplasms
C0279613 BXGD006651 Childhood Alveolar Rhabdomyosarcoma Neoplasms
C0279627 BXGD006658 Adult Acute Myelomonocytic Leukemia Neoplasms
C0279644 BXGD006668 Childhood Acute Myelomonocytic Leukemia Neoplasms
C0334070 BXGD006986 Maturation defect
C0334342 BXGD007035 Skin appendage adenoma Neoplasms
C0334663 BXGD007149 Histiocytic sarcoma Neoplasms; Hemic and Lymphatic Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346251 BXGD007804 Sarcoma of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0429028 BXGD008646 QT interval feature (observable entity)
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0747845 BXGD010184 early pregnancy
C0876991 BXGD011323 Histiocytosis haematophagic
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1266119 BXGD011964 Solitary fibrous tumor Neoplasms
C1266134 BXGD011972 Spindle cell rhabdomyosarcoma Neoplasms; Musculoskeletal Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328504 BXGD012469 Hormone refractory prostate cancer Neoplasms; Male Urogenital Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332982 BXGD012572 Childhood Mesenchymal Chondrosarcoma Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1841972 BXGD014484 Glucocorticoid Receptor Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2239246 BXGD016968 Endometrial stromal sarcoma, high grade Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C2826025 BXGD017783 Mixed phenotype acute leukemia
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3839747 BXGD019783 Uterine tumor resembling ovarian sex cord tumor Neoplasms
C4529962 BXGD023178 Fatty Liver Disease
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4721413 BXGD023737 Juvenile angiofibroma Neoplasms; Cardiovascular Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722330 BXGD023801 Generalized Thyroid Hormone Resistance Endocrine System Diseases
C4733095 BXGD023910 HER2-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003707 Estrogen 268.36
BXGC0004275 Acetaldehyde 44.05
BXGC0005624 Genistein 270.24
BXGC0009332 Pelanin 356.5
BXGC0033960 3-Hydroxybenzo[C]Chromen-6-One 212.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein