Showing entry for Discoidin domain-containing receptor 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013678
Protein NameDiscoidin domain-containing receptor 2
Uniport IdQ16832
GeneDDR2
Gene Id4921
DomainF5_F8_type_C; Pkinase_Tyr
Pfam PF00754   PF07714  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031214 biomineral tissue development
Biological Process GO:0007155 cell adhesion
Biological Process GO:0035988 chondrocyte proliferation
Biological Process GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway
Biological Process GO:0030199 collagen fibril organization
Biological Process GO:0003416 endochondral bone growth
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0007275 multicellular organism development
Biological Process GO:0001503 ossification
Biological Process GO:0018108 peptidyl-tyrosine phosphorylation
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:0090091 positive regulation of extracellular matrix disassembly
Biological Process GO:0010763 positive regulation of fibroblast migration
Biological Process GO:0048146 positive regulation of fibroblast proliferation
Biological Process GO:0033674 positive regulation of kinase activity
Biological Process GO:0045669 positive regulation of osteoblast differentiation
Biological Process GO:0045860 positive regulation of protein kinase activity
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0030500 regulation of bone mineralization
Biological Process GO:0010715 regulation of extracellular matrix disassembly
Biological Process GO:0034103 regulation of tissue remodeling
Biological Process GO:0007165 signal transduction
Biological Process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0005518 collagen binding
molecular function GO:0038062 protein tyrosine kinase collagen receptor activity
molecular function GO:0004714 transmembrane receptor protein tyrosine kinase activity
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005925 focal adhesion
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-1474244 Extracellular matrix organization
R-HSA-3000171 Non-integrin membrane-ECM interactions
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002448 BXGD000115 Ameloblastoma Neoplasms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0013312 BXGD000814 Dupuytren Contracture Neoplasms; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0015300 BXGD000973 Exophthalmos Eye Diseases
C0016842 BXGD001083 Congenital pectus excavatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0022548 BXGD001551 Keloid Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0023827 BXGD001707 liposarcoma Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0025995 BXGD001885 Micromelia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0037926 BXGD002712 Compression of spinal cord Nervous System Diseases; Wounds and Injuries
C0039103 BXGD002791 Synovitis Musculoskeletal Diseases
C0039144 BXGD002796 Syringomyelia Nervous System Diseases
C0041956 BXGD002942 Ureteral obstruction Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0079748 BXGD003094 Precursor cell lymphoblastic lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153452 BXGD003647 Malignant neoplasm of gallbladder Digestive System Diseases; Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0158113 BXGD003875 Contracture of joint of hand Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0221354 BXGD004446 Frontal bossing Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0235989 BXGD004801 Renal interstitial fibrosis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0239399 BXGD004981 Short extremities
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0264324 BXGD005381 Calcification of trachea Nutritional and Metabolic Diseases; Respiratory Tract Diseases
C0266623 BXGD005702 Congenital anomaly of neck Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0267026 BXGD005727 Actinic cheilitis Stomatognathic Diseases
C0278608 BXGD006549 Adult Liposarcoma Neoplasms
C0278721 BXGD006572 Adult Lymphoblastic Lymphoma
C0279525 BXGD006627 Childhood Lymphoblastic Lymphoma
C0279680 BXGD006680 Transitional cell carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0279984 BXGD006703 Childhood Liposarcoma Neoplasms
C0345958 BXGD007751 Large cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0346388 BXGD007819 Malignant melanoma of choroid Neoplasms; Eye Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392476 BXGD008046 Epiphyseal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0409338 BXGD008381 Flexion contracture - elbow
C0409959 BXGD008400 Osteoarthritis, Knee Musculoskeletal Diseases
C0410653 BXGD008444 Atlantoaxial instability
C0426817 BXGD008585 Short ribs
C0432211 BXGD008737 Spondyloepimetaphyseal disorder Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0521170 BXGD009131 Osteoporotic Fractures Wounds and Injuries
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0544755 BXGD009310 Genu varum Musculoskeletal Diseases
C0549393 BXGD009374 Alcohol problem
C0557874 BXGD009444 Global developmental delay
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686377 BXGD009834 CNS metastases Neoplasms; Nervous System Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0694550 BXGD009852 Recurrent pneumonia Infections; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0751674 BXGD010547 Lymphangioleiomyomatosis Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0751688 BXGD010551 Malignant Squamous Cell Neoplasm Neoplasms
C0877165 BXGD011338 Short phalanx of finger
C0878659 BXGD011380 Disproportionate short stature Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1096285 BXGD011615 Arterial fibrosis
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1266129 BXGD011970 Atypical Lipoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1334439 BXGD012710 adenoid cystic carcinoma of lung Neoplasms
C1370889 BXGD012920 Liposarcoma, well differentiated Neoplasms
C1397139 BXGD012995 Calcification of falx cerebri
C1397307 BXGD012996 Cardiac fibrosis
C1836542 BXGD014129 Depressed nasal bridge
C1837084 BXGD014195 Short metacarpal
C1837482 BXGD014237 Thoracic hypoplasia
C1837483 BXGD014238 Posterior rib cupping
C1842229 BXGD014505 Broad metacarpals
C1844704 BXGD014665 Platyspondyly
C1846154 BXGD014788 Anterior rib cupping
C1846439 BXGD014817 Hypoplasia of the odontoid process Musculoskeletal Diseases
C1848109 BXGD014906 Long fibula
C1848446 BXGD014925 C1-C2 subluxation
C1849011 BXGD014994 SPONDYLOMETAEPIPHYSEAL DYSPLASIA, SHORT LIMB-HAND TYPE Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C1849937 BXGD015091 Disproportionate short-limb short stature
C1850135 BXGD015112 Flared metaphysis
C1853242 BXGD015322 Midface retrusion
C1854114 BXGD015383 Short nose
C1854912 BXGD015441 Short long bone
C1855185 BXGD015469 Broad phalanx
C1858085 BXGD015770 Malar flattening
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859126 BXGD015854 Stippled epiphyses
C1865186 BXGD016296 Bell-shaped thorax
C1865841 BXGD016343 Flared iliac wings
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1968577 BXGD016717 Progressive calcification of costochondral cartilage
C1968592 BXGD016718 Abnormal calcification of the carpal bones
C1969372 BXGD016775 Tubulointerstitial fibrosis
C2145472 BXGD016931 Urothelial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3149494 BXGD018281 KELOID FORMATION
C3277226 BXGD018711 Restrictive ventilatory defect
C3281200 BXGD018888 LEUKOENCEPHALOPATHY, BRAIN CALCIFICATIONS, AND CYSTS Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nutritional and Metabolic Diseases; Nervous System Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4024176 BXGD021301 Triangular shaped distal phalanges of the hand
C4024579 BXGD021328 Osteolysis involving bones of the feet Musculoskeletal Diseases
C4082169 BXGD022084 Metatarsus Varus Musculoskeletal Diseases
C4087504 BXGD022156 Peritoneal dissemination
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4721779 BXGD023769 Ovarian cancer stage IV
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0012352 Chelerythrine 348.12
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein